Assessing head injury risk and neuroprotective effect of ketone monoester supplementation in military airborne training.
Overview
- Healthspan, Resilience and Performance Research, Florida Institute for Human and Machine Cognition Pensacola Florida USA
- Bioinnovation and Genome Sciences Division Translational Genomics Research Institute Phoenix Arizona USA
- Early Detection and Prevention Division Translational Genomics Research Institute Phoenix Arizona USA
- Integrated Mass Spectrometry Shared Resource, City of Hope National Medical Center Duarte California USA
Abstract
Warfighters face significant risk of mild traumatic brain injury (mTBI) during operations and training. We performed a double‐blind, randomized, placebo‐controlled trial to: (1) determine head strike (HS) incidence, during US Army Basic Airborne Course's Improved Swing Landing Trainer (ISLT) training, (2) test protective efficacy of ketone monoester (KME) supplementation, and (3) assess blood‐based mTBI biomarker signatures. We enrolled 354 active‐duty male and female service members randomized 1:1 to placebo (PLA) or KME; n = 318 completed ISLT and assessments (PLA = 157, 142 M/
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data
Datasets cited
- figshare:31021216, at figshare; found in the text, “Multiomics”
Data availability statement
The exploratory multi‐omics methods, analysis outputs, and discussion from this study have been deposited in Figshare and are publicly available at https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 1, 30 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 20 authors, 5 keywords, 13 MeSH terms, 2 funders, 49 references.
Cite
This paper
Miyatsu, T., McAdam, J., Graham, Z. A., Mahyari, A., Mitsopoulos, K., Dorsey, A., Yeager, M., Finch, A., Alsop, E., Hutchins, E., Lovell, B., Garcia‐Mansfield, K., Meechoovet, B., Palada, J., Sharma, R., Van Keuren‐Jensen, K., Pirrotte, P., Bamman, M., Broderick, T., & Stone, M. (2026). Assessing head injury risk and neuroprotective effect of ketone monoester supplementation in military airborne training. Physiological reports, 14(6), e70818. https://
BibTeX
@article{miyatsu2026asse
author = {Miyatsu, Toshiya and McAdam, Jeremy and Graham, Zachary A. and Mahyari, Arash and Mitsopoulos, Konstantinos and Dorsey, Andrew and Yeager, Meredith and Finch, Art and Alsop, Eric and Hutchins, Elizabeth and Lovell, Brooke and Garcia‐Mansfield, Krystine and Meechoovet, Bessie and Palada, Joanna and Sharma, Ritin and Van Keuren‐Jensen, Kendall and Pirrotte, Patrick and Bamman, Marcas and Broderick, Timothy and Stone, Morley},
title = {{Assessing head injury risk and neuroprotective effect of ketone monoester supplementation in military airborne training}},
journal = {Physiological reports},
year = {2026},
month = mar,
volume = {14},
number = {6},
pages = {e70818},
publisher = {Wiley},
issn = {2051-817X},
doi = {10.14814/
url = {https://
pmid = {41852147},
pmcid = {PMC13097624}
}
RIS
TY - JOUR
AU - Miyatsu, Toshiya
AU - McAdam, Jeremy
AU - Graham, Zachary A.
AU - Mahyari, Arash
AU - Mitsopoulos, Konstantinos
AU - Dorsey, Andrew
AU - Yeager, Meredith
AU - Finch, Art
AU - Alsop, Eric
AU - Hutchins, Elizabeth
AU - Lovell, Brooke
AU - Garcia‐Mansfield, Krystine
AU - Meechoovet, Bessie
AU - Palada, Joanna
AU - Sharma, Ritin
AU - Van Keuren‐Jensen, Kendall
AU - Pirrotte, Patrick
AU - Bamman, Marcas
AU - Broderick, Timothy
AU - Stone, Morley
TI - Assessing head injury risk and neuroprotective effect of ketone monoester supplementation in military airborne training
T2 - Physiological reports
J2 - Physiol Rep
PY - 2026
DA - 2026/
VL - 14
IS - 6
SP - e70818
SN - 2051-817X
PB - Wiley
DO - 10.14814/
UR - https://
LA - en
ER -
CSL-JSON
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