An EEG-Based Edge-AI Framework for Alzheimer's and Creutzfeldt-Jakob Disease Classification.
The 3 matches
- [1] § 2. Materials and Methods › 2.3. Experimental Setup ↔ EEG/sourcecodes/EEG_fair_nael.py, lines 16–67 · score 0.84 · d_model, encoder layers, CNN feature extractor, Transformer encoder, ELU, max
- [2] § 2. Materials and Methods › 2.2. Proposed Hybrid EEG Decoder System › 2.2.1. Custom 1D-CNN Feature Extractor ↔ EEG/sourcecodes/EEG_fair_nael.py, lines 16–67 · score 0.72 · CNN feature extractor, Transformer encoder, Linear, ELU, max, permuted
- [3] § 2. Materials and Methods › 2.1. EEG Signal Preprocessing and Dataset Construction ↔ EEG/sourcecodes/EEG_fair_nael.py, lines 472–511 · score 0.53 · random seed, CV, CNTRL, epoch, CJD, LOSO
Paper
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The authors' code
Python · 512 lines · 17 KB · no license · 3 matches
- import os
- import json
- import csv
- import numpy as np
- from tqdm import tqdm
- from sklearn.metrics import confusion_matrix, accuracy_score, classification_report
- from sklearn.model_selection import StratifiedKFold
- import torch
- import torch.nn as nn
- from torch.utils.data import DataLoader, Dataset
- import datetime
- # Hybrid Model for NAEL Project to decode the ALzheimer's disease from CJD and CNTRL.
- class CNNTransformerEEG(nn.Module):
- def __init__(self, n_channels=19, n_times=1280, n_classes=3,
- cnn_out_channels=64, n_heads=2, n_layers=2):
- super().__init__()
- # ---- Simple CNN feature extractor (NO padding) ----
- self.cnn = nn.Sequential(
- nn.Conv1d(
- in_channels=n_channels,
- out_channels=cnn_out_channels,
- kernel_size=25,
- padding=0
- ),
- nn.BatchNorm1d(cnn_out_channels),
- nn.ELU(),
- nn.MaxPool1d(kernel_size=4),
- nn.Conv1d(
- in_channels=cnn_out_channels,
- out_channels=cnn_out_channels,
- kernel_size=15,
- padding=0
- ),
- nn.BatchNorm1d(cnn_out_channels),
- nn.ELU(),
- nn.MaxPool1d(kernel_size=4),
- )
- # ---- Transformer encoder ----
- encoder_layer = nn.TransformerEncoderLayer(
- d_model=cnn_out_channels,
- nhead=n_heads,
- batch_first=True
- )
- self.transformer = nn.TransformerEncoder(
- encoder_layer, num_layers=n_layers
- )
- # ---- Classifier ----
- self.classifier = nn.Linear(cnn_out_channels, n_classes)
- def forward(self, x):
- # x: (B, 19, 1280)
- feats = self.cnn(x) # (B, C, T')
- feats = feats.permute(0, 2, 1) # (B, T', C)
- feats = self.transformer(feats) # (B, T', C)
- pooled = feats.mean(dim=1) # (B, C)
- out = self.classifier(pooled) # (B, 3)
- return out
- ### LOAD AND CLEAN DATA AND SAVE IT TO FOLLOWING FORMAT.
- #
- # Load cleaned .npz EEG files, split into 5-second epochs.
- # CLEANED AND PROCESSED DATA SHOULD BE:
- # data_list: list of np.arrays (n_epochs, n_channels, epoch_samples)
- # labels_list: list of np.arrays (n_epochs,)
- # subject_ids: list of subject identifiers
- ### LOSO split
- def loso_split(data_list, labels_list, subject_ids):
- """
- Generator for Leave-One-Subject-Out (LOSO) splits.
- Yields (X_train, y_train, X_test, y_test, subject_id)
- """
- n_subjects = len(subject_ids)
- for i in range(n_subjects):
- X_test = data_list[i]
- y_test = labels_list[i]
- X_train = np.concatenate([data_list[j] for j in range(n_subjects) if j != i], axis=0)
- y_train = np.concatenate([labels_list[j] for j in range(n_subjects) if j != i], axis=0)
- print("subject in the training and testing", )
- yield X_train, y_train, X_test, y_test, subject_ids[i]
- def save_onnx_model(model, n_channels, n_times, filename):
- model.eval()
- dummy_input = torch.randn(1, n_channels, n_times)
- torch.onnx.export(
- model,
- dummy_input,
- filename,
- input_names=["input"],
- output_names=["output"],
- dynamic_axes={"input":{0:"batch"}, "output":{0:"batch"}},
- )
- print(f"Saved ONNX model: {filename}")
- # ------- Small dataset wrapper for DataLoader ----------
- class ADDatasetTorch(Dataset):
- """
- Torch Dataset wrapper for (n_epochs, n_channels, n_times) arrays.
