Tau368 improves p-tau diagnostic accuracy for FTLD-tau from FTLD-TDP.
Overview
- Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, 431 80 Mölndal, Sweden
- Department of Pathology and Laboratory Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53726 USA
- Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA
- Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA
- Bioventix Plc, Farnham, GU9 7SX UK
- Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Institute on Aging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104 USA
- Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, 431 80 Mölndal, Sweden
- Department of Neurodegenerative Disease, Dementia Research Centre, Institute of Neurology, University College London, Queen Square, London, WC1E 6BT UK
- UK Dementia Research Institute, University College London, London, WC1E 6BT UK
- Centre for Brain Research, Indian Institute of Science, Bangalore, India
- Department of Neurosciences, University of California, San Diego, CA 92161 USA
- Eli Lilly and Company, Solna, Sweden
Abstract
Across tauopathies—Alzheimer’s disease (AD), frontotemporal lobar degeneration due to tau (FTLD-tau)—we compared cerebrospinal fluid (CSF) biomarkers of phosphorylated-tau (p-tau) p-tau181, p-tau212, tau368, total tau (t-tau), and the tau368/
Supplementary Information: The online version contains supplementary material available at 10.1007/
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
The paper says that its authors' code is available on request: it was not published with the paper, so there is nothing to verify.
Code availability
The codes used for the data analyses in this study can be requested from the corresponding author.
Reproduced under the paper's license (CC BY), from the paper cited above.
Tracing map
A tracing map links a paper to the code its authors published: this paper has none (its code is available on request), so it has no map.
Data
No dataset and no data link were found in the paper.
Data availability
Blinded anonymized data are available on reasonable request from the corresponding author. The request will be reviewed by the investigators and respective institutions to verify if data transfer is in agreement with EU legislation on general data protection or is subject to any intellectual property or confidentiality obligations.
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 2, 28 September 2026
- Publisher: n/a → Springer Science+Business Media
Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 16 authors, 6 keywords, 14 MeSH terms, 13 funders, 123 references.
Cite
This paper
Kac, P. R., Cousins, K. A. Q., Szadziewska, A., Shaw, L. M., Turton, M., Van Deerlin, V. M., Harrison, P., Zetterberg, H., Wolk, D. A., McMillan, C. T., Galasko, D., Hanrieder, J., Lee, E. B., Kvartsberg, H., Irwin, D. J., & Blennow, K. (2026). Tau368 improves p-tau diagnostic accuracy for FTLD-tau from FTLD-TDP. Acta neuropathologica, 151(1), 71. https://
BibTeX
@article{kac2026tau368,
author = {Kac, Przemysław R and Cousins, Katheryn A Q and Szadziewska, Alicja and Shaw, Leslie M and Turton, Michael and Van Deerlin, Vivianna M and Harrison, Peter and Zetterberg, Henrik and Wolk, David A and McMillan, Corey T and Galasko, Douglas and Hanrieder, Jörg and Lee, Edward B and Kvartsberg, Hlin and Irwin, David J and Blennow, Kaj},
title = {{Tau368 improves p-tau diagnostic accuracy for FTLD-tau from FTLD-TDP}},
journal = {Acta neuropathologica},
year = {2026},
month = jun,
volume = {151},
number = {1},
pages = {71},
publisher = {Springer Science+Business Media},
issn = {0001-6322},
doi = {10.1007/
url = {https://
pmid = {42340485},
pmcid = {PMC13294230}
}
RIS
TY - JOUR
AU - Kac, Przemysław R
AU - Cousins, Katheryn A Q
AU - Szadziewska, Alicja
AU - Shaw, Leslie M
AU - Turton, Michael
AU - Van Deerlin, Vivianna M
AU - Harrison, Peter
AU - Zetterberg, Henrik
AU - Wolk, David A
AU - McMillan, Corey T
AU - Galasko, Douglas
AU - Hanrieder, Jörg
AU - Lee, Edward B
AU - Kvartsberg, Hlin
AU - Irwin, David J
AU - Blennow, Kaj
TI - Tau368 improves p-tau diagnostic accuracy for FTLD-tau from FTLD-TDP
T2 - Acta neuropathologica
J2 - Acta Neuropathol
PY - 2026
DA - 2026/
VL - 151
IS - 1
SP - 71
SN - 0001-6322
PB - Springer Science+Business Media
DO - 10.1007/
UR - https://
LA - en
