Risk factors underlying brain structure change rate in cognitive decline: Results from genomewide and phenomewide investigations.
Overview
- Department of Biological Sciences Purdue University West Lafayette Indiana USA
- Computer Science, Purdue University West Lafayette Indiana USA
Abstract
INTRODUCTION: The genetic and clinical factors influencing the rate of brain structure change in cognitive decline remain poorly understood. This study aimed to identify genetic variants and risk factors contributing to these changes and explore potential causal relationships.
METHODS: We analyzed data from 2036 individuals across three longitudinal cohorts to assess change rates in 17 brain regions associated with cognitive decline. Genome‐wide association studies (GWASs) were followed by phenome‐wide association studies (PheWASs), Mendelian randomization (MR), and independent replication.
RESULTS: We identified loci associated with brain structure change, including known Alzheimer's disease genes (apolipoprotein E, APOC1) and novel signals (BEAN1, SDHC). PheWAS and MR analyses in large biobanks suggested potential causal links between brain atrophy and anemia‐related traits as well as type 2 diabetes.
DISCUSSION: Our findings highlight genetic contributors and clinical traits associated with brain structure change in cognitive decline. Larger studies with broader cognitive assessments are needed to validate these findings.
Reproduced under the paper's license (CC BY-NC), from the paper cited above.
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Data
Datasets cited
- synapse.org/
synapse:syn22252881 — at Synapse; found in “DATA AVAILABILITY STATEMENT”
Data availability statement
The ADGC cohort data are accessible through NIAGADS (https://
Reproduced under the paper's license (CC BY-NC), from the paper cited above.
Versions
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Version 1, 28 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 4 authors, 6 keywords, 17 MeSH terms, 1 funder, 75 references.
Cite
This paper
Jin, Y., Topaloudi, A., Drineas, P., & Paschou, P. (2026). Risk factors underlying brain structure change rate in cognitive decline: Results from genomewide and phenomewide investigations. Alzheimer's & dementia : the journal of the Alzheimer's Association, 22(4), e71411. https://
BibTeX
@article{jin2026risk,
author = {Jin, Yin and Topaloudi, Apostolia and Drineas, Petros and Paschou, Peristera},
title = {{Risk factors underlying brain structure change rate in cognitive decline: Results from genomewide and phenomewide investigations}},
journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
year = {2026},
month = apr,
volume = {22},
number = {4},
pages = {e71411},
publisher = {Wiley},
issn = {1552-5260},
doi = {10.1002/
url = {https://
pmid = {42010774},
pmcid = {PMC13095869}
}
RIS
TY - JOUR
AU - Jin, Yin
AU - Topaloudi, Apostolia
AU - Drineas, Petros
AU - Paschou, Peristera
TI - Risk factors underlying brain structure change rate in cognitive decline: Results from genomewide and phenomewide investigations
T2 - Alzheimer's & dementia : the journal of the Alzheimer's Association
J2 - Alzheimers Dement
PY - 2026
DA - 2026/
VL - 22
IS - 4
SP - e71411
SN - 1552-5260
PB - Wiley
DO - 10.1002/
UR - https://
LA - en
ER -
CSL-JSON
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