- Returns (x, y) where x: float32 (n_channels, n_times)
- """
- def __init__(self, X, y):
- self.X = X.astype(np.float32)
- self.y = y.astype(np.int64)
- def __len__(self):
- return self.X.shape[0]
- def __getitem__(self, idx):
- x = self.X[idx]
- y = int(self.y[idx])
- # models can accept (B, C, T) or (B, 1, C, T) - handled by model forward
- return torch.from_numpy(x), torch.tensor(y, dtype=torch.long)
- def loso_train_and_eval(
- data_list, labels_list, subject_ids,
- make_model_fn,
- out_dir,
- batch_size,
- n_epochs,
- lr,
- weight_decay,
- device,
- k_folds_train
- ):
- import os, json, csv, time, datetime
- import numpy as np
- import torch
- import torch.nn as nn
- from torch.utils.data import DataLoader
- from sklearn.model_selection import StratifiedKFold
- from sklearn.metrics import (
- accuracy_score,
- confusion_matrix,
- classification_report,
- balanced_accuracy_score,
- precision_recall_fscore_support,
- roc_auc_score
- )
- from sklearn.preprocessing import label_binarize
- per_subject_metrics = []
- # ---------- Global aggregators ----------
- all_confusion_matrices = []
- all_subject_accs = []
- all_subject_bal_accs = []
- all_subject_f1s = []
- all_subject_prec = []
- all_subject_recall = []
- all_subject_auc = []
- all_inference_times = []
- # Create global label list for confusion matrix ordering
- label_set = sorted(list({lab for labs in labels_list for lab in labs.tolist()})) \
- if isinstance(labels_list[0], np.ndarray) else [0, 1, 2]
- labels_for_cm = label_set
- for X_train_all, y_train_all, X_test, y_test, subject_id in loso_split(
- data_list, labels_list, subject_ids):
- print("\n==========================")
- print("Held-out test subject:", subject_id)
- print("==========================")
- # ensure numpy arrays
- X_train_all = np.asarray(X_train_all)
- y_train_all = np.asarray(y_train_all)
- X_test = np.asarray(X_test)
- y_test = np.asarray(y_test)
- n_channels = X_train_all.shape[1]
- n_times = X_train_all.shape[2]
- print(f"Total training samples {len(X_train_all)} and test samples {len(X_test)}")
- # ---------- K-Fold on training set ----------
- skf = StratifiedKFold(
- n_splits=k_folds_train,
- shuffle=True,
- random_state=RANDOM_SEED
- )
- best_val_acc_overall = -np.inf
- best_model_state_overall = None
- early_stop_patience = 5
- early_stop_min_delta = 1e-4
- for fold_idx, (tr_idx, val_idx) in enumerate(
- skf.split(X_train_all, y_train_all), start=1):
- print(f"\n--- Train CV fold {fold_idx}/{k_folds_train} ---")
- X_tr, y_tr = X_train_all[tr_idx], y_train_all[tr_idx]
- X_val, y_val = X_train_all[val_idx], y_train_all[val_idx]
- train_loader = DataLoader(
- ADDatasetTorch(X_tr, y_tr),
- batch_size=batch_size,
- shuffle=True
- )
- val_loader = DataLoader(
- ADDatasetTorch(X_val, y_val),
- batch_size=batch_size,
- shuffle=False
- )
- # instantiate model fresh
- model = make_model_fn.to(device)
- opt = torch.optim.Adam(
- model.parameters(),
- lr=lr,
- weight_decay=weight_decay
- )
- criterion = nn.CrossEntropyLoss()
- best_val_acc_fold = -np.inf
- best_state_fold = None
- epochs_no_improve = 0
- for epoch in range(1, n_epochs + 1):
- # ---- Training ----
- model.train()
- for xb, yb in train_loader:
- xb, yb = xb.to(device), yb.to(device)
- opt.zero_grad()
- loss = criterion(model(xb), yb)
- loss.backward()
- opt.step()
- # ---- Validation ----
- model.eval()
- preds, gts = [], []
- with torch.no_grad():
- for xb, yb in val_loader:
- xb = xb.to(device)
- out = model(xb)
- preds.append(out.argmax(1).cpu().numpy())
- gts.append(yb.numpy())
- preds = np.concatenate(preds)
- gts = np.concatenate(gts)
- val_acc = accuracy_score(gts, preds)
