mmu_circ_0012122/mmu-miR-1843-5p/Sertad2 axis: A novel regulatory pathway in rabies virus infection.

Overview

1. Lab of Veterinary Pharmaceutics, Institute of Animal Health, Guangdong Academy of Agricultural Sciences, Guangdong Province Key Laboratory of Livestock Disease Prevention, Guangzhou, P. R. China
2. Lab of Parasitology, Institute of Animal Health, Guangdong Academy of Agricultural Sciences, Guangdong Province Key Laboratory of Livestock Disease Prevention, Guangzhou, P. R. China
3. Zoonotic & Livestock Diseases (Cattle/Sheep) Research Lab, Institute of Animal Health, Guangdong Academy of Agricultural Sciences, Guangdong Province Key Laboratory of Livestock Disease Prevention, Guangzhou, P. R. China

Abstract

Rabies virus (RABV) causes severe central nervous system damage, though the underlying mechanisms remain unclear. Circular RNAs (circRNAs) have been identified in various cells and tissues and are known to regulate gene expression in eukaryotes. Here, we investigated the expression patterns of circRNAs in brain tissues from mice infected with two strains of RABV (CVS-11 and SRV9) and compared them to brain tissues from uninfected mice. Differential expression analysis identified 1,306 circRNAs, primarily derived from coding exons, with functional enrichment implicating synaptic and nervous system pathways. Critically, we identified and validated a novel regulatory axis, mmu_circ_0012122/mmu-miR-1843-5p/Sertad2, where mmu_circ_0012122 acts as a sponge for mmu-miR-1843-5p, leading to Sertad2 upregulation. This axis differentially modulated murine nerve cell fate: mmu_circ_0012122 knockdown reduced necrotic and non-viable apoptotic cells, while mmu-miR-1843-5p overexpression suppressed viable apoptosis and necrosis. Comprehensive characterization further identified Sertad2 as a key mediator promoting both nerve cell apoptosis and neuroinflammatory responses during infection. These findings underscored circRNAs as critical regulators of neuronal survival during RABV infection and highlighted the mmu_circ_0012122-driven network as a potential therapeutic target.

Reproduced under the paper's license (CC BY), from the paper cited above.

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Data

Datasets cited

• bioproject:PRJNA1053907, at NCBI BioProject; found in “Data availability statement”
• figshare:29939639, at figshare; found in “Data availability statement”
• figshare:32719861, at figshare; found in DataCite

Data availability statement

The raw RNA sequencing data that support the findings of this study are openly available in National Center for Biotechnology Information (NCBI), at https://www.ncbi.nlm.nih.gov/sra/?term=PRJNA105390742, and the raw experimental data are openly available in Figshare database at https://doi.org/10.6084/m9.figshare.29939639 [49].

Reproduced under the paper's license (CC BY), from the paper cited above.

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 9 authors, 4 keywords, 9 MeSH terms, 3 funders, 48 references.

Cite

This paper

Ye, Q., Tang, X., Cai, H., Yuan, M., Ba, X., Tian, Y., Chen, J., Wang, X., & Xiang, R. (2026). mmu_circ_0012122/mmu-miR-1843-5p/Sertad2 axis: A novel regulatory pathway in rabies virus infection. Virulence, 17(1), 2690777. https://doi.org/10.1080/21505594.2026.2690777

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