ER -
CSL-JSON
{
"id": "10.1007/
"type": "article-journal",
"title": "Tau368 improves p-tau diagnostic accuracy for FTLD-tau from FTLD-TDP",
"container-title": "Acta neuropathologica",
"author": [
{
"family": "Kac",
"given": "Przemysław R"
},
{
"family": "Cousins",
"given": "Katheryn A Q"
},
{
"family": "Szadziewska",
"given": "Alicja"
},
{
"family": "Shaw",
"given": "Leslie M"
},
{
"family": "Turton",
"given": "Michael"
},
{
"family": "Van Deerlin",
"given": "Vivianna M"
},
{
"family": "Harrison",
"given": "Peter"
},
{
"family": "Zetterberg",
"given": "Henrik"
},
{
"family": "Wolk",
"given": "David A"
},
{
"family": "McMillan",
"given": "Corey T"
},
{
"family": "Galasko",
"given": "Douglas"
},
{
"family": "Hanrieder",
"given": "Jörg"
},
{
"family": "Lee",
"given": "Edward B"
},
{
"family": "Kvartsberg",
"given": "Hlin"
},
{
"family": "Irwin",
"given": "David J"
},
{
"family": "Blennow",
"given": "Kaj"
}
],
"container-title-short":
"volume": "151",
"issue": "1",
"page": "71",
"DOI": "10.1007/
"PMID": "42340485",
"PMCID": "PMC13294230",
"ISSN": "0001-6322",
"publisher": "Springer Science+Business Media",
"URL": "https://
"language": "en",
"issued": {
"date-parts": [
[
2026,
6,
24
]
]
}
}
Similar papers
The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.
- [1] doi:10.1002/ana.78300
- Distribution of Big Tau Isoforms in the Human Central and Peripheral Nervous System.Journal: Annals of neurologyIn common: Alzheimer's / dementia, 10 references
- [2] doi:10.1093/brain/awaf375 [code]
- Reference proteins to improve Core 1 and Core 2 Alzheimer's disease CSF and plasma biomarkers.Journal: Brain : a journal of neurologyIn common: Alzheimer's / dementia, clinical / translational, 9 references
- [3] doi:10.1002/alz.71649 [code]
- Postmortem brain MRI reveals differential associations of subcortical and limbic volumes with cortical thinning and neurodegenerative pathologies.Journal: Alzheimer's & dementia : the journal of the Alzheimer's AssociationIn common: Parkinson's, Alzheimer's / dementia, 6 references
- [4] doi:10.1038/s41467-026-71732-1 [code]
- Trajectories of plasma and CSF MTBR-tau243 and phosphorylated-tau species across the Alzheimer's disease continuum.Journal: Nature communicationsIn common: Alzheimer's / dementia, 6 references
- [5] doi:10.1093/braincomms/fcag341
- Distinct and shared multimodal neuroimaging patterns in clinical frontotemporal dementia syndromes.Journal: Brain communicationsIn common: Alzheimer's / dementia, clinical / translational, 4 references
- [6] doi:10.1162/imag.a.1358
- Spatial covariance of mGluR5 density and structural degeneration in behavioral variant frontotemporal degeneration.Journal: Imaging neuroscience (Cambridge, Mass.)In common: Alzheimer's / dementia, 4 references
- [7] doi:10.1093/brain/awag131 [code]
- Data-driven modelling of tau pathology reveals distinct progressive supranuclear palsy subtypes.Journal: Brain : a journal of neurologyIn common: Alzheimer's / dementia, 5 references
- [8] doi:10.64898/2026.05.06.26352540 [code]
- Generating synthetic tau-PET scans in Alzheimer’s disease from MRI, blood biomarkers and demographics with deep learningJournal: medRxiv (preprint)In common: Alzheimer's / dementia, clinical / translational, 4 references
- [9] doi:10.1093/braincomms/fcag169 [code]
- Clinicoanatomic localization of iron-rich gliosis in aphasic presentations of globular glial tauopathy.Journal: Brain communicationsIn common: Alzheimer's / dementia, 4 references
- [10] doi:10.1016/j.nbd.2026.107379 [code]
- DYRK1A and Parkinson's disease, facts and hypotheses.Journal: Neurobiology of diseaseIn common: Parkinson's, Alzheimer's / dementia, 3 references
Contribute
The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.
Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.
Claim this paper
Correct its record
Say what each link of this record is, remove the ones that are not the paper's, add the ones that are missing. The correction becomes a new version of the record, in its Versions section.
Request its removal
To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).
Discussion, reproductions, activity
Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.
Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.
Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.