TSPO-PET binding in vivo reflects increased phagocytic microglia at post mortem in people with frontotemporal dementia.
Overview
- Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK
- UK Dementia Research Institute, University of Cambridge, Cambridge, UK
- Cambridge University Hospitals NHS Trust, Cambridge, UK
- Department of Imaging and Pathology, University of Leuven, Louvain, Belgium
- Department of Psychiatry, University of Cambridge, Cambridge, UK
Abstract
Brain inflammation is a key feature of frontotemporal dementia (FTD). Positron emission tomography (PET) of the 18 kDa translocator protein (TSPO) is widely used as an in vivo proxy for neuroinflammation, but whether the elevated signal reflects microglial, astrocytic or vascular pathology remains controversial, and this has not previously been resolved in FTD using matched ante mortem imaging and post-mortem tissue. We paired ante mortem [11C]PK11195 TSPO–PET with quantitative post-mortem neuropathology in 10 individuals with FTD (5 FTLD-tau, 5 FTLD–TDP) and 5 age- and sex-matched controls, combining CD68 immunohistochemistry across 17 brain regions, multiplex immunofluorescence pairing TSPO with microglial/
Supplementary Information: The online version contains supplementary material available at https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
The paper says that its authors' code is available on request: it was not published with the paper, so there is nothing to verify.
Code availability
The R analysis code used to generate the results reported here is available from the corresponding author on reasonable request.
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data
No dataset and no data link were found in the paper.
Data availability
The data supporting the findings of this study are available from the corresponding author on reasonable request. Anonymised regional TSPO PET binding values and quantitative neuropathology measurements can be shared with qualified investigators, subject to the governance requirements of the Cambridge Brain Bank and the relevant Research Ethics Committee approvals. Post-mortem human brain tissue is available through the Cambridge Brain Bank in accordance with its tissue access policy.
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 1, 25 October 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 20 authors, 6 keywords, 15 MeSH terms, 9 funders, 43 references.
Cite
This paper
Vontobel, D. S., Lai, K. O., Bacioglu, M., Nolan, G., Maddison, D. C., Adamski, A., Goddard, J., Shapiro, N. L., Crook, H., Fryer, T., Hong, Y., Wijesinghe, S., Aigbirhio, F., Avezov, E., Allinson, K. S. J., Quaegebeur, A., O’Brien, J. T., Rowe, J. B., Spillantini, M. G., & Malpetti, M. (2026). TSPO-PET binding in vivo reflects increased phagocytic microglia at post mortem in people with frontotemporal dementia. Acta neuropathologica, 152(1), 59. https://
BibTeX
@article{vontobel2026tsp
author = {Vontobel, Davi S and Lai, Kei Onn and Bacioglu, Mehtap and Nolan, George and Maddison, Daniel C and Adamski, Amelie and Goddard, Julia and Shapiro, Noah L and Crook, Harry and Fryer, Tim and Hong, Young and Wijesinghe, Sasvi and Aigbirhio, Franklin and Avezov, Edward and Allinson, Kieren S J and Quaegebeur, Annelies and O’Brien, John T and Rowe, James B and Spillantini, Maria Grazia and Malpetti, Maura},
title = {{TSPO-PET binding in vivo reflects increased phagocytic microglia at post mortem in people with frontotemporal dementia}},
journal = {Acta neuropathologica},
year = {2026},
month = oct,
volume = {152},
number = {1},
pages = {59},
publisher = {Springer Science+Business Media},
issn = {0001-6322},
doi = {10.1007/
url = {https://
pmid = {42911238},
pmcid = {PMC13690867}
}
RIS
TY - JOUR
AU - Vontobel, Davi S
AU - Lai, Kei Onn
AU - Bacioglu, Mehtap
AU - Nolan, George
AU - Maddison, Daniel C
AU - Adamski, Amelie
AU - Goddard, Julia
AU - Shapiro, Noah L
AU - Crook, Harry
AU - Fryer, Tim
AU - Hong, Young
AU - Wijesinghe, Sasvi
AU - Aigbirhio, Franklin
AU - Avezov, Edward
AU - Allinson, Kieren S J
AU - Quaegebeur, Annelies
AU - O’Brien, John T
AU - Rowe, James B
AU - Spillantini, Maria Grazia
AU - Malpetti, Maura
TI - TSPO-PET binding in vivo reflects increased phagocytic microglia at post mortem in people with frontotemporal dementia
T2 - Acta neuropathologica
J2 - Acta Neuropathol
PY - 2026
DA - 2026/
VL - 152
IS - 1
SP - 59
SN - 0001-6322
PB - Springer Science+Business Media
DO - 10.1007/
UR - https://
LA - en
ER -
CSL-JSON
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"author": [
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"family": "Vontobel",
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