Integrative analysis identifies Hspa5 as a key regulator of the ERS/UPR-immune axis in spinal cord injury.
Overview
- School of Clinical Medicine, Ningxia Medical University, Yinchuan, China
- Ningxia Key Laboratory of Stem Cell and Regenerative Medicine, Institute of Medical Sciences, General Hospital of Ningxia Medical University, Yinchuan, China
- The First Clinical College, The First Affiliated Hospital, Hainan Medical University, Haikou, China
- Department of Neurosurgery, General Hospital of Ningxia Medical University, Yinchuan, China
Abstract
Background: Endoplasmic reticulum stress (ERS) and the unfolded protein response (UPR) are critical in secondary spinal cord injury (SCI), but their systematic characterization and link to immune infiltration remain unclear. This study aimed to identify key ERS/
Methods: We analyzed bulk RNA-seq data (GSE151371) to identify differentially expressed genes (DEGs), followed by pathway enrichment analyses. Machine learning (SVM-RFE) and protein-protein interaction networks were used to screen for hub genes. The identified hub genes were validated using an independent cohort (GSE5296), single-cell sequencing data (GSE213240), and qRT-PCR in a murine SCI model.
Results: We identified 17 ERS-related and 27 UPR-related DEGs, primarily enriched in neuron death pathways. SCI samples showed elevated ERS/
Conclusion: ERS/
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
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Data
Data links
- ncbi.nlm.nih.gov/
geo , NCBI; found in “Data availability statement”
Data availability statement
Publicly available datasets were analyzed in this study. This data can be found here: The datasets (GSE151371, GSE5296, and GSE213240) used in this study are available in the GEO database (https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, pages, dates, 3 authors, 5 keywords, 55 references.
Cite
This paper
He, G., Yang, A., & Xia, H. (2026). Integrative analysis identifies Hspa5 as a key regulator of the ERS/
BibTeX
@article{he2026integrati
author = {He, Guoyuan and Yang, Aichun and Xia, Hechun},
title = {{Integrative analysis identifies Hspa5 as a key regulator of the ERS/
journal = {Frontiers in genetics},
year = {2026},
month = jun,
volume = {17},
pages = {1833119},
publisher = {Frontiers Media SA},
issn = {1664-8021},
doi = {10.3389/
url = {https://
pmid = {42394947},
pmcid = {PMC13327658}
}
RIS
TY - JOUR
AU - He, Guoyuan
AU - Yang, Aichun
AU - Xia, Hechun
TI - Integrative analysis identifies Hspa5 as a key regulator of the ERS/
T2 - Frontiers in genetics
J2 - Front Genet
PY - 2026
DA - 2026/
VL - 17
SP - 1833119
SN - 1664-8021
PB - Frontiers Media SA
DO - 10.3389/
UR - https://
LA - en
ER -
CSL-JSON
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"publisher": "Frontiers Media SA",
"URL": "https://
"language": "en",
"issued": {
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