Vulnerability of the locus coeruleus-entorhinal cortex white matter tract in autosomal dominant Alzheimer's disease.
Overview
- The Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
- Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA
- Department of Psychological and Brain Sciences, Boston University, Boston, Massachusetts, USA
- Grupo de Neurociencias de Antioquia, Universidad de Antioquia, Medellín, Antioquia, Colombia
- Department of Biomedical Engineering, University of Massachusetts Amherst, Amherst, Massachusetts, USA
- Department of Radiology, Hospital Pablo Tobón Uribe, Medellín, Antioquia, Colombia
Abstract
INTRODUCTION: Locus coeruleus (LC) structural integrity declines early in sporadic and autosomal dominant Alzheimer's disease (AD). We examined LC–entorhinal cortex (LC‐EC) tract integrity and its association with amyloid and tau pathology and memory in autosomal dominant AD (ADAD).
METHODS: We examined associations between diffusion‐weighted imaging‐derived LC‐EC tract characteristics and age, sex, amyloid (Pittsburgh Compound B [PiB]), entorhinal tau ([18F]‐flortaucipir [18F‐FTP] positron emission tomography [PET]), and memory in PSEN1‐E280A mutation carriers (n = 30) and non‐carriers (n = 33).
RESULTS: LC‐EC tract integrity was lower in females and older individuals in both non‐carriers and carriers. In mutation carriers, lower tract integrity was associated with higher entorhinal tau and poorer memory, with tau and amyloid mediating the tract‐memory relationship in the entire sample but not in unimpaired carriers.
DISCUSSION: These findings highlight the LC‐EC tract as an early disease vulnerability marker in ADAD, with tract disruption associated with memory decline across disease stages, a relationship further mediated by entorhinal tau pathology as disease progresses.
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Recorded: type, language, journal, volume, issue, pages, dates, 12 authors, 9 keywords, 16 MeSH terms, 7 funders, 54 references.
Cite
This paper
Koops, E. A., Giudicessi, A., Baena, A., Martinez, L., Bonillas‐Felix, N., Medrano, R., Dutta, J., Gonzalez, I., Alvarez, S., Aguillon, D., Quiroz, Y. T., & Jacobs, H. I. L. (2026). Vulnerability of the locus coeruleus-entorhinal cortex white matter tract in autosomal dominant Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association, 22(6), e71587. https://
BibTeX
@article{koops2026vulner
author = {Koops, Elouise A and Giudicessi, Averi and Baena, Ana and Martinez, Lusiana and Bonillas‐Felix, Nikole and Medrano, Randy and Dutta, Joyita and Gonzalez, Isabela and Alvarez, Sergio and Aguillon, David and Quiroz, Yakeel T and Jacobs, Heidi I L},
title = {{Vulnerability of the locus coeruleus-entorhinal cortex white matter tract in autosomal dominant Alzheimer's disease}},
journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
year = {2026},
month = jun,
volume = {22},
number = {6},
pages = {e71587},
publisher = {Wiley},
issn = {1552-5260},
doi = {10.1002/
url = {https://
pmid = {42273784},
pmcid = {PMC13254689}
}
RIS
TY - JOUR
AU - Koops, Elouise A
AU - Giudicessi, Averi
AU - Baena, Ana
AU - Martinez, Lusiana
AU - Bonillas‐Felix, Nikole
AU - Medrano, Randy
AU - Dutta, Joyita
AU - Gonzalez, Isabela
AU - Alvarez, Sergio
AU - Aguillon, David
AU - Quiroz, Yakeel T
AU - Jacobs, Heidi I L
TI - Vulnerability of the locus coeruleus-entorhinal cortex white matter tract in autosomal dominant Alzheimer's disease
T2 - Alzheimer's & dementia : the journal of the Alzheimer's Association
J2 - Alzheimers Dement
PY - 2026
DA - 2026/
VL - 22
IS - 6
SP - e71587
SN - 1552-5260
PB - Wiley
DO - 10.1002/
UR - https://
LA - en
ER -
CSL-JSON
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