IncRNAs transcriptomics elucidates the potential mechanism of Naoshuantong capsule in alleviating synaptic dysfunction in a murine model of cerebral ischemia/reperfusion injury.
Overview
- Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China
- Institute for Brain Disorders, Beijing University of Chinese Medicine, Beijing, China
- Integrated Traditional and Western Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
- Department of Neurology, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China
Abstract
Background: Naoshuantong capsule (NST), a Traditional Chinese Medicine formulation, is used for ischemic stroke treatment; however, its molecular mechanisms are unclear. This study aimed to investigate the mechanistic basis of NST using long noncoding RNA (lncRNA) and messenger RNA (mRNA) transcriptomics.
Methods: The metabolites of NST were analyzed. Additionally, its systemically absorbed metabolites (in plasma) and brain-distributed metabolites were identified using ultrahigh-performance liquid chromatography–tandem mass spectrometry (UHPLC-MS/
Results: UHPLC-MS/
Conclusion: NST may protect against cerebral ischemia/
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data
Datasets cited
- figshare:31302553, at figshare; found in “Data availability statement”
Data availability statement
The original contributions presented in the study are publicly available. This data can be found here: https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 1, 30 September 2026: the first record
Recorded: type, language, journal, volume, pages, dates, 11 authors, 5 keywords, 4 funders, 52 references.
Cite
This paper
Song, K., Zhang, H., Liu, H., Li, Y., Sun, Y., Dong, X., Tao, C., He, Y., Liu, Z., Gao, Y., & Gao, Y. (2026). IncRNAs transcriptomics elucidates the potential mechanism of Naoshuantong capsule in alleviating synaptic dysfunction in a murine model of cerebral ischemia/
BibTeX
@article{song2026incrnas
author = {Song, Ke and Zhang, Hongrui and Liu, Haoqi and Li, Yuanyuan and Sun, Yikun and Dong, Xinglu and Tao, Chenxi and He, Yannan and Liu, Zhenhong and Gao, Yonghong and Gao, Ying},
title = {{IncRNAs transcriptomics elucidates the potential mechanism of Naoshuantong capsule in alleviating synaptic dysfunction in a murine model of cerebral ischemia/
journal = {Frontiers in pharmacology},
year = {2026},
month = mar,
volume = {17},
pages = {1722930},
publisher = {Frontiers Media SA},
issn = {1663-9812},
doi = {10.3389/
url = {https://
pmid = {41868129},
pmcid = {PMC12999579}
}
RIS
TY - JOUR
AU - Song, Ke
AU - Zhang, Hongrui
AU - Liu, Haoqi
AU - Li, Yuanyuan
AU - Sun, Yikun
AU - Dong, Xinglu
AU - Tao, Chenxi
AU - He, Yannan
AU - Liu, Zhenhong
AU - Gao, Yonghong
AU - Gao, Ying
TI - IncRNAs transcriptomics elucidates the potential mechanism of Naoshuantong capsule in alleviating synaptic dysfunction in a murine model of cerebral ischemia/
T2 - Frontiers in pharmacology
J2 - Front Pharmacol
PY - 2026
DA - 2026/
VL - 17
SP - 1722930
SN - 1663-9812
PB - Frontiers Media SA
DO - 10.3389/
UR - https://
LA - en
ER -
CSL-JSON
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