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A combined artificial intelligence-wet lab approach identifies a pivotal role of the NAD<sup>+</sup>-mitophagy axis on aging and neurodegeneration.

Overview

Authors: Sofie Lautrup1,2, Shu‐qin Cao1, Xi Long3, Bonnie Hei Man Liu3, Beatriz Escobar‐Doncel1, Aristide Ferrante1,4, Johannes Frank1, Tomas Schmauck‐Medina1, Geoffrey Ho Duen Leung3, Kristina Xiao Liang5,6, Ning Lu5,6, Katerina Veverova7, Martin Vyhnalek7, Frank W Pun3, Alex Zhavoronkov3, Evandro Fei Fang1,2
ORCID iDs: Evandro Fei Fang
  1. Department of Clinical Molecular Biology, University of Oslo and Akershus University Hospital, Lørenskog, Norway
  2. The Norwegian Centre on Healthy Ageing (NO‐Age) and the Norwegian National anti‐Alzheimer's Disease (NO‐AD) Networks, Oslo, Norway
  3. Hong Kong Science and Technology Park, Insilico Medicine Hong Kong Ltd. New Territories, Hong Kong, China
  4. Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy
  5. Department of Biomedicine (IBM), University of Bergen, Bergen, Norway
  6. NorVita Med AS, Bergen, Norway
  7. Memory Clinic, Department of Neurology, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic
Institutions: University of Oslo (Norway); Akershus University Hospital (Norway); Norwegian National Centre for Ageing and Health (Norway); University of Foggia (Italy); University of Bergen (Norway); Charles University (Czechia); University Hospital in Motol (Czechia)
Journal: Alzheimer's & dementia : the journal of the Alzheimer's Association, volume 22, issue 8, article e71680
Dates: received 15 December 2025; accepted 6 June 2026; published online 21 August 2026; in print August 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1002/alz.71680 · PMID 42626968 · PMCID PMC13495064 · OpenAlex W7203903437
Open access: hybrid, a free copy (OpenAlex)
Status: data only
Categories: human (organism), C. elegans (organism), other condition (population), Alzheimer's / dementia (population), cellular / molecular (subfield)
Methods: Statistics, Connectivity
Keywords: AD, aging, ALS, artificial intelligence, HD, machine learning, mitophagy, NAD+, PandaOmics, PD
MeSH: Aging*, Artificial Intelligence*, Brain*, Mitophagy*, NAD*, Neurodegenerative Diseases*, Alzheimer Disease, Animals, Caenorhabditis elegans, Humans, Induced Pluripotent Stem Cells, Neurons (* major topic)
Topic: Sirtuins and Resveratrol in Medicine (Geriatrics and Gerontology, Medicine), according to OpenAlex
Funding: The South-Eastern Norway Regional Health Authority (Helse Sør-øst RHF) (#2020001, #2023093, #2021021); the Rosa sløyfe/Norwegian Cancer Society and Norwegian Breast Cancer Society (#207819); Research Council of Norway (#262175, #334361); Cure Alzheimer's Fund (#282952, #284930); Norges ForskningsrÃ¥d (#262175, #334361); Akershus University Hospital (#262960, #261973, #269901); Norwegian Health Association (#43622, #281956); Akershus Universitetssykehus (#261973, #262960, #269901); Czech Republic-Norway KAPPA programme (#TO01000215); Ellcome Leap's Dynamic Resilience Program (jointly funded by Temasek Trust) (#104617); Cure Alzheimer's Fund (#282952, #284930); Nasjonalforeningen for Folkehelsen (#43622, #281956); Czech Ministry of Health project (#NW26-04-00501); Alzheimer's Association (PTC-Gene-25-1439553); Civitan Norges Forskningsfond (#281931); National Natural Science Foundation of China (#81971327); HORIZON-TMA-MSCA-DN (#101073251); NordForsk Foundation (#119986); Alzheimer's Association (PTC‐Gene‐25‐1439553); Wellcome Trust
Citations: not cited yet (Europe PMC); 111 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Data availability statement

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  • it says that the data are available on request

Read it in the paper: doi.org/10.1002/alz.71680.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 16 authors, 10 keywords, 12 MeSH terms, 20 funders, 108 references.

Cite

This paper

Lautrup, S., Cao, S., Long, X., Liu, B. H. M., Escobar‐Doncel, B., Ferrante, A., Frank, J., Schmauck‐Medina, T., Leung, G. H. D., Liang, K. X., Lu, N., Veverova, K., Vyhnalek, M., Pun, F. W., Zhavoronkov, A., & Fang, E. F. (2026). A combined artificial intelligence-wet lab approach identifies a pivotal role of the NAD<sup>+</sup>-mitophagy axis on aging and neurodegeneration. Alzheimer's & dementia : the journal of the Alzheimer's Association, 22(8), e71680. https://doi.org/10.1002/alz.71680

BibTeX

@article{lautrup2026combined,
author = {Lautrup, Sofie and Cao, Shu‐qin and Long, Xi and Liu, Bonnie Hei Man and Escobar‐Doncel, Beatriz and Ferrante, Aristide and Frank, Johannes and Schmauck‐Medina, Tomas and Leung, Geoffrey Ho Duen and Liang, Kristina Xiao and Lu, Ning and Veverova, Katerina and Vyhnalek, Martin and Pun, Frank W and Zhavoronkov, Alex and Fang, Evandro Fei},
title = {{A combined artificial intelligence-wet lab approach identifies a pivotal role of the NAD\<sup\>+\</sup\>-mitophagy axis on aging and neurodegeneration}},
journal = {Alzheimer's \& dementia : the journal of the Alzheimer's Association},
year = {2026},
month = aug,
volume = {22},
number = {8},
pages = {e71680},
publisher = {Wiley},
issn = {1552-5260},
doi = {10.1002/alz.71680},
url = {https://doi.org/10.1002/alz.71680},
pmid = {42626968},
pmcid = {PMC13495064}
}

RIS

TY - JOUR
AU - Lautrup, Sofie
AU - Cao, Shu‐qin
AU - Long, Xi
AU - Liu, Bonnie Hei Man
AU - Escobar‐Doncel, Beatriz
AU - Ferrante, Aristide
AU - Frank, Johannes
AU - Schmauck‐Medina, Tomas
AU - Leung, Geoffrey Ho Duen
AU - Liang, Kristina Xiao
AU - Lu, Ning
AU - Veverova, Katerina
AU - Vyhnalek, Martin
AU - Pun, Frank W
AU - Zhavoronkov, Alex
AU - Fang, Evandro Fei
TI - A combined artificial intelligence-wet lab approach identifies a pivotal role of the NAD<sup>+</sup>-mitophagy axis on aging and neurodegeneration
T2 - Alzheimer's & dementia : the journal of the Alzheimer's Association
J2 - Alzheimers Dement
PY - 2026
DA - 2026/08/01
VL - 22
IS - 8
SP - e71680
SN - 1552-5260
PB - Wiley
DO - 10.1002/alz.71680
UR - https://doi.org/10.1002/alz.71680
LA - en
ER -

CSL-JSON

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"container-title": "Alzheimer's & dementia : the journal of the Alzheimer's Association",
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"container-title-short": "Alzheimers Dement",
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"DOI": "10.1002/alz.71680",
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"language": "en",
"issued": {
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