Aerobic exercise significantly alters <i>Notch1</i> signaling in a neurotoxic hippocampal rat model of Alzheimer's disease.
Overview
- Department of Exercise Physiology, Faculty of Physical Education and Sport Science, University of Mazandaran, Babolsar, Iran
- Motor Behavior, University of Mazandaran, Mazandaran, Iran
- Department of Sports Sciences, Faculty of Humanities, University of Maragheh, Maragheh, Iran
- School of Nursing, University of Texas Medical Branch at Galveston, Galveston, TX, USA
Abstract
Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder and a major cause of dementia.
Objective: The aim of this study was to investigate the effect of aerobic training on the expression changes of Notch1, Rbpjk, Hes1, and Hey1genes in the hippocampus of Alzheimer rats.
Methods: Forty, 8-week-old male Wistar rats were divided into four groups: control (n = 10), exercise (n = 10), AD (n = 10), AD + exercise (n = 10). Endurance training was implemented with increasing intensity starting at 15 m/
Results: One-way analysis of variance with Tukey's post-hoc analysis found that the Alz group had significantly lower expression of Notch1 with increased expression of Rbpjk and Hes1. Conversely, the AD + Ex group was observed to have significantly higher Notch1 and significantly lower Rbpjk compared to the AD group.
Conclusions: These findings suggest that exercise may serve as a complementary neuroprotective intervention via manipulation of Notch1 signaling. Overall, the study highlights the need for further research on the relationship between physical activity and gene expression in the context of AD.
Reproduced under the paper's license (CC BY), from the paper cited above.
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- figshare:29922488, at figshare; found in the end of the paper
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Version 1, 30 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 8 authors, 6 keywords, 14 MeSH terms, 36 references.
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This paper
Tavan, Y., Roozegar, S., Mohammadi, Z. F., Akbari, A., Nasiri, K., Memarmoghaddam, M., Talebi, V., & Patel, D. I. (2026). Aerobic exercise significantly alters &
BibTeX
@article{tavan2026aerobi
author = {Tavan, Yosra and Roozegar, Somayyeh and Mohammadi, Ziya Fallah and Akbari, Abolfazl and Nasiri, Khadijeh and Memarmoghaddam, Mozhgan and Talebi, Vahid and Patel, Darpan I.},
title = {{Aerobic exercise significantly alters \&
journal = {Journal of Alzheimer's disease : JAD},
year = {2026},
month = mar,
volume = {111},
number = {2},
pages = {545--552},
publisher = {IOS Press},
issn = {1387-2877},
doi = {10.1177/
url = {https://
pmid = {41879277},
pmcid = {PMC13161492}
}
RIS
TY - JOUR
AU - Tavan, Yosra
AU - Roozegar, Somayyeh
AU - Mohammadi, Ziya Fallah
AU - Akbari, Abolfazl
AU - Nasiri, Khadijeh
AU - Memarmoghaddam, Mozhgan
AU - Talebi, Vahid
AU - Patel, Darpan I.
TI - Aerobic exercise significantly alters &
T2 - Journal of Alzheimer's disease : JAD
J2 - J Alzheimers Dis
PY - 2026
DA - 2026/
VL - 111
IS - 2
SP - 545
EP - 552
SN - 1387-2877
PB - IOS Press
DO - 10.1177/
UR - https://
LA - en
ER -
CSL-JSON
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"URL": "https://
"language": "en",
"issued": {
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