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Effect of MALT1 inhibition by MI‑2 on the microglial phenotype switch, inflammatory cytokine secretion, neuronal loss and oxidative stress in Alzheimer's disease.

Overview

Authors: Yuanlong Li1,2,3, Hua Fan4, Xiong Han5, Ming Ni6, Xiaodan Hou7, Hailan Xia8, Yinzhu Shi8, Lin Zhang8, Jun Sun1,2,3
  1. Department of Pharmacy, Henan Provincial People's Hospital, Zhengzhou, Henan 450003, P.R. China
  2. Department of Pharmacy, People's Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan 450053, P.R. China
  3. Department of Pharmacy, People's Hospital of Henan University, School of Clinical Medicine, Henan University, Zhengzhou, Henan 450003, P.R. China
  4. School of Clinical Medicine, The First Affiliated Hospital of Henan University of Science and Technology, Henan University of Science and Technology, Luoyang, Henan 471003, P.R. China
  5. Department of Neurology, Henan Provincial People's Hospital, Zhengzhou, Henan 450003, P.R. China
  6. Department of Clinical Pharmacy, Fuwai Central China Cardiovascular Hospital, Zhengzhou, Henan 450053, P.R. China
  7. Ward of Heart Failure, Fuwai Central China Cardiovascular Hospital, Zhengzhou, Henan 450000, P.R. China
  8. Department of Pharmacy, Henan Province Reproductive Maternity Hospital, Zhengzhou, Henan 450000, P.R. China
Journal: International journal of molecular medicine, volume 58, issue 5, article 302
Dates: received 6 January 2026; accepted 15 July 2026; published online 31 August 2026; in print November 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.3892/ijmm.2026.5973 · PMID 42695408 · PMCID PMC13553038 · OpenAlex W7204758827
Open access: hybrid, a free copy (OpenAlex)
Status: data only
Categories: human (organism), mouse (organism), Alzheimer's / dementia (population), cellular / molecular (subfield)
Methods: Statistics
Keywords: Alzheimer's disease, MALT1 inhibition, NF-κB, microglial phenotype, inflammation, neuronal loss
MeSH: Alzheimer Disease*, Cytokines*, Microglia*, Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein*, Neurons*, Oxidative Stress*, Amyloid beta-Peptides, Animals, Cell Line, Cell Survival, Humans, Mice, NF-kappa B, Phenotype, Reactive Oxygen Species (* major topic)
Topic: Neuroinflammation and Neurodegeneration Mechanisms (Neurology, Neuroscience), according to OpenAlex
Citations: not cited yet (Europe PMC); 62 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Tracing map

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Data

Datasets cited

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • no repository, dataset or request procedure was recognized in it

Read it in the paper: doi.org/10.3892/ijmm.2026.5973.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 3, 28 September 2026

  • Funding: added Henan Provincial People's Hospital: 23456

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 9 authors, 6 keywords, 15 MeSH terms, 62 references.

Cite

This paper

Li, Y., Fan, H., Han, X., Ni, M., Hou, X., Xia, H., Shi, Y., Zhang, L., & Sun, J. (2026). Effect of MALT1 inhibition by MI‑2 on the microglial phenotype switch, inflammatory cytokine secretion, neuronal loss and oxidative stress in Alzheimer's disease. International journal of molecular medicine, 58(5), 302. https://doi.org/10.3892/ijmm.2026.5973

BibTeX

@article{li2026effect,
author = {Li, Yuanlong and Fan, Hua and Han, Xiong and Ni, Ming and Hou, Xiaodan and Xia, Hailan and Shi, Yinzhu and Zhang, Lin and Sun, Jun},
title = {{Effect of MALT1 inhibition by MI‑2 on the microglial phenotype switch, inflammatory cytokine secretion, neuronal loss and oxidative stress in Alzheimer's disease}},
journal = {International journal of molecular medicine},
year = {2026},
month = sep,
volume = {58},
number = {5},
pages = {302},
publisher = {Spandidos Publications},
issn = {1107-3756},
doi = {10.3892/ijmm.2026.5973},
url = {https://doi.org/10.3892/ijmm.2026.5973},
pmid = {42695408},
pmcid = {PMC13553038}
}

RIS

TY - JOUR
AU - Li, Yuanlong
AU - Fan, Hua
AU - Han, Xiong
AU - Ni, Ming
AU - Hou, Xiaodan
AU - Xia, Hailan
AU - Shi, Yinzhu
AU - Zhang, Lin
AU - Sun, Jun
TI - Effect of MALT1 inhibition by MI‑2 on the microglial phenotype switch, inflammatory cytokine secretion, neuronal loss and oxidative stress in Alzheimer's disease
T2 - International journal of molecular medicine
J2 - Int J Mol Med
PY - 2026
DA - 2026/09/04
VL - 58
IS - 5
SP - 302
SN - 1107-3756
PB - Spandidos Publications
DO - 10.3892/ijmm.2026.5973
UR - https://doi.org/10.3892/ijmm.2026.5973
LA - en
ER -

CSL-JSON

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"container-title": "International journal of molecular medicine",
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"PMID": "42695408",
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"ISSN": "1107-3756",
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"language": "en",
"issued": {
"date-parts": [
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}

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