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Adhesion differentials control the rheology of biomimetic emulsions.

Overview

Authors: Quentin Guigue1,2,3, Marc Besse1,2, Raphael Voituriez1,2, Alexis M. Prevost1,2, Elie Wandersman1,2, Matthias Merkel4, Lea-Laetitia Pontani1,2
ORCID iDs: Quentin Guigue, Lea-Laetitia Pontani
  1. Sorbonne Université, CNRS, Laboratoire Jean Perrin, LJP, Paris, France
  2. Sorbonne Université, CNRS, Inserm, Institut de Biologie Paris-Seine, IBPS, Paris, France
  3. Aix Marseille Univ, CNRS, CINAM, Turing Centre for Living Systems, Marseille, France
  4. Aix Marseille Univ, Université de Toulon, CNRS, CPT (UMR 7332), Turing Center for Living Systems, Marseille, France
Institutions: Centre National de la Recherche Scientifique (France); Inserm (France); Aix-Marseille Université (France); Sorbonne Université (France); Laboratoire Jean Perrin (France); Institut de Biologie Paris-Seine (France); Centre Interdisciplinaire de Nanoscience de Marseille (France); Université de Toulon (France); Centre de Physique Théorique (France)
Journal: Biophysical journal, volume 125, issue 7, pages 1686-1700
Dates: received 8 November 2025; accepted 2 March 2026; published online 5 March 2026; in print 7 April 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.1016/j.bpj.2026.03.004 · PMID 41793006 · PMCID PMC13351756 · OpenAlex W4416176597
Open access: hybrid, a free copy (OpenAlex)
Preprint: arxiv:2503.18782
Status: data only
Categories: cellular / molecular (subfield)
MeSH: Biomimetic Materials*, Biomimetics*, Rheology*, Animals, Cell Adhesion, Emulsions (* major topic)
Topic: Cellular Mechanics and Interactions (Cell Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: Ville de Paris
Citations: not cited yet (Europe PMC); 80 references in the paper

Abstract

Animal morphogenesis involves complex tissue deformation processes, which require tight control over tissue rheology. Yet, it remains insufficiently understood how tissue rheology results from the interplay between cellular packing and forces, such as cortical tension or cell-cell adhesion. We follow a biomimetic approach to study this interplay, using oil droplets with tunable adhesion strength to mimic adhesive cells. We expose emulsions to cyclic shear and use a geometric method to quantify their rheology using only imaging data. We find that emulsions made of two droplet types change yielding behavior across subsequent shear cycles. Combining this with vertex model simulations, we show that this shift is due to a progressive compaction, which only occurs with a high adhesion differential and only under oscillatory shear. Our work thus demonstrates how gradients observed during development can lead to gradients in tissue rheology. Moreover, progressive compaction suggests the emergence of a pumping mechanism, which potentially acts in many cellular materials, from foams to tissues.

Reproduced under the paper's license (CC BY), from the paper cited above.

Code

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Data

Datasets cited

Data and code availability

Data have been deposited on Zenodo under the https://doi.org/10.5281/zenodo.15585808 and are publicly available as of the article publication date.

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

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Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 7 authors, 6 MeSH terms, 1 funder, 62 references.

Cite

This paper

Guigue, Q., Besse, M., Voituriez, R., Prevost, A. M., Wandersman, E., Merkel, M., & Pontani, L.-L. (2026). Adhesion differentials control the rheology of biomimetic emulsions. Biophysical journal, 125(7), 1686-1700. https://doi.org/10.1016/j.bpj.2026.03.004

BibTeX

@article{guigue2026adhesion,
author = {Guigue, Quentin and Besse, Marc and Voituriez, Raphael and Prevost, Alexis M. and Wandersman, Elie and Merkel, Matthias and Pontani, Lea-Laetitia},
title = {{Adhesion differentials control the rheology of biomimetic emulsions}},
journal = {Biophysical journal},
year = {2026},
month = mar,
volume = {125},
number = {7},
pages = {1686--1700},
publisher = {The Biophysical Society},
issn = {0006-3495},
doi = {10.1016/j.bpj.2026.03.004},
url = {https://doi.org/10.1016/j.bpj.2026.03.004},
pmid = {41793006},
pmcid = {PMC13351756}
}

RIS

TY - JOUR
AU - Guigue, Quentin
AU - Besse, Marc
AU - Voituriez, Raphael
AU - Prevost, Alexis M.
AU - Wandersman, Elie
AU - Merkel, Matthias
AU - Pontani, Lea-Laetitia
TI - Adhesion differentials control the rheology of biomimetic emulsions
T2 - Biophysical journal
J2 - Biophys J
PY - 2026
DA - 2026/03/05
VL - 125
IS - 7
SP - 1686
EP - 1700
SN - 0006-3495
PB - The Biophysical Society
DO - 10.1016/j.bpj.2026.03.004
UR - https://doi.org/10.1016/j.bpj.2026.03.004
LA - en
ER -

CSL-JSON

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