Overactivation of SHH signaling induces a cascade of dedifferentiation and oncogenesis in a new mouse model for choroid plexus carcinoma.
Overview
- Research Institute Children’s Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Martinistraße 52, Building N63, 20251 Hamburg, Germany
- Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
- III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
- Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
- Single Cell Core Facility, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
- Institute of Neuropathology, University Hospital Münster, Münster, Germany
- Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
- Mildred Scheel Cancer Career Centre HaTriCS4, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany
Abstract
Choroid Plexus tumors constitute 10–20% of brain tumors in infancy. Among these, Choroid Plexus Carcinomas (CPC) are highly aggressive and result in poor survival. Details on tumor initiation and oncogenic events remain largely unknown, aside from a high prevalence of TP53 mutations and marked chromosomal instability. We generated hGFAP-cre::lsl-MYCN::lsl
Supplementary Information: The online version contains supplementary material available at 10.1186/
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
The paper links to its data and to no code of its authors: see the Data section.
Tracing map
A tracing map links a paper to the code its authors published: this paper has none, so it has no map.
Data
Datasets cited
- figshare:33312697, at figshare; found in DataCite
- figshare:33312700, at figshare; found in DataCite
- figshare:33312703, at figshare; found in DataCite
- figshare:33312706, at figshare; found in DataCite
- geo:GSE289052, at NCBI GEO; found in “Data availability”
Data Availability Statement
All transcriptomic data are available under the GEO Accession number GSE289052 (https://
All transcriptomic data are available under the GEO Accession number [GSE289052 (https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 2, 28 September 2026
- Funding: added Leibniz-Gemeinschaft
Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 13 authors, 5 keywords, 13 MeSH terms, 76 references, 24 RRIDs.
Cite
This paper
Peter, L.-S., Altendorf, L., Hack, K., Thaden, V., Göbel, C., Mahnke, B., Krebs, C., Jauch-Speer, S.-L., Kordes, U. R., Obrecht-Sturm, D., Thomas, C., Schüller, U., & Schoof, M. (2026). Overactivation of SHH signaling induces a cascade of dedifferentiation and oncogenesis in a new mouse model for choroid plexus carcinoma. Acta neuropathologica communications, 14(1), 176. https://
BibTeX
@article{peter2026overac
author = {Peter, Levke-Sophie and Altendorf, Lea and Hack, Karoline and Thaden, Vanessa and Göbel, Carolin and Mahnke, Beatrix and Krebs, Christian and Jauch-Speer, Saskia-L and Kordes, Uwe R and Obrecht-Sturm, Denise and Thomas, Christian and Schüller, Ulrich and Schoof, Melanie},
title = {{Overactivation of SHH signaling induces a cascade of dedifferentiation and oncogenesis in a new mouse model for choroid plexus carcinoma}},
journal = {Acta neuropathologica communications},
year = {2026},
month = aug,
volume = {14},
number = {1},
pages = {176},
publisher = {BMC},
issn = {2051-5960},
doi = {10.1186/
url = {https://
pmid = {42629571},
pmcid = {PMC13499314}
}
RIS
TY - JOUR
AU - Peter, Levke-Sophie
AU - Altendorf, Lea
AU - Hack, Karoline
AU - Thaden, Vanessa
AU - Göbel, Carolin
AU - Mahnke, Beatrix
AU - Krebs, Christian
AU - Jauch-Speer, Saskia-L
AU - Kordes, Uwe R
AU - Obrecht-Sturm, Denise
AU - Thomas, Christian
AU - Schüller, Ulrich
AU - Schoof, Melanie
TI - Overactivation of SHH signaling induces a cascade of dedifferentiation and oncogenesis in a new mouse model for choroid plexus carcinoma
T2 - Acta neuropathologica communications
J2 - Acta Neuropathol Commun
PY - 2026
DA - 2026/
VL - 14
IS - 1
SP - 176
SN - 2051-5960
PB - BMC
DO - 10.1186/
UR - https://
LA - en
ER -
CSL-JSON
{
"id": "10.1186/
"type": "article-journal",
"title": "Overactivation of SHH signaling induces a cascade of dedifferentiation and oncogenesis in a new mouse model for choroid plexus carcinoma",
"container-title": "Acta neuropathologica communications",
"author": [
{
"family": "Peter",
"given": "Levke-Sophie"
},
{
"family": "Altendorf",
"given": "Lea"
},
{
"family": "Hack",
"given": "Karoline"
},
{
"family": "Thaden",
"given": "Vanessa"
},
{
"family": "Göbel",
"given": "Carolin"
},
{
"family": "Mahnke",
"given": "Beatrix"
},
{
"family": "Krebs",
"given": "Christian"
},
{
"family": "Jauch-Speer",
"given": "Saskia-L"
},
{
"family": "Kordes",
"given": "Uwe R"
},
{
"family": "Obrecht-Sturm",
"given": "Denise"
},
{
"family": "Thomas",
"given": "Christian"
},
{
"family": "Schüller",
"given": "Ulrich"
},
{
"family": "Schoof",
"given": "Melanie"
}
],
"container-title-short":
"volume": "14",
"issue": "1",
"page": "176",
"DOI": "10.1186/
"PMID": "42629571",
"PMCID": "PMC13499314",
"ISSN": "2051-5960",
"publisher": "BMC",
"URL": "https://
"language": "en",
"issued": {
"date-parts": [
[
2026,
8,
21
]
]
}
}
Similar papers
The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.
