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Genetic correlation analysis of Alzheimer's disease and stroke implicates PHLPP1 as a shared locus in individuals of African ancestry.

Overview

Authors: Nicholas R Ray1, Jiji Kurup1, Ajneesh Kumar1, Farid Rajabli2, Liyong Wang2, Wanying Xu3, Fulai Jin3, Elanur Yilmaz1, Caghan Kizil1, Luciana Bertholim‐Nasciben2, Sofia Moura2, Aura M Ramirez2, Olusegun Baiyewu4, Anthony J Griswold2, Motunrayo Coker4, Kyle M Scott2, Kazeem Akinwande4, Larry D Adams2, Samuel Diala4, Patrice G Whitehead2
and 33 other authorsJacob L McCauley2, Mayowa Ogunronbi4, Kara L Hamilton‐Nelson2, Albertino Damasceno5, Andrew F Zaman2, Susan H Blanton2, Albert Akpalu6, Michael L Cuccaro2, Kolawole Wahab7, Katalina F McInerney2, Karen Nuytemans2, Reginald Obiako8, Pedro R Mena2, Njideka Okubadejo9, Izri M Martinez2, Yared Z Zewde10, Seid A Gugssa10, Fred S Sarfo11, Raj Kalaria12, David M Ndetei13, Scott M Williams3, Allison Caban‐Holt14, ADGC, AfDC, Giuseppe Tosto1, Jonathan L Haines3, Rufus O Akinyemi4, Adesola Ogunniyi4, Goldie S Byrd14, William S Bush3, Brian W Kunkle2, Jeffery M Vance2, Margaret A Pericak‐Vance2, Christiane Reitz1
14 affiliations
  1. Columbia University Irving Medical Center, New York, New York, USA
  2. University of Miami Miller School of Medicine, Miami, Florida, USA
  3. Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
  4. College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria
  5. Faculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique
  6. University of Ghana Medical School, Accra, Ghana
  7. Department of Medicine, University of Ilorin, Ilorin, Nigeria
  8. Ahmadu Bello University, Zaria, Kaduna, Nigeria
  9. College of Medicine, University of Lagos, Lagos, Nigeria
  10. College of Health Sciences of Addis Ababa University, Addis Ababa, Addis Ababa, Ethiopia
  11. Komfo Anokye Teaching Hospital, Kumasi, Ghana
  12. Institute for Ageing and Health, Newcastle University, Newcastle, UK
  13. Africa Institute of Mental and Brain Health, University of Nairobi, Nairobi, Kenya
  14. Wake Forest University School of Medicine, Winston‐Salem, North Carolina, USA
Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association, volume 22, issue 4, article e71433
Dates: received 5 December 2025; accepted 27 February 2026; published online 27 April 2026; in print April 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1002/alz.71433 · PMID 42043782 · PMCID PMC13116102 · OpenAlex W7156210996
Open access: hybrid, a free copy (OpenAlex)
Status: data only
Categories: genetics / omics (modality), human (organism), Alzheimer's / dementia (population), stroke (population), cellular / molecular (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions
Keywords: Alzheimer's disease, genetic covariance, stroke
MeSH: Alzheimer Disease*, Black People*, Nuclear Proteins*, Phosphoprotein Phosphatases*, Stroke*, African People, Aged, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Male, Polymorphism, Single Nucleotide (* major topic)
Topic: Genetic Associations and Epidemiology (Genetics, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: National Institute on Aging (AG057659, AG072959, U01AG084545, U01AG052410, U01AG072579, AG058654, U19AG074865, R01AG072547, RF1AG059018); NIA NIH HHS (AG058654, AG072959, U01 AG052410, P30 AG072959, R01AG072547, U01 AG057659, U01AG072579, U01AG084545, AG057659, RF1 AG059018, RF1AG059018, U01 AG072579, R01 AG072547, U01 AG079850, U01 AG058654, U19AG074865, U24 AG056270, U01 AG084545, U01AG052410, U19 AG074865)
Citations: not cited yet (Europe PMC); 71 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Versions

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Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 53 authors, 3 keywords, 13 MeSH terms, 2 funders, 65 references.

