Targeting the SIRT6-TDO2/KYNA-mTOR axis rescues synaptic and cognitive deficits in fetal growth restriction offspring.
Overview
- Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Shanghai Key Laboratory of Maternal Fetal Medicine, Frontier Science Center for Stem Cell Research, National Stem Cell Translational Resource Center, School of Life Sciences and Technology, Tongji University, Shanghai, China
- Department of Medicine, Jinggangshan University, Ji’an, China
Abstract
Fetal growth restriction (FGR), a major perinatal complication, is causally linked to lifelong cognitive deficits in offspring; however, its underlying mechanisms remain poorly defined. Here, the SIRT6–TDO2/
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
The paper links to its data, not to its authors' code: see the Data section.
Tracing map
A tracing map links a paper to the code its authors published: this paper has none, so it has no map.
Data
Datasets cited
- geo:GSE298372, at NCBI GEO; found in “Data availability”
Data availability
RNA-sequencing data have been deposited in the GEO database under the accession number GSE298372 (https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 7 authors, 2 keywords, 13 MeSH terms, 1 funder, 110 references.
Cite
This paper
Chang, S., Chen, W., Zhu, W., Liu, N., Wang, Y., Li, J., & Kang, J. (2026). Targeting the SIRT6-TDO2/
BibTeX
@article{chang2026target
author = {Chang, Shujuan and Chen, Wen and Zhu, Wei and Liu, Nana and Wang, Yuhang and Li, Jianguo and Kang, Jiuhong},
title = {{Targeting the SIRT6-TDO2/
journal = {Experimental \& molecular medicine},
year = {2026},
month = jun,
volume = {58},
number = {6},
pages = {1987--2006},
publisher = {Korean Society for Biochemistry and Molecular Biology},
issn = {1226-3613},
doi = {10.1038/
url = {https://
pmid = {42277466},
pmcid = {PMC13324384}
}
RIS
TY - JOUR
AU - Chang, Shujuan
AU - Chen, Wen
AU - Zhu, Wei
AU - Liu, Nana
AU - Wang, Yuhang
AU - Li, Jianguo
AU - Kang, Jiuhong
TI - Targeting the SIRT6-TDO2/
T2 - Experimental & molecular medicine
J2 - Exp Mol Med
PY - 2026
DA - 2026/
VL - 58
IS - 6
SP - 1987
EP - 2006
SN - 1226-3613
PB - Korean Society for Biochemistry and Molecular Biology
DO - 10.1038/
UR - https://
LA - en
ER -
CSL-JSON
{
"id": "10.1038/
"type": "article-journal",
"title": "Targeting the SIRT6-TDO2/
"container-title": "Experimental & molecular medicine",
"author": [
{
"family": "Chang",
"given": "Shujuan"
},
{
"family": "Chen",
"given": "Wen"
},
{
"family": "Zhu",
"given": "Wei"
},
{
"family": "Liu",
"given": "Nana"
},
{
"family": "Wang",
"given": "Yuhang"
},
{
"family": "Li",
"given": "Jianguo"
},
{
"family": "Kang",
"given": "Jiuhong"
}
],
"container-title-short":
"volume": "58",
"issue": "6",
"page": "1987-2006",
"DOI": "10.1038/
"PMID": "42277466",
"PMCID": "PMC13324384",
"ISSN": "1226-3613",
"publisher": "Korean Society for Biochemistry and Molecular Biology",
"URL": "https://
"language": "en",
"issued": {
"date-parts": [
[
2026,
6,
11
]
]
}
}
Similar papers
The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.
- [1] doi:10.1186/s40478-026-02399-4
- Overactive EAAT1 Cl&
lt;sup& gt;-& lt;/ sup& gt; channels impair GABAergic tonic inhibition in SLC1A3-associated episodic ataxia. Journal: Acta neuropathologica communicationsIn common: mouse, cellular / molecular, 1 reference - [2] doi:10.1111/jnc.70502 [code]
- The Converging Effects of Different Categories of Antidepressants on the Brain: A Systematic Meta-Analysis of Public Transcriptional Profiling Data From the Hippocampus and Cortex.Journal: Journal of neurochemistryIn common: mouse, cellular / molecular, 1 reference
- [3] doi:10.1186/s12974-026-03796-1 [code]
- Tryptophan-kynurenine metabolic reprogramming along the gut-brain axis alleviates Alzheimer's pathology.Journal: Journal of neuroinflammationIn common: mouse, cellular / molecular, 1 reference
- [4] doi:10.1038/s44319-026-00846-w
- GATOR1 signaling defects promote astrocytic metabolic rewiring and excitatory neurotransmitter cycling.Journal: EMBO reportsIn common: mouse, cellular / molecular, 1 reference
- [5] doi:10.1080/21505594.2026.2697518
- Encephalomyocarditis virus impairs the blood-brain barrier by degrading tight junction proteins via AKT3-dependent autophagic and apoptotic pathways.Journal: VirulenceIn common: mouse, cellular / molecular, 1 reference
- [6] doi:10.1002/cns.70848
- Non-Invasive Temporal Interference Electrical Stimulation Modulates Neurotransmitter Release and Improves Aberrant Neural Oscillations in Alzheimer's Disease.Journal: CNS neuroscience & therapeuticsIn common: mouse, cellular / molecular, 1 reference
- [7] doi:10.1038/s44318-026-00809-w
- Genetic ablation of neuronal mitochondrial calcium uptake impedes Alzheimer's disease progression.Journal: The EMBO journalIn common: mouse, cellular / molecular, 1 reference
- [8] doi:10.1038/s42003-026-10182-3
- Caloric restriction decelerates premature aging and cognitive decline in mice with deficient DNA repair.Journal: Communications biologyIn common: mouse, cellular / molecular, 1 reference
- [9] doi:10.3390/antiox15070882
- &
lt;i& gt;Lactobacillus reuteri& lt;/ i& gt; DSM 17938 and Its Supernatant Ameliorate Parkinson's Disease in Association with Modulation of Gut Microbiota and Its Tryptophan Metabolism. Journal: Antioxidants (Basel, Switzerland)In common: mouse, 1 reference - [10] doi:10.1038/s41598-026-41942-0
- Non-severe burn injury leads to sustained molecular changes in the brain in a murine model.Journal: Scientific reportsIn common: mouse, 1 reference
Contribute
The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.
Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.
Claim this paper
Correct its record
Say what each link of this record is, remove the ones that are not the paper's, add the ones that are missing. The correction becomes a new version of the record, in its Versions section.
Request its removal
To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).
Discussion, reproductions, activity
Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.
Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.
Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.