- [1] doi:10.1093/neuonc/noaf085
- SOX2 commands LIM homeobox transcription factors in choroid plexus development and tumorigenesis.Journal: Neuro-oncologyIn common: genetics / omics, other condition, mouse, 1 other category, 20 references, author Ulrich Schüller
- [2] doi:10.1038/s41389-023-00481-3
- The tumor suppressor CREBBP and the oncogene MYCN cooperate to induce malignant brain tumors in mice.Journal: OncogenesisIn common: other condition, mouse, cellular / molecular, 5 references, 2 authors
- [3] doi:10.1186/s40478-023-01654-2
- MYC overexpression and SMARCA4 loss cooperate to drive medulloblastoma formation in mice.Journal: Acta neuropathologica communicationsIn common: genetics / omics, other condition, mouse, 1 other category, 2 references, 2 authors
- [4] doi:10.1038/s41467-025-60442-9 [code]
- ETMR stem-like state and chemo-resistance are supported by perivascular cells at single-cell resolution.Journal: Nature communicationsIn common: genetics / omics, other condition, mouse, 1 other category, 1 reference, 2 authors
- [5] doi:10.1007/s10571-023-01361-5
- A Carboxy-terminal Smarcb1 Point Mutation Induces Hydrocephalus Formation and Affects AP-1 and Neuronal Signalling Pathways in Mice.Journal: Cellular and molecular neurobiologyIn common: genetics / omics, other condition, mouse, 1 other category, 1 reference, 2 authors
- [6] doi:10.1007/s00401-026-03050-1
- Molecular changes during AT/
RT progression associated with epithelial-mesenchymal transition and extracellular matrix changes. Journal: Acta neuropathologicaIn common: genetics / omics, other condition, 4 references, author Ulrich Schüller - [7] doi:10.1038/s43018-025-00976-5 [code]
- crossNN is an explainable framework for cross-platform DNA methylation-based classification of tumors.Journal: Nature cancerIn common: genetics / omics, other condition, 3 references, author Ulrich Schüller
- [8] doi:10.1038/s41591-024-03435-3 [code]
- Rapid brain tumor classification from sparse epigenomic data.Journal: Nature medicineIn common: genetics / omics, other condition, 3 references, author Ulrich Schüller
- [9] doi:10.1038/s41467-025-60361-9 [code]
- Sequential emergence and contraction of epithelial subtypes in the prenatal human choroid plexus revealed by a stem cell model.Journal: Nature communicationsIn common: genetics / omics, 5 references
- [10] doi:10.1007/s00401-023-02608-7
- Recurrent atypical teratoid/
rhabdoid tumors (AT/ RT) reveal discrete features of progression on histology, epigenetics, copy number profiling, and transcriptomics. Journal: Acta neuropathologicaIn common: genetics / omics, other condition, 2 references, author Ulrich Schüller
Contribute
The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.
Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.
Claim this paper
Correct its record
Say what each link of this record is, remove the ones that are not the paper's, add the ones that are missing. The correction becomes a new version of the record, in its Versions section.
Request its removal
To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).
Discussion, reproductions, activity
Discussion: code errors and mismatches between the code and the paper about this paper and its code, from readers and its authors, beside the paper and its tracing map.
Reproductions: reports from readers who ran the authors' code and did not get the paper's result, what they ran, with which environment, commit and data.
Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.