An MR-Neuroimaging Study of Structural and Vascular Brain Networks in Elderly Adults with Obesity and Diabetes who Practice Structural Yoga.
Overview
- Division of Yoga, Centre for Integrative Medicine and Research, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India
- Department of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India
- Department of Radiodiagnosis and Imaging, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India
- Department of Medical Imaging Technology, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India
Abstract
Background: Obesity and type 2 diabetes mellitus (T2DM) are associated with accelerated brain atrophy, white matter microstructural disruption, and resting-state functional network dysconnectivity in elderly adults, driven by converging vascular, neuroinflammatory, and insulin-resistance mechanisms. Yoga is a recognized mind-body intervention with documented benefits for glycaemic control, vascular health, and neurocognitive function; however, no study has yet employed multimodal MR neuroimaging to systematically characterize these brain alterations in an elderly obese-diabetic population or to evaluate yoga-induced neuroplasticity within this cohort.
Methods: This three-phase, prospective protocol will be conducted at Kasturba Hospital and the Center for Integrative Medicine and Research, Manipal Academy of Higher Education, Manipal, India. Phase 1 is a case-control study (n = 80; 40 obese-diabetic, 40 obese-non-diabetic; age 60–80 years) employing carotid Doppler ultrasonography, T1-weighted voxel-based morphometry and region-of-interest segmentation (SPM12/
Discussion: This protocol addresses a critical gap in the yoga-neuroimaging literature by providing a multimodal, multi-phase framework to characterize neurovascular disease burden and evaluate structured yoga as a neurobiologically informed lifestyle intervention in a high-risk elderly population. Findings will inform AYUSH clinical guidelines, geriatric NCD prevention programs, and future randomized controlled trials.
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data
Datasets cited
- figshare:32151694, at figshare; found in the references
Data availability
Underlying data: No data are associated with this article. This is a study protocol; no participant data have been collected at the time of publication.
Reporting guidelines: This protocol has been prepared in accordance with the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT 2025) guidelines. The completed SPIRIT 2013 checklist has been deposited in the Figshare repository.
Repository name: An MR-Neuroimaging Study of Structural and Vascular Brain Networks in Elderly Adults with Obesity and Diabetes who Practice Structural Yoga. https://
License: CC0 1.0 Universal (CC0 1.0) Public Domain Dedication (https://
Trial Registration: Clinical Trials Registry — India (CTRI): CTRI/
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 2, 28 September 2026
- Funding: added Indian Council of Medical Research: IIRPSG-2025-01-03486
Version 1, 28 September 2026: the first record
Recorded: type, language, journal, volume, pages, dates, 5 authors, 8 keywords, 14 MeSH terms, 29 references.
Cite
This paper
Paramashiva, P. S., Maiya, G. A., Kadavigere, R., Dkhar, W., & Sukumar, S. (2026). An MR-Neuroimaging Study of Structural and Vascular Brain Networks in Elderly Adults with Obesity and Diabetes who Practice Structural Yoga. F1000Research, 15, 830. https://
BibTeX
@article{paramashiva2026
author = {Paramashiva, Poovitha Shruthi and Maiya, G Arun and Kadavigere, Rajagopal and Dkhar, Winniecia and Sukumar, Suresh},
title = {{An MR-Neuroimaging Study of Structural and Vascular Brain Networks in Elderly Adults with Obesity and Diabetes who Practice Structural Yoga}},
journal = {F1000Research},
year = {2026},
month = may,
volume = {15},
pages = {830},
publisher = {Faculty of 1000 Ltd},
issn = {2046-1402},
doi = {10.12688/
url = {https://
pmid = {42344431},
pmcid = {PMC13287981}
}
RIS
TY - JOUR
AU - Paramashiva, Poovitha Shruthi
AU - Maiya, G Arun
AU - Kadavigere, Rajagopal
AU - Dkhar, Winniecia
AU - Sukumar, Suresh
TI - An MR-Neuroimaging Study of Structural and Vascular Brain Networks in Elderly Adults with Obesity and Diabetes who Practice Structural Yoga
T2 - F1000Research
J2 - F1000Res
PY - 2026
DA - 2026/
VL - 15
SP - 830
SN - 2046-1402
PB - Faculty of 1000 Ltd
DO - 10.12688/
UR - https://
LA - en
ER -
CSL-JSON
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