Non-Invasive Temporal Interference Electrical Stimulation Modulates Neurotransmitter Release and Improves Aberrant Neural Oscillations in Alzheimer's Disease.
Overview
- School of Rehabilitation Sciences and Engineering University of Health and Rehabilitation Sciences Qingdao China
- The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Institute of Health and Rehabilitation Science, School of Life Science and Technology Xi'an Jiaotong University Xi'an Shaanxi P. R. China
- The Key Laboratory of Neuro‐Informatics & Rehabilitation Engineering of Ministry of Civil Affairs Xi'an Shaanxi P. R. China
Abstract
Background: Modulating brain oscillations has significant therapeutic promise. Traditional non‐invasive neuromodulation techniques can alleviate clinical signs of Alzheimer's disease (AD) by restoring normal neural oscillatory activity in certain brain regions. As a novel non‐invasive brain modulation technique, temporal interference (TI) has been demonstrated to precisely control hippocampus neural oscillations while minimizing its impact on cortical neural activity, but its exact mechanism of action is still unclear.
Method: We simulated and experimentally measured the intracranial electric field under TI to determine the precision of TI intervention. Subsequently, TI stimulation was applied to the APP/
Results: This work showed that in the APP/
Conclusions: The results of our work demonstrated how TI stimulation alters brain oscillations to enhance memory in mice with Alzheimer's disease, offering a possible theoretical foundation for TI's clinical application.
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
The paper says that its authors' code is available on request: it was not published with the paper, so there is nothing to verify.
The paper's code and data availability statement is in the Data section.
Tracing map
A tracing map links a paper to the code its authors published: this paper has none (its code is available on request), so it has no map.
Data
No dataset and no data link were found in the paper.
Data Availability Statement
Due to the large file size, the data sets generated and analyzed during the current study are available from the corresponding author upon request. Custom Matlab code that was used to analyze is available from the corresponding author upon request.
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 8 authors, 4 keywords, 11 MeSH terms, 6 funders, 44 references.
Cite
This paper
Wu, L., Li, S., Huang, L., Li, L., Zhou, P., Lu, Z., Liu, T., & Wang, J. (2026). Non-Invasive Temporal Interference Electrical Stimulation Modulates Neurotransmitter Release and Improves Aberrant Neural Oscillations in Alzheimer's Disease. CNS neuroscience & therapeutics, 32(5), e70848. https://
BibTeX
@article{wu2026non,
author = {Wu, Linyan and Li, Sinan and Huang, Liang and Li, Long and Zhou, Ping and Lu, Zhiyuan and Liu, Tian and Wang, Jue},
title = {{Non-Invasive Temporal Interference Electrical Stimulation Modulates Neurotransmitter Release and Improves Aberrant Neural Oscillations in Alzheimer's Disease}},
journal = {CNS neuroscience \& therapeutics},
year = {2026},
month = may,
volume = {32},
number = {5},
pages = {e70848},
publisher = {Wiley},
issn = {1755-5930},
doi = {10.1002/
url = {https://
pmid = {42084363},
pmcid = {PMC13141679}
}
RIS
TY - JOUR
AU - Wu, Linyan
AU - Li, Sinan
AU - Huang, Liang
AU - Li, Long
AU - Zhou, Ping
AU - Lu, Zhiyuan
AU - Liu, Tian
AU - Wang, Jue
TI - Non-Invasive Temporal Interference Electrical Stimulation Modulates Neurotransmitter Release and Improves Aberrant Neural Oscillations in Alzheimer's Disease
T2 - CNS neuroscience & therapeutics
J2 - CNS Neurosci Ther
PY - 2026
DA - 2026/
VL - 32
IS - 5
SP - e70848
SN - 1755-5930
PB - Wiley
DO - 10.1002/
UR - https://
LA - en
ER -
CSL-JSON
{
"id": "10.1002/
"type": "article-journal",
"title": "Non-Invasive Temporal Interference Electrical Stimulation Modulates Neurotransmitter Release and Improves Aberrant Neural Oscillations in Alzheimer's Disease",
"container-title": "CNS neuroscience & therapeutics",
"author": [
{
"family": "Wu",
"given": "Linyan"
},
{
"family": "Li",
"given": "Sinan"
},
{
"family": "Huang",
"given": "Liang"
},
{
"family": "Li",
"given": "Long"
},
{
"family": "Zhou",
"given": "Ping"
},
{
"family": "Lu",
"given": "Zhiyuan"
},
{
"family": "Liu",
"given": "Tian"
},
{
"family": "Wang",
"given": "Jue"
}
],
"container-title-short":
"volume": "32",
"issue": "5",
"page": "e70848",
"DOI": "10.1002/
"PMID": "42084363",
"PMCID": "PMC13141679",
"ISSN": "1755-5930",
"publisher": "Wiley",
"URL": "https://
"language": "en",
"issued": {
"date-parts": [
[
2026,
5,
1
]
]
}
}
Similar papers
The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.
