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Bulk and single-cell transcriptomic brain data identify overlapping processes and cell-types with human AUD and mammalian models of alcohol use.

Overview

Authors: Spencer B Huggett1, Sharmila Selveraj1, John E McGeary2,3, Ami S Ikeda1, Emerald Yuan1, Lauren B Loeffel4,5, Rohan H C Palmer1,3
ORCID iDs: Lauren B Loeffel, Rohan H C Palmer
  1. Behavioral Genetics of Addiction Laboratory, Department of Psychology at Emory University, Atlanta, GA USA
  2. Department of Psychiatry, Alpert Medical School of Brown University, Providence, RI USA
  3. Providence VA Medical Center, Providence, RI USA
  4. VA Boston Healthcare System, Boston, MA USA
  5. Department of Psychiatry, Boston University Chobanian & Avedisian School of Medicine, Boston, MA USA
Institutions: Emory University (United States); Brown University (United States); Providence VA Medical Center (United States); Boston University (United States); VA Boston Healthcare System (United States)
Journal: Translational psychiatry, volume 16, issue 1, article 212
Dates: received 26 March 2025; accepted 18 February 2026; published online 27 March 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41398-026-03919-5 · PMID 41896532 · PMCID PMC13039797 · OpenAlex W7141007446
Open access: gold, a free copy (OpenAlex)
Status: code on request (how the code is found and verified)
Categories: genetics / omics (modality), human (organism), mouse (organism), other condition (population), cellular / molecular (subfield)
Methods: Statistics, Preprocessing, Connectivity, Spectral & time-frequency
Keywords: Genetics, Genomics, Addiction
MeSH: Alcoholism*, Brain*, Nucleus Accumbens*, Prefrontal Cortex*, Transcriptome*, Animals, Disease Models, Animal, Female, Humans, Male, Mice, Oligodendroglia, Single-Cell Analysis, Single-Cell Gene Expression Analysis (* major topic)
Topic: Neurotransmitter Receptor Influence on Behavior (Cellular and Molecular Neuroscience, Neuroscience), according to OpenAlex
Funding: U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (DP1DA042103, R01DA037927); U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) (DP1DA042103, R01DA037927); NIAAA NIH HHS (R28 AA012725)
Citations: not cited yet (Europe PMC); 42 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

The paper says that its authors' code is available on request: it was not published with the paper, so there is nothing to verify.

Code availability statement

The paper has a code availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it says that the code is available on request

Read it in the paper: doi.org/10.1038/s41398-026-03919-5.

Tracing map

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Data

Datasets cited

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1038/s41398-026-03919-5.

Versions

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Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 7 authors, 3 keywords, 14 MeSH terms, 3 funders, 42 references.

Cite

This paper

Huggett, S. B., Selveraj, S., McGeary, J. E., Ikeda, A. S., Yuan, E., Loeffel, L. B., & Palmer, R. H. C. (2026). Bulk and single-cell transcriptomic brain data identify overlapping processes and cell-types with human AUD and mammalian models of alcohol use. Translational psychiatry, 16(1), 212. https://doi.org/10.1038/s41398-026-03919-5

BibTeX

@article{huggett2026bulk,
author = {Huggett, Spencer B and Selveraj, Sharmila and McGeary, John E and Ikeda, Ami S and Yuan, Emerald and Loeffel, Lauren B and Palmer, Rohan H C},
title = {{Bulk and single-cell transcriptomic brain data identify overlapping processes and cell-types with human AUD and mammalian models of alcohol use}},
journal = {Translational psychiatry},
year = {2026},
month = mar,
volume = {16},
number = {1},
pages = {212},
publisher = {Nature Publishing Group},
issn = {2158-3188},
doi = {10.1038/s41398-026-03919-5},
url = {https://doi.org/10.1038/s41398-026-03919-5},
pmid = {41896532},
pmcid = {PMC13039797}
}

RIS

TY - JOUR
AU - Huggett, Spencer B
AU - Selveraj, Sharmila
AU - McGeary, John E
AU - Ikeda, Ami S
AU - Yuan, Emerald
AU - Loeffel, Lauren B
AU - Palmer, Rohan H C
TI - Bulk and single-cell transcriptomic brain data identify overlapping processes and cell-types with human AUD and mammalian models of alcohol use
T2 - Translational psychiatry
J2 - Transl Psychiatry
PY - 2026
DA - 2026/03/27
VL - 16
IS - 1
SP - 212
SN - 2158-3188
PB - Nature Publishing Group
DO - 10.1038/s41398-026-03919-5
UR - https://doi.org/10.1038/s41398-026-03919-5
LA - en
ER -

CSL-JSON

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"container-title": "Translational psychiatry",
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"language": "en",
"issued": {
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