- print(f"[Fold {fold_idx} | Epoch {epoch}] Val Acc: {val_acc:.4f}")
- if val_acc > best_val_acc_fold + early_stop_min_delta:
- best_val_acc_fold = val_acc
- best_state_fold = {
- k: v.cpu().clone()
- for k, v in model.state_dict().items()
- }
- epochs_no_improve = 0
- else:
- epochs_no_improve += 1
- if epochs_no_improve >= early_stop_patience:
- print(f"[Fold {fold_idx}] Early stopping triggered")
- break
- if best_val_acc_fold > best_val_acc_overall:
- best_val_acc_overall = best_val_acc_fold
- best_model_state_overall = best_state_fold
- del model, opt
- torch.cuda.empty_cache()
- # ---------- Final model for held-out subject ----------
- model_final = CNNTransformerEEG(
- n_channels=n_channels,
- n_times=n_times,
- n_classes=N_CLASSES
- ).to(device)
- if best_model_state_overall is not None:
- model_final.load_state_dict(best_model_state_overall)
- model_final.eval()
- # ---------- Save per-subject directory ----------
- subj_dir = os.path.join(out_dir, f"subject_{subject_id}")
- os.makedirs(subj_dir, exist_ok=True)
- # ---- TorchScript (for Edge-AI) ----
- script_path = os.path.join(subj_dir, f"scripted_best_model_{subject_id}.pt")
- scripted_model = torch.jit.script(model_final)
- scripted_model.save(script_path)
- print("Saved scripted model:", script_path)
- # ---- ONNX export (optional Edge runtime) ----
- try:
- dummy = torch.randn(1, n_channels, n_times).to(device)
- onnx_path = os.path.join(subj_dir, f"best_model_subject_{subject_id}.onnx")
- torch.onnx.export(
- model_final,
- dummy,
- onnx_path,
- input_names=["input"],
- output_names=["output"],
- dynamic_axes={"input": {0: "batch"}, "output": {0: "batch"}},
- opset_version=11
- )
- print("Saved ONNX model:", onnx_path)
- except Exception as e:
- print("ONNX export failed:", e)
- # ---------- Evaluate on held-out subject ----------
- test_loader = DataLoader(
- ADDatasetTorch(X_test, y_test),
- batch_size=batch_size,
- shuffle=False
- )
- preds, gts, probs_list = [], [], []
- start_time = time.time()
- with torch.no_grad():
- for xb, yb in test_loader:
- xb = xb.to(device)
- out = model_final(xb)
- prob = torch.softmax(out, dim=1).cpu().numpy() # probabilities
- pred = out.argmax(1).cpu().numpy()
- preds.append(pred)
- gts.append(yb.numpy())
- probs_list.append(prob)
- inference_time = time.time() - start_time
- preds = np.concatenate(preds)
- gts = np.concatenate(gts)
- probs = np.concatenate(probs_list)
- acc = accuracy_score(gts, preds)
- bal_acc = balanced_accuracy_score(gts, preds)
- precision, recall, f1, _ = precision_recall_fscore_support(
- gts, preds, average="macro", zero_division=0
- )
- cm = confusion_matrix(gts, preds, labels=labels_for_cm)
- avg_inf_time = inference_time / len(gts)
- # ---------- Compute per-subject ROC-AUC ----------
- y_true_bin = label_binarize(gts, classes=labels_for_cm)
- try:
- subject_auc = roc_auc_score(y_true_bin, probs, average="macro", multi_class="ovr")
- except ValueError:
- subject_auc = float("nan")
- print(f"Subject {subject_id} macro ROC-AUC: {subject_auc:.4f}")
- # ---- Save test input & labels for Edge-AI testing ----
- np.save(os.path.join(subj_dir, f"test_input_subject_{subject_id}.npy"),
- X_test.astype(np.float32))
- np.save(os.path.join(subj_dir, f"test_labels_subject_{subject_id}.npy"),
- y_test.astype(np.int64))
- # ---------- Collect metrics ----------
- per_subject_metrics.append({
- "subject_id": subject_id,
- "n_test_epochs": int(len(gts)),
- "test_acc": acc,
- "balanced_acc": bal_acc,
- "macro_f1": f1,
- "precision": precision,
- "recall": recall,
- "roc_auc": subject_auc,
- "confusion_matrix": cm.tolist(),
- "inference_time_sec": inference_time,
- "avg_time_per_epoch_sec": avg_inf_time
- })
