Alk-Fam150b (augmentor α) expression in the paraventricular nucleus of the mouse hypothalamus at molecular resolution, and its sensitivity to acute stress.
Overview
- Department of Neuroscience, Biomedicum 7D, Karolinska Institutet, Solna, Sweden
- Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Vienna, Austria
Abstract
Augmentor α (Fam150b)‐induced activation of the ALK receptor (Alk) has gained significance as a hypothalamic signaling pathway with relevance to the control of food intake and energy homeostasis. In contrast, much less is known about the sensitivity of Fam150b‐Alk expression and signaling upon noxious challenges. In this regard, acute stress is of particular interest because augmentor α, released from afferents of the food intake circuit of the arcuate nucleus within the paraventricular hypothalamus (PVN), could link stress‐induced changes in food consumption. Nevertheless, conflicting data exist on whether Fam150b mRNA is expressed in the PVN. Here, we combined single‐cell RNA‐seq and multiplexed in situ hybridization to demonstrate that both Fam150b and Alk are expressed in the PVN of adult mice, including corticotropin‐releasing hormone (CRH)‐containing neurons. As such, a dichotomy of CRH neurons is present through their mutually exclusive expression of either Fam150b or Scgn (secretagogin). Fam150b and Alk were not co‐expressed. When inducing inflammation‐associated stress, Fam150b but not Alk mRNA expression increased in a mifepristone‐sensitive manner, implying regulation by peripheral glucocorticoid feedback. We suggest that augmentor α‐ALK signaling could underpin, at least partly, stress‐induced changes in feeding and the control of body weight.
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
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harkany-lab.github.io/gueissaz_2025
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Reproduced under the paper's license (CC BY), from the paper cited above.
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Data availability statement
The data that support the findings of this study are available from the corresponding author upon reasonable request.
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Version 1, 30 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 5 authors, 4 keywords, 9 MeSH terms, 5 funders, 66 references.
Cite
This paper
Gueissaz, L., Sideromenos, S., Tretiakov, E. O., Schnell, R., & Harkany, T. (2026). Alk-Fam150b (augmentor α) expression in the paraventricular nucleus of the mouse hypothalamus at molecular resolution, and its sensitivity to acute stress. Journal of neuroendocrinology, 38(3), e70159. https://
BibTeX
@article{gueissaz2026alk
author = {Gueissaz, Laurent and Sideromenos, Spyridon and Tretiakov, Evgenii O and Schnell, Robert and Harkany, Tibor},
title = {{Alk-Fam150b (augmentor α) expression in the paraventricular nucleus of the mouse hypothalamus at molecular resolution, and its sensitivity to acute stress}},
journal = {Journal of neuroendocrinology},
year = {2026},
month = mar,
volume = {38},
number = {3},
pages = {e70159},
publisher = {Wiley},
issn = {0953-8194},
doi = {10.1111/
url = {https://
pmid = {41856795},
pmcid = {PMC13002349}
}
RIS
TY - JOUR
AU - Gueissaz, Laurent
AU - Sideromenos, Spyridon
AU - Tretiakov, Evgenii O
AU - Schnell, Robert
AU - Harkany, Tibor
TI - Alk-Fam150b (augmentor α) expression in the paraventricular nucleus of the mouse hypothalamus at molecular resolution, and its sensitivity to acute stress
T2 - Journal of neuroendocrinology
J2 - J Neuroendocrinol
PY - 2026
DA - 2026/
VL - 38
IS - 3
SP - e70159
SN - 0953-8194
PB - Wiley
DO - 10.1111/
UR - https://
LA - en
ER -
CSL-JSON
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