OSCR

Microglia Attenuate Neuroinflammation After Subarachnoid Hemorrhage by Modulating Astrocyte Phenotypic Transformation via the RARα/Mafb/Msr1 Pathway.

Overview

Authors: Yuxiao Meng1, Yuanzhe Dong1, Jiang Shao2, Qiaowei Wu3, Le Huang1, Pei Wu1, Shuai Lan1, Zurong Yao1, Huaizhang Shi1, Yuchen Li1
  1. Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, 150000 China
  2. Department of Neurosurgery, Linyi People’s Hospital, Linyi, 276000 China
  3. Department of Neurosurgery, Hunan University of Medicine General Hospital, Huaihua, 418000 China
Institutions: First Affiliated Hospital of Harbin Medical University (China); Linyi People's Hospital (China); Hunan University of Medicine (China)
Journal: Molecular neurobiology, volume 63, issue 1, article 675
Dates: received 26 November 2025; accepted 22 May 2026; published online 5 June 2026; in print 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1007/s12035-026-05965-y · PMID 42243462 · PMCID PMC13236732 · OpenAlex W7163526586
Open access: hybrid, a free copy (OpenAlex)
Status: data only
Categories: rat (organism), stroke (population), cellular / molecular (subfield)
Methods: Statistics, Preprocessing, Graphs
Keywords: Subarachnoid hemorrhage, Astrocyte, Microglial, Neuroinflammation, Retinoic acid receptor α
MeSH: Astrocytes*, MafB Transcription Factor*, Microglia*, Neuroinflammatory Diseases*, Retinoic Acid Receptor alpha*, Signal Transduction*, Subarachnoid Hemorrhage*, Animals, Benzoates, Male, Phenotype, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins c-akt, Rats, Rats, Sprague-Dawley, Tetrahydronaphthalenes (* major topic)
Topic: Neuroinflammation and Neurodegeneration Mechanisms (Neurology, Neuroscience), according to OpenAlex
Funding: National Natural Science Foundation of China (82071309)
Citations: not cited yet (Europe PMC); 55 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper links to its data, not to its authors' code: see the Data section.

Tracing map

A tracing map links a paper to the code its authors published: this paper has none, so it has no map.

Data

Datasets cited

Other data links

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • no repository, dataset or request procedure was recognized in it

Read it in the paper: doi.org/10.1007/s12035-026-05965-y.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 2, 28 September 2026

  • Publisher: n/a → Springer Science+Business Media
  • Funding: added National Natural Science Foundation of China: 82071309

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 10 authors, 5 keywords, 16 MeSH terms, 55 references.

Cite

This paper

Meng, Y., Dong, Y., Shao, J., Wu, Q., Huang, L., Wu, P., Lan, S., Yao, Z., Shi, H., & Li, Y. (2026). Microglia Attenuate Neuroinflammation After Subarachnoid Hemorrhage by Modulating Astrocyte Phenotypic Transformation via the RARα/Mafb/Msr1 Pathway. Molecular neurobiology, 63(1), 675. https://doi.org/10.1007/s12035-026-05965-y

BibTeX

@article{meng2026microglia,
author = {Meng, Yuxiao and Dong, Yuanzhe and Shao, Jiang and Wu, Qiaowei and Huang, Le and Wu, Pei and Lan, Shuai and Yao, Zurong and Shi, Huaizhang and Li, Yuchen},
title = {{Microglia Attenuate Neuroinflammation After Subarachnoid Hemorrhage by Modulating Astrocyte Phenotypic Transformation via the RARα/Mafb/Msr1 Pathway}},
journal = {Molecular neurobiology},
year = {2026},
month = jun,
volume = {63},
number = {1},
pages = {675},
publisher = {Springer Science+Business Media},
issn = {0893-7648},
doi = {10.1007/s12035-026-05965-y},
url = {https://doi.org/10.1007/s12035-026-05965-y},
pmid = {42243462},
pmcid = {PMC13236732}
}

RIS

TY - JOUR
AU - Meng, Yuxiao
AU - Dong, Yuanzhe
AU - Shao, Jiang
AU - Wu, Qiaowei
AU - Huang, Le
AU - Wu, Pei
AU - Lan, Shuai
AU - Yao, Zurong
AU - Shi, Huaizhang
AU - Li, Yuchen
TI - Microglia Attenuate Neuroinflammation After Subarachnoid Hemorrhage by Modulating Astrocyte Phenotypic Transformation via the RARα/Mafb/Msr1 Pathway
T2 - Molecular neurobiology
J2 - Mol Neurobiol
PY - 2026
DA - 2026/06/05
VL - 63
IS - 1
SP - 675
SN - 0893-7648
PB - Springer Science+Business Media
DO - 10.1007/s12035-026-05965-y
UR - https://doi.org/10.1007/s12035-026-05965-y
LA - en
ER -