- all_confusion_matrices.append(cm)
- all_subject_accs.append(acc)
- all_subject_bal_accs.append(bal_acc)
- all_subject_f1s.append(f1)
- all_subject_prec.append(precision)
- all_subject_recall.append(recall)
- all_subject_auc.append(subject_auc)
- all_inference_times.append(avg_inf_time)
- del model_final
- torch.cuda.empty_cache()
- # ---------- Aggregated results ----------
- agg_cm = np.sum(np.stack(all_confusion_matrices), axis=0)
- mean_acc = float(np.mean(all_subject_accs))
- std_acc = float(np.std(all_subject_accs))
- mean_prec = float(np.mean(all_subject_prec))
- std_prec = float(np.std(all_subject_prec))
- mean_recall = float(np.mean(all_subject_recall))
- std_recall = float(np.std(all_subject_recall))
- ci95 = float(1.96 * std_acc / np.sqrt(len(all_subject_accs)))
- results = {
- "per_subject": per_subject_metrics,
- "aggregate": {
- "mean_accuracy": mean_acc,
- "std_accuracy": std_acc,
- "mean_prec": mean_prec,
- "std_prec": std_prec,
- "mean_recall": mean_recall,
- "std_recall": std_recall,
- "ci95_accuracy": ci95,
- "mean_balanced_accuracy": float(np.mean(all_subject_bal_accs)),
- "mean_macro_f1": float(np.mean(all_subject_f1s)),
- "mean_macro_roc_auc": float(np.nanmean(all_subject_auc)),
- "aggregated_confusion_matrix": agg_cm.tolist(),
- "mean_inference_time_sec": float(np.mean(all_inference_times))
- }
- }
- os.makedirs(out_dir, exist_ok=True)
- timestamp = datetime.datetime.now().strftime("%Y%m%d_%H%M%S")
- # ---- Save JSON ----
- json_path = os.path.join(out_dir, f"loso_results_{timestamp}.json")
- with open(json_path, "w") as f:
- json.dump(results, f, indent=2)
- print("Saved JSON results:", json_path)
- # ---- Save CSV summary ----
- csv_path = os.path.join(out_dir, f"loso_summary_{timestamp}.csv")
- with open(csv_path, "w", newline="") as f:
- writer = csv.writer(f)
- writer.writerow([
- "subject_id",
- "n_test_epochs",
- "test_acc",
- "balanced_acc",
- "macro_f1",
- "precision",
- "recall",
- "roc_auc",
- "avg_time_per_epoch_sec"
- ])
- for r in per_subject_metrics:
- writer.writerow([
- r["subject_id"],
- r["n_test_epochs"],
- r["test_acc"],
- r["balanced_acc"],
- r["macro_f1"],
- r["precision"],
- r["recall"],
- r["roc_auc"],
- r["avg_time_per_epoch_sec"]
- ])
- print("Saved CSV summary:", csv_path)
- return per_subject_metrics
- # ---------- To Run the models ----------
- if __name__ == "__main__":
- ROOT_DIR = "/home/.../EEG_AD_CUT/working/cleaned_filtered/" # folder with AD/, CJD/, CNTRL/ subfolders containing .npz
- MODEL_NAME = "hybrid"
- OUT_DIR = "hybrid_loso_results"
- BATCH_SIZE = 64
- LR = 1e-3
- WEIGHT_DECAY = 1e-4
- N_EPOCHS = 30
- K_FOLDS_TRAIN = 5 # k-fold CV on training set to choose best fold model
- DEVICE = torch.device("cuda" if torch.cuda.is_available() else "cpu")
- SFREQ = 256
- EPOCH_LEN_S = 5
- N_CLASSES = 3 # AD, CJD, CNTRL
- RANDOM_SEED = 2025
- # -----------------------------------
- np.random.seed(RANDOM_SEED)
- torch.manual_seed(RANDOM_SEED)
- os.makedirs(OUT_DIR, exist_ok=True)
- # load data using your provided loader
- #data_list, labels_list, subject_ids = YOUR DATA CLEANING FUNCTION TO CALL
- # Sanity check
- print("Loaded subjects:", subject_ids)
- print([d.shape for d in data_list])
- # CNN + DNN WITH TRANSFORMEER
- model = CNNTransformerEEG(n_channels=19, n_times=1280, n_classes=3) # CALL PROPOSED HYBRID MODEL
- # tHIS WILL CREATE AND SAVE THE LOSO RESULTS AT YOUR CREATED DIRECTORY
- results = loso_train_and_eval(data_list, labels_list, subject_ids, model,
- out_dir=OUT_DIR, batch_size=BATCH_SIZE, n_epochs=N_EPOCHS,
- lr=LR, weight_decay=WEIGHT_DECAY, device=DEVICE, k_folds_train=K_FOLDS_TRAIN)
- print("LOSO finished. Summary per-subject saved to disk.")
