Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain.
Overview
- Department of Anesthesia, McGill University, Montreal, Canada
- Faculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, Canada
- Alan Edwards Centre for Research on Pain, McGill University, Montreal, Canada
- Department of Biochemistry and Goodman Cancer Research Centre, McGill University, Montreal, Canada
- Département de biomédecine vétérinaire, Faculté de médecine vétérinaire, Université de Montréal, Montreal, Canada
- Centre de recherche sur le cerveau et l’apprentissage (CIRCA), Université de Montréal, Montréal, Canada
- Patrick G. Johnston Centre for Cancer Research, Queen's University Belfast, Belfast, United Kingdom
- Department of Neuroscience and Center for Advanced Pain Studies, University of Texas at Dallas, Dallas, United States
- Ionis Pharmaceuticals, Inc, Carlsbad, United States
- Biomedical Research Institute, Foundation for Research and Technology-Hellas, University Campus, Ioannina, Greece
- Department of Psychology, Faculty of Science, McGill University, Montreal, Canada
Abstract
Sensitization of spinal nociceptive circuits plays a crucial role in neuropathic pain. This sensitization depends on new gene expression that is primarily regulated via transcriptional and translational control mechanisms. The relative roles of these mechanisms in regulating gene expression in the clinically relevant chronic phase of neuropathic pain are not well understood. Here, we show that, in mice, changes in gene expression in the spinal cord during the chronic phase of neuropathic pain are substantially regulated at the translational level. Downregulating spinal translation at the chronic phase alleviated pain hypersensitivity. Cell type-specific profiling revealed that spinal inhibitory and excitatory neurons exhibited substantial changes in translation after peripheral nerve injury. Notably, increasing translation selectively in all inhibitory neurons or parvalbumin-positive (PV+) interneurons, but not excitatory neurons, promoted mechanical pain hypersensitivity. Furthermore, increasing translation in PV+ neurons decreased their intrinsic excitability and spiking activity. Conversely, reducing translation in spinal PV+ neurons prevented the nerve injury-induced decrease in excitability but did not alleviate mechanical hypersensitivity. Together, these findings advance our understanding of translational control mechanisms in the spinal cord during neuropathic pain and highlight their cell type- and phase-specific contributions to gene expression and pain hypersensitivity.
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
The paper links to its data, not to its authors' code: see the Data section.
Tracing map
A tracing map links a paper to the code its authors published: this paper has none, so it has no map.
Data
Datasets cited
- geo:GSE265957 — at NCBI GEO; found in “Data availability”
Data availability
Sequencing data generated in this study have been deposited in the Gene Expression Omnibus under the accession GSE265957 (https://
The following dataset was generated:
Lister KC, Wong C, Uttam S, Parisien M. 2024. Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain. NCBI Gene Expression Omnibus. GSE265957
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 1, 29 September 2026: the first record
Recorded: type, language, journal, volume, pages, dates, 25 authors, 1 keyword, 9 MeSH terms, 4 funders, 76 references, 2 RRIDs.
Cite
This paper
Lister, K. C., Wong, C., Uttam, S., Parisien, M., Stecum, P., Brown, N., Cai, W., Ho-Tieng, D., Hooshmandi, M., Gu, N., Amiri, M., Beaudry, F., Jafarnejad, S. M., Tavares-Ferreira, D., Inturi, N. N., Mazhar, K., Zhao, H. T., Fitzsimmons, B., Gkogkas, C. G., . . . Khoutorsky, A. (2026). Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain. eLife, 13, RP100451. https://
BibTeX
@article{lister2026trans
author = {Lister, Kevin C and Wong, Calvin and Uttam, Sonali and Parisien, Marc and Stecum, Patricia and Brown, Nicole and Cai, Weihua and Ho-Tieng, David and Hooshmandi, Mehdi and Gu, Ning and Amiri, Mehdi and Beaudry, Francis and Jafarnejad, Seyed Mehdi and Tavares-Ferreira, Diana and Inturi, Nikhil Nageshwar and Mazhar, Khadijah and Zhao, Hien T and Fitzsimmons, Bethany and Gkogkas, Christos G and Sonenberg, Nahum and Price, Theodore J and Diatchenko, Luda and Atlasi, Yaser and Mogil, Jeffrey S and Khoutorsky, Arkady},
title = {{Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain}},
journal = {eLife},
year = {2026},
month = apr,
volume = {13},
pages = {RP100451},
publisher = {eLife Sciences Publications, Ltd},
issn = {2050-084X},
doi = {10.7554/
url = {https://
pmid = {41960785},
pmcid = {PMC13068433}
}
RIS
TY - JOUR
AU - Lister, Kevin C
AU - Wong, Calvin
AU - Uttam, Sonali
AU - Parisien, Marc
AU - Stecum, Patricia
AU - Brown, Nicole
AU - Cai, Weihua
AU - Ho-Tieng, David
AU - Hooshmandi, Mehdi
AU - Gu, Ning
AU - Amiri, Mehdi
AU - Beaudry, Francis
AU - Jafarnejad, Seyed Mehdi
AU - Tavares-Ferreira, Diana
AU - Inturi, Nikhil Nageshwar
AU - Mazhar, Khadijah
AU - Zhao, Hien T
AU - Fitzsimmons, Bethany
AU - Gkogkas, Christos G
AU - Sonenberg, Nahum
