OSCR

SLC38A9 Regulation Affects Hippocampal Neuronal Autophagy: A Potential Alzheimer's Therapeutic Approach by Suppressing Alzheimer's Disease-Related Protein Deposition.

Overview

Authors: Yixin Chen1,2,3, Xueying Ji4, Jiaxiu Zhao1,2,3, Zhijun Bao1,2,3, Yiqin Huang4
ORCID iDs: Yixin Chen, Xueying Ji
  1. Department of Geriatrics, Huadong Hospital Affiliated to Fudan University, Shanghai, China
  2. Shanghai Key Laboratory of Clinical Geriatric Medicine, Shanghai, China
  3. Shanghai Institute of Geriatrics and Gerontology, Shanghai, China
  4. Department of General Practice, Huadong Hospital Affiliated to Fudan University, Shanghai, China
Institutions: Fudan University (China); Huadong Hospital (China)
Journal: CNS neuroscience & therapeutics, volume 32, issue 3, article e70823
Dates: received 3 November 2025; accepted 17 February 2026; published online 11 March 2026; in print March 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.1002/cns.70823 · PMID 41811103 · PMCID PMC12977986 · OpenAlex W7134933924
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: human (organism), mouse (organism), Alzheimer's / dementia (population), cellular / molecular (subfield)
Methods: Statistics, Evoked potentials
Keywords: alzheimer's disease, autophagy, mTOR/ULK‐1, SLC38A9
MeSH: Alzheimer Disease*, Autophagy*, Hippocampus*, Neurons*, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Animals, Disease Models, Animal, Humans, Mice, Mice, Transgenic, Peptide Fragments, Presenilin-1 (* major topic)
Topic: Alzheimer's disease research and treatments (Physiology, Medicine), according to OpenAlex
Funding: China Youth Medical Innovation Research Project; National Natural Science Foundation of China (82071581); Shanghai Leading Talent Program (2022002); Shanghai Municipal Health Commission Key Support Discipline Program (2023ZDFC0402)
Citations: not cited yet (Europe PMC); 38 references in the paper

Abstract

Aims: Impaired autophagy‐mediated clearance of Alzheimer's disease (AD)‐related proteins is a critical event in AD pathogenesis. SLC38A9, a member of the Solute Carrier 38 family, acts as an arginine sensor and plays an important role in regulating autophagy. Although the activation of autophagy regulated by the SLC38A9 may have a mitigating effect on AD, this aspect still awaits further exploration.

Methods: APP/PS1 mouse models and HT22 cells treated with amyloid‐β 25–35 (Aβ25–35) were transduced with vectors to evaluate the effect of SLC38A9 in AD.

Results: We show that decreasing SLC38A9 could promote the hippocampal neuronal autophagic clearance of AD‐related proteins, reduce neuronal apoptosis, and improve cognitive function.

Conclusion: Our results demonstrate SLC38A9 is involved in AD‐related pathology and its cognitive impairment, and may offer new therapeutic targets to AD.

Reproduced under the paper's license (CC BY), from the paper cited above.

Code

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Data

Datasets cited

Data Availability Statement

The datasets used and/or analyzed during the current study are available from the corresponding author upon reasonable request.

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 5 authors, 4 keywords, 13 MeSH terms, 4 funders, 38 references.

Cite

This paper

Chen, Y., Ji, X., Zhao, J., Bao, Z., & Huang, Y. (2026). SLC38A9 Regulation Affects Hippocampal Neuronal Autophagy: A Potential Alzheimer's Therapeutic Approach by Suppressing Alzheimer's Disease-Related Protein Deposition. CNS neuroscience & therapeutics, 32(3), e70823. https://doi.org/10.1002/cns.70823

BibTeX

@article{chen2026slc38a9,
author = {Chen, Yixin and Ji, Xueying and Zhao, Jiaxiu and Bao, Zhijun and Huang, Yiqin},
title = {{SLC38A9 Regulation Affects Hippocampal Neuronal Autophagy: A Potential Alzheimer's Therapeutic Approach by Suppressing Alzheimer's Disease-Related Protein Deposition}},
journal = {CNS neuroscience \& therapeutics},
year = {2026},
month = mar,
volume = {32},
number = {3},
pages = {e70823},
publisher = {Wiley},
issn = {1755-5930},
doi = {10.1002/cns.70823},
url = {https://doi.org/10.1002/cns.70823},
pmid = {41811103},
pmcid = {PMC12977986}
}

RIS

TY - JOUR
AU - Chen, Yixin
AU - Ji, Xueying
AU - Zhao, Jiaxiu
AU - Bao, Zhijun
AU - Huang, Yiqin
TI - SLC38A9 Regulation Affects Hippocampal Neuronal Autophagy: A Potential Alzheimer's Therapeutic Approach by Suppressing Alzheimer's Disease-Related Protein Deposition
T2 - CNS neuroscience & therapeutics
J2 - CNS Neurosci Ther
PY - 2026
DA - 2026/03/01
VL - 32
IS - 3
SP - e70823
SN - 1755-5930
PB - Wiley
DO - 10.1002/cns.70823
UR - https://doi.org/10.1002/cns.70823
LA - en
ER -

CSL-JSON

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"language": "en",
"issued": {
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}

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