Cite

This paper

Ray, N. R., Kurup, J., Kumar, A., Rajabli, F., Wang, L., Xu, W., Jin, F., Yilmaz, E., Kizil, C., Bertholim‐Nasciben, L., Moura, S., Ramirez, A. M., Baiyewu, O., Griswold, A. J., Coker, M., Scott, K. M., Akinwande, K., Adams, L. D., Diala, S., . . . Reitz, C. (2026). Genetic correlation analysis of Alzheimer's disease and stroke implicates PHLPP1 as a shared locus in individuals of African ancestry. Alzheimer's & dementia : the journal of the Alzheimer's Association, 22(4), e71433. https://doi.org/10.1002/alz.71433

BibTeX

@article{ray2026genetic,
author = {Ray, Nicholas R and Kurup, Jiji and Kumar, Ajneesh and Rajabli, Farid and Wang, Liyong and Xu, Wanying and Jin, Fulai and Yilmaz, Elanur and Kizil, Caghan and Bertholim‐Nasciben, Luciana and Moura, Sofia and Ramirez, Aura M and Baiyewu, Olusegun and Griswold, Anthony J and Coker, Motunrayo and Scott, Kyle M and Akinwande, Kazeem and Adams, Larry D and Diala, Samuel and Whitehead, Patrice G and McCauley, Jacob L and Ogunronbi, Mayowa and Hamilton‐Nelson, Kara L and Damasceno, Albertino and Zaman, Andrew F and Blanton, Susan H and Akpalu, Albert and Cuccaro, Michael L and Wahab, Kolawole and McInerney, Katalina F and Nuytemans, Karen and Obiako, Reginald and Mena, Pedro R and Okubadejo, Njideka and Martinez, Izri M and Zewde, Yared Z and Gugssa, Seid A and Sarfo, Fred S and Kalaria, Raj and Ndetei, David M and Williams, Scott M and Caban‐Holt, Allison and {ADGC, AfDC} and Tosto, Giuseppe and Haines, Jonathan L and Akinyemi, Rufus O and Ogunniyi, Adesola and Byrd, Goldie S and Bush, William S and Kunkle, Brian W and Vance, Jeffery M and Pericak‐Vance, Margaret A and Reitz, Christiane},
title = {{Genetic correlation analysis of Alzheimer's disease and stroke implicates PHLPP1 as a shared locus in individuals of African ancestry}},
journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
year = {2026},
month = apr,
volume = {22},
number = {4},
pages = {e71433},
publisher = {Wiley},
issn = {1552-5260},
doi = {10.1002/alz.71433},
url = {https://doi.org/10.1002/alz.71433},
pmid = {42043782},
pmcid = {PMC13116102}
}

RIS

TY - JOUR
AU - Ray, Nicholas R
AU - Kurup, Jiji
AU - Kumar, Ajneesh
AU - Rajabli, Farid
AU - Wang, Liyong
AU - Xu, Wanying
AU - Jin, Fulai
AU - Yilmaz, Elanur
AU - Kizil, Caghan
AU - Bertholim‐Nasciben, Luciana
AU - Moura, Sofia
AU - Ramirez, Aura M
AU - Baiyewu, Olusegun
AU - Griswold, Anthony J
AU - Coker, Motunrayo
AU - Scott, Kyle M
AU - Akinwande, Kazeem
AU - Adams, Larry D
AU - Diala, Samuel
AU - Whitehead, Patrice G
AU - McCauley, Jacob L
AU - Ogunronbi, Mayowa
AU - Hamilton‐Nelson, Kara L
AU - Damasceno, Albertino
AU - Zaman, Andrew F
AU - Blanton, Susan H
AU - Akpalu, Albert
AU - Cuccaro, Michael L
AU - Wahab, Kolawole
AU - McInerney, Katalina F
AU - Nuytemans, Karen
AU - Obiako, Reginald
AU - Mena, Pedro R
AU - Okubadejo, Njideka
AU - Martinez, Izri M
AU - Zewde, Yared Z
AU - Gugssa, Seid A
AU - Sarfo, Fred S
AU - Kalaria, Raj
AU - Ndetei, David M
AU - Williams, Scott M
AU - Caban‐Holt, Allison
AU - ADGC, AfDC
AU - Tosto, Giuseppe
AU - Haines, Jonathan L
AU - Akinyemi, Rufus O
AU - Ogunniyi, Adesola
AU - Byrd, Goldie S
AU - Bush, William S
AU - Kunkle, Brian W
AU - Vance, Jeffery M
AU - Pericak‐Vance, Margaret A
AU - Reitz, Christiane
TI - Genetic correlation analysis of Alzheimer's disease and stroke implicates PHLPP1 as a shared locus in individuals of African ancestry
T2 - Alzheimer's & dementia : the journal of the Alzheimer's Association
J2 - Alzheimers Dement
PY - 2026
DA - 2026/04/01
VL - 22
IS - 4
SP - e71433
SN - 1552-5260
PB - Wiley
DO - 10.1002/alz.71433
UR - https://doi.org/10.1002/alz.71433
LA - en
ER -

CSL-JSON

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