Transcriptomic profile of the hippocampus of rat strains with contrasting nervous system excitability.
Overview
Abstract
Individual variability of reactions to environmental influences which determines the range of the “reaction norm” and the possibilities of adaptation is strongly shaped by inherited properties of the nervous system, including genetically determined differences in excitability. Rat strains selectively bred for contrasting thresholds of neural system excitability provide a model for studying how such inherited differences are reflected at the molecular level. Here, we performed bulk RNA sequencing of the hippocampus in high-excitability (LT) and low-excitability (HT) rats to characterize baseline interstrain transcriptomic divergence. Differential expression analysis revealed strain-specific transcriptional profiles involving not only synapse- and plasticity-related genes, but also non-neuronal components associated with glial/
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
The paper links to its data, not to its authors' code: see the Data section.
Tracing map
A tracing map links a paper to the code its authors published: this paper has none, so it has no map.
Data
Datasets cited
- geo:GSE327807, at NCBI GEO; found in the text, “RNA sequencing analyses”
Data Availability
All relevant data are within the manuscript and its Supporting information files. The raw and processed data in NCBI - GSE327807.
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 2, 28 September 2026
- Funding: added Siberian Branch, Russian Academy of Sciences; Directorate for Biological Sciences; Russian Academy of Sciences: 1021062411629-7-3.1.4
Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 3 authors, 7 MeSH terms, 78 references.
Cite
This paper
Pavlova, M., Shalaginova, I., & Dyuzhikova, N. (2026). Transcriptomic profile of the hippocampus of rat strains with contrasting nervous system excitability. PloS one, 21(6), e0350674. https://
BibTeX
@article{pavlova2026tran
author = {Pavlova, Marina and Shalaginova, Irina and Dyuzhikova, Natalia},
title = {{Transcriptomic profile of the hippocampus of rat strains with contrasting nervous system excitability}},
journal = {PloS one},
year = {2026},
month = jun,
volume = {21},
number = {6},
pages = {e0350674},
publisher = {PLOS},
issn = {1932-6203},
doi = {10.1371/
url = {https://
pmid = {42234683},
pmcid = {PMC13232848}
}
RIS
TY - JOUR
AU - Pavlova, Marina
AU - Shalaginova, Irina
AU - Dyuzhikova, Natalia
TI - Transcriptomic profile of the hippocampus of rat strains with contrasting nervous system excitability
T2 - PloS one
J2 - PLoS One
PY - 2026
DA - 2026/
VL - 21
IS - 6
SP - e0350674
SN - 1932-6203
PB - PLOS
DO - 10.1371/
UR - https://
LA - en
ER -
CSL-JSON
{
"id": "10.1371/
"type": "article-journal",
"title": "Transcriptomic profile of the hippocampus of rat strains with contrasting nervous system excitability",
"container-title": "PloS one",
"author": [
{
"family": "Pavlova",
"given": "Marina"
},
{
"family": "Shalaginova",
"given": "Irina"
},
{
"family": "Dyuzhikova",
"given": "Natalia"
}
],
"container-title-short":
"volume": "21",
"issue": "6",
"page": "e0350674",
"DOI": "10.1371/
"PMID": "42234683",
"PMCID": "PMC13232848",
"ISSN": "1932-6203",
"publisher": "PLOS",
"URL": "https://
"language": "en",
"issued": {
"date-parts": [
[
2026,
6,
3
]
]
}
}
Similar papers
The papers with a page that share the most with this one: the tools found in their code, their categories, datasets, cited references and authors, the rarest counting most.
- [1] doi:10.1186/s12864-026-13028-8
- Selective hippocampal transcriptional adaptation to long-term cannabidiol exposure in mice.Journal: BMC genomicsIn common: genetics / omics, cellular / molecular, 3 references
- [2] doi:10.26508/lsa.202503551 [code]
- Convergent transcriptomic signature in iPSC-dopaminergic neurons of hereditary Parkinson's disease.Journal: Life science allianceIn common: genetics / omics, cellular / molecular, 3 references
- [3] doi:10.1038/s41467-026-71360-9 [code]
- Perinatal brain developmental transition revealed by transcriptomic and proteomic analyses of Bama miniature pigs.Journal: Nature communicationsIn common: genetics / omics, 3 references
- [4] doi:10.1126/sciadv.adt2527
- NPAS3-regulated astrocyte mitochondrial bioenergetics is required for cognition.Journal: Science advancesIn common: cellular / molecular, 3 references
- [5] doi:10.1038/s44319-026-00786-5
- Age-related decline in nuclear envelope LINC complex drives neuronal aging via axon initial segment dysfunction.Journal: EMBO reportsIn common: cellular / molecular, 3 references
- [6] doi:10.1186/s13041-026-01298-y
- Repeated sleep deprivation selectively reactivates hippocampal CA1 pyramidal neurons.Journal: Molecular brainIn common: cellular / molecular, 3 references
- [7] doi:10.1038/s41598-026-51581-0 [code]
- TLR7-induced murine inflammation results in a global neuroinflammatory response driving neural circuit-specific transcriptomic changes.Journal: Scientific reportsIn common: genetics / omics, cellular / molecular, 2 references
- [8] doi:10.1523/jneurosci.0409-25.2026
- The Role of Disulfide Bonds in the GluN1 Subunit in the Early Trafficking and Functional Properties of GluN1/
GluN2 and GluN1/ GluN3 NMDA Receptors. Journal: The Journal of neuroscience : the official journal of the Society for NeuroscienceIn common: rat, genetics / omics, cellular / molecular, 1 reference - [9] doi:10.1038/s41467-026-73796-5 [code]
- Cross-species transcriptomic analysis of rodent model fidelity to human mesial temporal lobe epilepsy.Journal: Nature communicationsIn common: rat, genetics / omics, cellular / molecular, 2 references
- [10] doi:10.7717/peerj.21426 [code]
- Integrated transcriptomic identification and validation reveal key autophagy-associated biomarkers in sleep deprivation.Journal: PeerJIn common: rat, genetics / omics, cellular / molecular, 1 reference
Contribute
The authors of this paper can claim it, correct its record and validate its tracing map, and the maintainers of its code (its owner, or a public member of its organization) correct what it says of their repository; anyone signed in can ask for its removal. Every request goes to OSCR's own machine, which answers it; your account page follows them.
Sign in with ORCID to claim this paper as one of its authors, correct its record or validate its tracing map: when the paper's metadata lists your ORCID iD, you are recognized at once. Maintainers of its code: sign in with GitHub, then claim the repository on your account page.
Claim this paper
Correct its record
Say what each link of this record is, remove the ones that are not the paper's, add the ones that are missing. The correction becomes a new version of the record, in its Versions section.
Request its removal
To ask OSCR to remove this record, the copies of its authors' scripts or its tracing map, use the removal request page: signed in, you say who you are, what to remove and why, then review and confirm the request. Published rules decide every request (how).
Discussion, reproductions, activity
Discussion: questions and error reports about this paper and its code, from signed-in readers and its authors. It opens with sign-in.
Reproductions: reports from readers who ran the authors' code: what they reproduced, with which environment, commit and data. It opens with sign-in.
Activity: what happens around this paper: new versions of its record, its map's validation, discussions and reproductions. It opens with sign-in.