OSCR

Plasma GFAP and language-network tau mediate the effect of amyloid burden on semantic fluency: A mediation analysis.

Overview

Authors: Wei Han1,2, Na Li3, Peishen Wang3, Wenhao An4, Xinye Han3, Yihua An3,4, for the Alzheimer's Disease Neuroimaging Initiative
ORCID iDs: Yihua An
  1. Department of Evidence‐Based Medicine Xuanwu Hospital Capital Medical University Beijing China
  2. Beijing Municipal Geriatric Medical Research Center Beijing Geriatric Healthcare Center Beijing China
  3. Beijing Yihua Biotechnology Co., Ltd Beijing China
  4. Department of Neurosurgery Sanbo Brain Hospital Capital Medical University Beijing China
Institutions: Capital Medical University (China); Beijing Geriatric Hospital (China); Xuan Wu Hospital of the Capital Medical University (China); Beijing Sanbo Brain Hospital (China)
Journal: Alzheimer's & dementia (Amsterdam, Netherlands), volume 18, issue 3, article e70475
Dates: received 28 April 2026; accepted 6 August 2026; published online 8 September 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1002/dad2.70475 · PMID 42719511 · PMCID PMC13554988 · OpenAlex W7212021674
Open access: gold, a free copy (OpenAlex)
Status: code on request
Categories: other (modality), PET / SPECT (modality), human (organism), Alzheimer's / dementia (population), cellular / molecular (subfield)
Methods: Statistics
Keywords: Alzheimer's disease, amyloid positron emission tomography (PET), tau PET, causal mediation analysis, plasma glial fibrillary acidic protein, semantic fluency
Topic: Dementia and Cognitive Impairment Research (Psychiatry and Mental health, Medicine), according to OpenAlex
Funding: National Institute on Aging, the National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Alzheimer's Disease Neuroimaging Initiative (ADNI) (U19AG024904); DOD ADNI (W81XWH‐12‐2‐0012)
Citations: not cited yet (Europe PMC); 38 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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The paper's code and data availability statement is in the Data section.

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Data

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Code and data availability statement

The paper has a code and data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

  • it says that the code is available on request

Read it in the paper: doi.org/10.1002/dad2.70475.

Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 7 authors, 6 keywords, 4 funders, 38 references.

Cite

This paper

Han, W., Li, N., Wang, P., An, W., Han, X., An, Y., & for the Alzheimer's Disease Neuroimaging Initiative. (2026). Plasma GFAP and language-network tau mediate the effect of amyloid burden on semantic fluency: A mediation analysis. Alzheimer's & dementia (Amsterdam, Netherlands), 18(3), e70475. https://doi.org/10.1002/dad2.70475

BibTeX

@article{han2026plasma,
author = {Han, Wei and Li, Na and Wang, Peishen and An, Wenhao and Han, Xinye and An, Yihua and {for the Alzheimer's Disease Neuroimaging Initiative}},
title = {{Plasma GFAP and language-network tau mediate the effect of amyloid burden on semantic fluency: A mediation analysis}},
journal = {Alzheimer's \& dementia (Amsterdam, Netherlands)},
year = {2026},
month = jul,
volume = {18},
number = {3},
pages = {e70475},
publisher = {Wiley},
issn = {2352-8729},
doi = {10.1002/dad2.70475},
url = {https://doi.org/10.1002/dad2.70475},
pmid = {42719511},
pmcid = {PMC13554988}
}

RIS

TY - JOUR
AU - Han, Wei
AU - Li, Na
AU - Wang, Peishen
AU - An, Wenhao
AU - Han, Xinye
AU - An, Yihua
AU - for the Alzheimer's Disease Neuroimaging Initiative
TI - Plasma GFAP and language-network tau mediate the effect of amyloid burden on semantic fluency: A mediation analysis
T2 - Alzheimer's & dementia (Amsterdam, Netherlands)
J2 - Alzheimers Dement (Amst)
PY - 2026
DA - 2026/07/01
VL - 18
IS - 3
SP - e70475
SN - 2352-8729
PB - Wiley
DO - 10.1002/dad2.70475
UR - https://doi.org/10.1002/dad2.70475
LA - en
ER -

CSL-JSON

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"author": [
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"container-title-short": "Alzheimers Dement (Amst)",
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"language": "en",
"issued": {
"date-parts": [
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}

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