- [1] doi:10.3390/bioengineering13070741
- Mapping the Global Trajectory and Key Trends of Temporal Interference Stimulation.Journal: Bioengineering (Basel, Switzerland)In common: 3 references
- [2] doi:10.1002/alz.71547
- Cortical synchrony is reduced in Alzheimer's disease and relates to arousal state.Journal: Alzheimer's & dementia : the journal of the Alzheimer's AssociationIn common: Alzheimer's / dementia, 3 references
- [3] doi:10.1016/j.celrep.2026.117505 [code]
- Impaired spatial coding and neuronal hyperactivity in the medial entorhinal cortex of aged APP knock-in mice.Journal: Cell reportsIn common: Alzheimer's / dementia, mouse, 2 references
- [4] doi:10.1002/advs.202524341 [code]
- Temporal Interference Stimulation Enhances Neural Regeneration.Journal: Advanced science (Weinheim, Baden-Wurttemberg, Germany)In common: Alzheimer's / dementia, mouse, 2 references
- [5] doi:10.1038/s41467-025-62798-4 [code]
- Distinct manifestations of excitatory-inhibitory imbalance associated with amyloid-β and tau in patients with Alzheimer’s diseaseJournal: n/aIn common: Alzheimer's / dementia, 2 references
- [6] doi:10.3389/fnagi.2026.1789422
- Short-term neurovascular and electrophysiological responses to combined visual and vibration stimulation in older adults with mild cognitive impairment.Journal: Frontiers in aging neuroscienceIn common: Alzheimer's / dementia, 2 references
- [7] doi:10.1002/alz.71570
- Stable neuronal representations underlie cognitive resilience to Alzheimer's disease pathology.Journal: Alzheimer's & dementia : the journal of the Alzheimer's AssociationIn common: Alzheimer's / dementia, 2 references
- [8] doi:10.3389/fnagi.2026.1882681
- Predominantly left-lateralized EEG-EMG associations following gamma-theta stimulation in older adults with mild cognitive impairment.Journal: Frontiers in aging neuroscienceIn common: Alzheimer's / dementia, 2 references
- [9] doi:10.1093/sleepadvances/zpag069 [code]
- Thalamic transcranial electrical stimulation with temporal interference enhances sleep spindle activity during a daytime nap.Journal: Sleep advances : a journal of the Sleep Research SocietyIn common: 2 references
- [10] doi:10.1038/s41467-026-73826-2 [code]
- Non-invasive in vivo acoustoelectric neuromodulation and its contribution to ultrasound stimulation.Journal: Nature communicationsIn common: mouse, 2 references
Contribute
The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.
Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.
Claim this paper
Correct its record
Say what each link of this record is, remove the ones that are not the paper's, add the ones that are missing. The correction becomes a new version of the record, in its Versions section.
Request its removal
To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).
Discussion, reproductions, activity
Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.
Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.
Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.