CSL-JSON

{
"id": "10.1007/s12035-026-05965-y",
"type": "article-journal",
"title": "Microglia Attenuate Neuroinflammation After Subarachnoid Hemorrhage by Modulating Astrocyte Phenotypic Transformation via the RARα/Mafb/Msr1 Pathway",
"container-title": "Molecular neurobiology",
"author": [
{
"family": "Meng",
"given": "Yuxiao"
},
{
"family": "Dong",
"given": "Yuanzhe"
},
{
"family": "Shao",
"given": "Jiang"
},
{
"family": "Wu",
"given": "Qiaowei"
},
{
"family": "Huang",
"given": "Le"
},
{
"family": "Wu",
"given": "Pei"
},
{
"family": "Lan",
"given": "Shuai"
},
{
"family": "Yao",
"given": "Zurong"
},
{
"family": "Shi",
"given": "Huaizhang"
},
{
"family": "Li",
"given": "Yuchen"
}
],
"container-title-short": "Mol Neurobiol",
"volume": "63",
"issue": "1",
"page": "675",
"DOI": "10.1007/s12035-026-05965-y",
"PMID": "42243462",
"PMCID": "PMC13236732",
"ISSN": "0893-7648",
"publisher": "Springer Science+Business Media",
"URL": "https://doi.org/10.1007/s12035-026-05965-y",
"language": "en",
"issued": {
"date-parts": [
[
2026,
6,
5
]
]
}
}

Similar papers

The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.

[1] doi:10.1186/s13062-026-00912-2
Integrated analysis of single-cell transcriptome identifies a glial-neurovascular signaling trajectory in brain repair after ischemia.
Journal: Biology direct
In common: rat, stroke, cellular / molecular, 4 references
[2] doi:10.1186/s12974-026-03837-9
PTP1B in astrocytes drives pathogen-induced neurodegeneration.
Journal: Journal of neuroinflammation
In common: cellular / molecular, 4 references
[3] doi:10.1186/s13195-026-02121-5
HDAC7 acts as an astrocytic mediator of Aβ pathology that directly engages IKK to drive astrocyte neurotoxicity and neurodegeneration in Alzheimer's disease.
Journal: Alzheimer's research & therapy
In common: cellular / molecular, 3 references
[4] doi:10.1186/s13229-026-00717-0 [code]
JUND-driven stress-responsive astrocytes promote neuronal apoptosis via enhanced gap junction signaling in autism spectrum disorder.
Journal: Molecular autism
In common: cellular / molecular, 3 references
[5] doi:10.1167/iovs.67.5.73 [code]
Identification of a Small-Molecule Modulator of Astrocyte Reactivity for Optic Nerve Protection.
Journal: Investigative ophthalmology & visual science
In common: cellular / molecular, 3 references
[6] doi:10.1038/s41593-026-02354-5 [code]
Focal astrocyte loss reveals nuclear translocation during lesion repopulation.
Journal: Nature neuroscience
In common: cellular / molecular, 3 references
[7] doi:10.1016/j.cell.2026.05.047 [code]
An emergent disease-associated motor neuron state precedes cell death in ALS.
Journal: Cell
In common: cellular / molecular, 2 references
[8] doi:10.1111/nan.70097
Transgenic A53T Mice Have Astrocytic α-Synuclein Aggregates in Dopamine and Striatal Regions.
Journal: Neuropathology and applied neurobiology
In common: cellular / molecular, 2 references
[9] doi:10.1186/s13024-026-00956-y [code]
In vivo profiling of astrocyte secretome reveals brain-region specific regulatory networks in a mouse model of amyloid pathology.
Journal: Molecular neurodegeneration
In common: cellular / molecular, 2 references
[10] doi:10.1126/sciadv.adt2527
NPAS3-regulated astrocyte mitochondrial bioenergetics is required for cognition.
Journal: Science advances
In common: cellular / molecular, 2 references

Contribute

The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.

Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.

Request its removal

To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).

Discussion, reproductions, activity

Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.

Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.

Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.