EEG_fair_nael.py at commit 4d0647a, no license · at the source
Overview
- DICEAM, Mediterranea University of Reggio Calabria, 89125 Reggio Calabria, Italy; (N.M.); (F.C.M.)
- DICMaPI, University of Naples “Federico II”, 80125 Naples, Italy
- Department of Medical and Surgical Sciences, Magna Græcia University of Catanzaro, 88100 Catanazaro, Italy; (A.P.); (E.F.)
- Regional Epilepsy Centre, Great Metropolitan “Bianchi-Melacrino-Morelli” Hospital, 89124 Reggio Calabria, Italy
Abstract
Electroencephalography (EEG) has emerged as a promising non-invasive tool for the diagnosis of neurodegenerative disorders, and artificial intelligence (AI) has shown significant potential in this domain, as demonstrated by recent studies. However, strong inter-subject variability remains a major challenge, limiting the ability of AI-based models to learn disease-specific features that generalize across individuals, thereby hindering the development of clinically deployable subject-independent systems. In this work, we propose a cross-subject, AI-based EEG classification framework to distinguish between Alzheimer’s disease (AD), Creutzfeldt–Jakob disease (CJD), and healthy control subjects using clinical EEG data collected from a local hospital. A lightweight hybrid deep learning model is developed, combining a two-layer one-dimensional convolutional neural network with a two-layer Transformer encoder to capture both local temporal patterns and long-range dependencies in EEG signals. The proposed model achieves an average classification accuracy of 97%, representing a 3% improvement over a baseline model evaluated on a cohort of 36 subjects. To assess deployment feasibility in real-time clinical settings, the trained model is implemented and evaluated on an edge-AI platform (NVIDIA Jetson AGX Orin), demonstrating energy efficiency for the inference with a compact model footprint. These results indicate that the proposed approach provides an accurate, efficient, and practically deployable solution for subject-independent EEG-based classification of neurological disorders.
Reproduced under the paper's license (CC BY), from the paper cited above.
Repository
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ai-lab-unirc/fair-nael-database
4d0647a7ab6317d58c318a932924bfdeeada9fec, 31 March 2026Availability: 1 check, the latest on 27 September 2026: the link answers
- 27 September 2026: the link answers
4 files
- EEG/
sourcecodes/ , Python, 512 lines, 3 matchesEEG_fair_nael.py - TAC/
sourcecodes/ , Python, 124 linesraw_to_dicom.py - TAC/
sourcecodes/ , Python, 66 linesraw_to_nifti.py - README.md, Text, 88 lines
The paper's code and data availability statement is in the Data section.
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Data Availability Statement
The analyzed dataset is available at the following link: https://
Reproduced under the paper's license (CC BY), from the paper cited above.
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Version 1, 28 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 6 authors, 8 keywords, 11 MeSH terms, 6 funders, 19 references.
Cite
This paper
Suffian, M., Ieracitano, C., Mammone, N., Pascarella, A., Ferlazzo, E., & Morabito, F. C. (2026). An EEG-Based Edge-AI Framework for Alzheimer's and Creutzfeldt-Jakob Disease Classification. Sensors (Basel, Switzerland), 26(10), 3274. https://
BibTeX
@article{suffian2026eeg,
author = {Suffian, Muhammad and Ieracitano, Cosimo and Mammone, Nadia and Pascarella, Angelo and Ferlazzo, Edoardo and Morabito, Francesco Carlo},
title = {{An EEG-Based Edge-AI Framework for Alzheimer's and Creutzfeldt-Jakob Disease Classification}},
journal = {Sensors (Basel, Switzerland)},
year = {2026},
month = may,
volume = {26},
number = {10},
pages = {3274},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
issn = {1424-8220},
doi = {10.3390/
url = {https://
pmid = {42198082},
pmcid = {PMC13211057}
}
RIS
TY - JOUR
AU - Suffian, Muhammad
AU - Ieracitano, Cosimo
AU - Mammone, Nadia
AU - Pascarella, Angelo
AU - Ferlazzo, Edoardo
AU - Morabito, Francesco Carlo
TI - An EEG-Based Edge-AI Framework for Alzheimer's and Creutzfeldt-Jakob Disease Classification
T2 - Sensors (Basel, Switzerland)
J2 - Sensors (Basel)
PY - 2026
DA - 2026/
VL - 26
IS - 10
SP - 3274
SN - 1424-8220
PB - Multidisciplinary Digital Publishing Institute (MDPI)
DO - 10.3390/
UR - https://
LA - en
ER -
CSL-JSON
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