AU - Price, Theodore J
AU - Diatchenko, Luda
AU - Atlasi, Yaser
AU - Mogil, Jeffrey S
AU - Khoutorsky, Arkady
TI - Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain
T2 - eLife
J2 - eLife
PY - 2026
DA - 2026/
VL - 13
SP - RP100451
SN - 2050-084X
PB - eLife Sciences Publications, Ltd
DO - 10.7554/
UR - https://
LA - en
ER -
CSL-JSON
{
"id": "10.7554/
"type": "article-journal",
"title": "Translational control in the spinal cord regulates gene expression and pain hypersensitivity in the chronic phase of neuropathic pain",
"container-title": "eLife",
"author": [
{
"family": "Lister",
"given": "Kevin C"
},
{
"family": "Wong",
"given": "Calvin"
},
{
"family": "Uttam",
"given": "Sonali"
},
{
"family": "Parisien",
"given": "Marc"
},
{
"family": "Stecum",
"given": "Patricia"
},
{
"family": "Brown",
"given": "Nicole"
},
{
"family": "Cai",
"given": "Weihua"
},
{
"family": "Ho-Tieng",
"given": "David"
},
{
"family": "Hooshmandi",
"given": "Mehdi"
},
{
"family": "Gu",
"given": "Ning"
},
{
"family": "Amiri",
"given": "Mehdi"
},
{
"family": "Beaudry",
"given": "Francis"
},
{
"family": "Jafarnejad",
"given": "Seyed Mehdi"
},
{
"family": "Tavares-Ferreira",
"given": "Diana"
},
{
"family": "Inturi",
"given": "Nikhil Nageshwar"
},
{
"family": "Mazhar",
"given": "Khadijah"
},
{
"family": "Zhao",
"given": "Hien T"
},
{
"family": "Fitzsimmons",
"given": "Bethany"
},
{
"family": "Gkogkas",
"given": "Christos G"
},
{
"family": "Sonenberg",
"given": "Nahum"
},
{
"family": "Price",
"given": "Theodore J"
},
{
"family": "Diatchenko",
"given": "Luda"
},
{
"family": "Atlasi",
"given": "Yaser"
},
{
"family": "Mogil",
"given": "Jeffrey S"
},
{
"family": "Khoutorsky",
"given": "Arkady"
}
],
"container-title-short":
"volume": "13",
"page": "RP100451",
"DOI": "10.7554/
"PMID": "41960785",
"PMCID": "PMC13068433",
"ISSN": "2050-084X",
"publisher": "eLife Sciences Publications, Ltd",
"URL": "https://
"language": "en",
"issued": {
"date-parts": [
[
2026,
4,
10
]
]
}
}
Similar papers
The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.
- [1] doi:10.1016/j.crmeth.2026.101412
- An improved preservation method for human dorsal root ganglion neurons enables wider access to human molecular pain neuroscience.Journal: Cell reports methodsIn common: pain, cellular / molecular, 1 reference, author Theodore J. Price
- [2] doi:10.1038/s41586-026-10296-y [code]
- Deconstruction of a spino-brain-spinal cord circuit that drives chronic pain.Journal: NatureIn common: pain, mouse, 3 references
- [3] doi:10.1038/s41467-026-73518-x [code]
- Scg2 drives corticospinal circuit reorganization with spinal premotor interneurons and astrocytes for motor recovery after stroke in mice.Journal: Nature communicationsIn common: mouse, 4 references
- [4] doi:10.1038/s41467-026-74968-z [code]
- Activity-dependent ribosome profiling reveals the landscape of canonical and non-canonical translation in brain tissue.Journal: Nature communicationsIn common: mouse, cellular / molecular, 3 references
- [5] doi:10.1172/jci197345
- Catecholamine-mediated release of miR-133a-3p from adipocytes regulates the onset of chronic primary pain.Journal: The Journal of clinical investigationIn common: pain, mouse, cellular / molecular, 2 references
- [6] doi:10.1002/cns.70872
- The Small Molecule Compound Eupalinolide B Ameliorates Depressive Behaviors and Neuropathic Pain in Mice With Spared Nerve Injury: Integrating Network Pharmacology, Molecular Docking, Bioinformatics, Molecular Dynamics Simulation and Experimental Verification.Journal: CNS neuroscience & therapeuticsIn common: pain, mouse, cellular / molecular, 2 references
- [7] doi:10.1038/s41467-026-71289-z
- Descending inhibitory rostral ventromedial medulla neurons cause widespread antinociception and contribute to the pain-inhibits-pain phenomenon.Journal: Nature communicationsIn common: pain, mouse, 2 references
- [8] doi:10.2147/jpr.s566042
- Quantum Mechanical Mechanisms in the Therapeutic Effects of Spinal Cord Stimulation to Treat Chronic Neuropathic Pain: A Quantum Computational Model.Journal: Journal of pain researchIn common: pain, cellular / molecular, 2 references
- [9] doi:10.1016/j.xcrm.2026.102800 [code]
- Recombinant dimeric PICK1 peptide inhibitors for long-term relief of chronic pain by AAV therapeutics.Journal: Cell reports. MedicineIn common: pain, mouse, 2 references
- [10] doi:10.1186/s10194-026-02399-8
- Early life stress induces brain-wide electrical network predisposition to migraine.Journal: The journal of headache and painIn common: pain, mouse, 2 references
Contribute
The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.
Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.
Claim this paper
Correct its record
Say what each link of this record is, remove the ones that are not the paper's, add the ones that are missing. The correction becomes a new version of the record, in its Versions section.
Request its removal
To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).
Discussion, reproductions, activity
Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.
Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.
Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.