OSCR

Rhynchophylline rewires DLAT lipoylation <i>via</i> conformational control to reverse mitochondrial bioenergetic collapse against dopaminergic neuronal injury.

Overview

Authors: Xiaomin Liang1, Xunfang Yang1, Shuhui Wang1, Fangfang Zhuo1, Xingzi Hou1, Pengfei Tu1, Yang Liu2, Kewu Zeng1,3, Qingying Zhang1
  1. State Key Laboratory of Natural and Biomimetic Drugs and Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China
  2. Center of Basic Medical Research, Institute of Medical Innovation and Research, Peking University Third Hospital, Peking University, Beijing 100191, China
  3. Department of Integration of Chinese and Western Medicine, School of Basic Medical Sciences, Peking University, Beijing 100191, China
Institutions: Peking University (China); State Key Laboratory of Natural and Biomimetic Drugs (China); Peking University Third Hospital (China)
Journal: Acta pharmaceutica Sinica. B, volume 16, issue 8, pages 5276-5296
Dates: received 10 May 2025; accepted 19 October 2025; published online 11 June 2026; in print August 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1016/j.apsb.2026.06.016 · PMID 42592186 · PMCID PMC13464090 · OpenAlex W7164320021
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: genetics / omics (modality), Parkinson's (population), cellular / molecular (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, Preprocessing, Connectivity
Keywords: Rhynchophylline, DLAT, Lipoylation, Mitochondrial dynamics, Parkinson's disease, Neuroprotection, Target identification, Thermal proteome profiling
Topic: Biochemical Acid Research Studies (Biochemistry, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: National Natural Science Foundation of China (82325050, 82174008, 82574548, 82173951); China Postdoctoral Science Foundation (2024M760160); Natural Science Foundation of Beijing Municipality
Citations: not cited yet (Europe PMC); 65 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Versions

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Version 2, 28 September 2026

  • Funding: added National Natural Science Foundation of China: 82325050, 82174008, 82574548, 82173951; China Postdoctoral Science Foundation: 2024M760160; Natural Science Foundation of Beijing Municipality

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 9 authors, 8 keywords, 65 references.

Cite

This paper

Liang, X., Yang, X., Wang, S., Zhuo, F., Hou, X., Tu, P., Liu, Y., Zeng, K., & Zhang, Q. (2026). Rhynchophylline rewires DLAT lipoylation <i>via</i> conformational control to reverse mitochondrial bioenergetic collapse against dopaminergic neuronal injury. Acta pharmaceutica Sinica. B, 16(8), 5276-5296. https://doi.org/10.1016/j.apsb.2026.06.016

BibTeX

@article{liang2026rhynchophylline,
author = {Liang, Xiaomin and Yang, Xunfang and Wang, Shuhui and Zhuo, Fangfang and Hou, Xingzi and Tu, Pengfei and Liu, Yang and Zeng, Kewu and Zhang, Qingying},
title = {{Rhynchophylline rewires DLAT lipoylation \<i\>via\</i\> conformational control to reverse mitochondrial bioenergetic collapse against dopaminergic neuronal injury}},
journal = {Acta pharmaceutica Sinica. B},
year = {2026},
month = jun,
volume = {16},
number = {8},
pages = {5276--5296},
publisher = {Elsevier},
issn = {2211-3835},
doi = {10.1016/j.apsb.2026.06.016},
url = {https://doi.org/10.1016/j.apsb.2026.06.016},
pmid = {42592186},
pmcid = {PMC13464090}
}

RIS

TY - JOUR
AU - Liang, Xiaomin
AU - Yang, Xunfang
AU - Wang, Shuhui
AU - Zhuo, Fangfang
AU - Hou, Xingzi
AU - Tu, Pengfei
AU - Liu, Yang
AU - Zeng, Kewu
AU - Zhang, Qingying
TI - Rhynchophylline rewires DLAT lipoylation <i>via</i> conformational control to reverse mitochondrial bioenergetic collapse against dopaminergic neuronal injury
T2 - Acta pharmaceutica Sinica. B
J2 - Acta Pharm Sin B
PY - 2026
DA - 2026/06/11
VL - 16
IS - 8
SP - 5276
EP - 5296
SN - 2211-3835
PB - Elsevier
DO - 10.1016/j.apsb.2026.06.016
UR - https://doi.org/10.1016/j.apsb.2026.06.016
LA - en
ER -

CSL-JSON

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