Peri-Microvascular Glycogen and Lactate Regulate Capillary Constrictions and Ischemia Outcome in Mice.
Overview
- Institute of Neurological Sciences and Psychiatry Hacettepe University Ankara Turkey
- Institut Químic de Sarrià (IQS) Universitat Ramon Llull (URL) Barcelona Spain
- Institute for Research in Biomedicine (IRB Barcelona) Barcelona Spain
- Oral and Maxillofacial Anatomy Tokushima University Graduate School Tokushima Japan
- Department of Neurology, Faculty of Medicine Hacettepe University Ankara Turkey
Abstract
Ischemic stroke results in sudden blood flow cessation, thus unmet energy requirements. Glycogen stored around peri‐microvascular astrocyte end‐feet may mediate capillary contractility and cerebral blood flow alterations. Under glucose‐deprived and hypoxic conditions, lactate derived from these glycogen stores may serve as an emergency fuel to sustain tissue perfusion during an acute period of ischemic stroke. To elucidate the impact of glycogen utilization on brain microcirculation, both 1,4‐dideoxy‐1,4‐imino‐d‐
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
The paper says that its authors' code is available on request: it was not published with the paper, so there is nothing to verify.
The paper's code and data availability statement is in the Data section.
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Data
No dataset and no data link were found in the paper.
Data Availability Statement
All aggregated data supporting the findings of this study are included in the main text, figures, or supporting information. Primary data (including images and spreadsheets) are available from the corresponding author upon reasonable written request. This study does not report any original code. Additional information related to this work is available from the corresponding author upon request.
Reproduced under the paper's license (CC BY), from the paper cited above.
Data and Code Availability
All summarized data are in the main text, figures, or supporting information. Primary data (e.g., images, spreadsheets) and the original MATLAB code for spatiotemporal regional cerebral blood flow (rCBF) measurements via pseudo‐colored maps are available upon request from the lead contact. Preprint of this manuscript was uploaded on bioRxiv; August 26, 2022; https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 2, 28 September 2026
- Publisher: n/a → Wiley
Version 1, 28 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 13 authors, 5 keywords, 16 MeSH terms, 1 funder, 61 references, 18 RRIDs.
Cite
This paper
Uruk, G., Donmez‐Demir, B., Yilmaz‐Ozcan, S., Cakir‐Aktas, C., Taskiran‐Sag, A., Gurler, G., Duran, J., Guinovart, J. J., Baba, O., Morita, T., Karatas, H., Dalkara, T., & Yemisci, M. (2026). Peri-Microvascular Glycogen and Lactate Regulate Capillary Constrictions and Ischemia Outcome in Mice. Journal of neurochemistry, 170(4), e70430. https://
BibTeX
@article{uruk2026peri,
author = {Uruk, Gokhan and Donmez‐Demir, Buket and Yilmaz‐Ozcan, Sinem and Cakir‐Aktas, Canan and Taskiran‐Sag, Aslihan and Gurler, Gokce and Duran, Jordi and Guinovart, Joan J. and Baba, Otto and Morita, Tsuyoshi and Karatas, Hulya and Dalkara, Turgay and Yemisci, Muge},
title = {{Peri-Microvascular Glycogen and Lactate Regulate Capillary Constrictions and Ischemia Outcome in Mice}},
journal = {Journal of neurochemistry},
year = {2026},
month = apr,
volume = {170},
number = {4},
pages = {e70430},
publisher = {Wiley},
issn = {0022-3042},
doi = {10.1111/
url = {https://
pmid = {41989058},
pmcid = {PMC13085847}
}
RIS
TY - JOUR
AU - Uruk, Gokhan
AU - Donmez‐Demir, Buket
AU - Yilmaz‐Ozcan, Sinem
AU - Cakir‐Aktas, Canan
AU - Taskiran‐Sag, Aslihan
AU - Gurler, Gokce
AU - Duran, Jordi
AU - Guinovart, Joan J.
AU - Baba, Otto
AU - Morita, Tsuyoshi
AU - Karatas, Hulya
AU - Dalkara, Turgay
AU - Yemisci, Muge
TI - Peri-Microvascular Glycogen and Lactate Regulate Capillary Constrictions and Ischemia Outcome in Mice
T2 - Journal of neurochemistry
J2 - J Neurochem
PY - 2026
DA - 2026/
VL - 170
IS - 4
SP - e70430
SN - 0022-3042
PB - Wiley
DO - 10.1111/
UR - https://
LA - en
ER -
CSL-JSON
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