OSCR

Sympathetic nervous system-mediated fibro-adipogenic progenitor mobilization drives stroke-related sarcopenia.

Overview

Authors: Yinong Huang1,2,3, Yilin Liu2,3,4, Ruijie Li2,3, Mingming Fan2,3,5, Yixuan Liu2,3, Yiling Wang2,3, Xin Sui5, Xiaofeng Yuan6, Qiying Lu2,3,7, Yuan Qiu2,3, Ruijun Li2,3, Jierui Chen2,3, Bingjun Zhang8, Sanxin Liu8, Chuyun Ou8, Yuanchen Ma2,3,9, Xiaofan Lai10, Jie Ren11, Zhengqi Lu8, Huimin Yi5, Weijun Huang2,3, Jiancheng Wang12, Yanbing Li1, Haipeng Xiao1, Andy Peng Xiang2,3,13
ORCID iDs: Jiancheng Wang, Haipeng Xiao, Andy Peng Xiang
13 affiliations
  1. Department of Endocrinology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong China
  2. Center for Stem Cell Biology and Tissue Engineering, Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou, Guangdong China
  3. National-Local Joint Engineering Research Center for Stem Cells and Regenerative Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong China
  4. Department of Critical Care Medicine, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong China
  5. Department of Surgery Intensive Care Unit, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong China
  6. Department of General Intensive Care Unit, Lingnan Hospital, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong China
  7. Department of Rehabilitation Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong China
  8. Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong China
  9. Department of Gastrointestinal Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong China
  10. Department of Anesthesiology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong China
  11. Department of Medical Ultrasonics, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou Guangdong, China
  12. Scientific Research Center, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong China
  13. Department of Histoembryology and Cell Biology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong China
Institutions: Sun Yat-sen University (China); The First Affiliated Hospital, Sun Yat-sen University (China); Third Affiliated Hospital of Sun Yat-sen University (China); The Seventh Affiliated Hospital of Sun Yat-sen University (China)
Journal: Cell discovery, volume 12, issue 1, article 49
Dates: received 10 June 2025; accepted 23 April 2026; published online 7 July 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.1038/s41421-026-00899-0 · PMID 42409779 · PMCID PMC13338466 · OpenAlex W7167458647
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: stroke (population), cellular / molecular (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, fMRI & imaging
Keywords: Mesenchymal stem cells, Mechanisms of disease
Topic: Muscle Physiology and Disorders (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: National Natural Science Foundation of China (National Science Foundation of China) (82101367)
Citations: not cited yet (Europe PMC); 83 references in the paper

Abstract

Patients who survive stroke usually experience rapid muscle wasting and an increased risk of physical disability. Although multifactorial interactions, including malnutrition, disuse, systemic catabolic imbalance, and neurohormonal dysregulation, are thought to contribute to the progression of stroke-related sarcopenia, the underlying mechanisms of this brain–muscle crosstalk remain elusive. Muscle-resident fibro-adipogenic progenitors (FAPs) are indispensable for maintaining muscle homeostasis and function as initial sensors of external perturbations. In the present study, we report that FAPs rapidly respond to the overactive sympathetic nervous system (SNS) and egress from the muscle niche into circulation during the acute phase of stroke. FAP-specific ablation of adrenoceptor beta 2 (Adrb2) markedly ameliorated stroke-related sarcopenia, highlighting the central role of SNS-mediated FAP loss in its pathogenesis. Mechanistically, increased norepinephrine release initiates FAP mobilization through the activation of pro-migratory signals and the degradation of extracellular matrix components. Using transcriptomic profiling, we further characterized insulin growth factor-1 (IGF-1) as a key anti-atrophic executive factor predominantly derived from FAPs. Collectively, our work demonstrates that the SNS-mediated loss of FAPs and subsequent compromised IGF-1 secretion contribute to sarcopenia in mice following stroke. Targeting this mechanism by early anti-sympathetic treatment with propranolol may effectively restore muscle homeostasis and mass after stroke.

Reproduced under the paper's license (CC BY), from the paper cited above.

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Data

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Versions

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Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 25 authors, 2 keywords, 1 funder, 83 references.

Cite

This paper

Huang, Y., Liu, Y., Li, R., Fan, M., Liu, Y., Wang, Y., Sui, X., Yuan, X., Lu, Q., Qiu, Y., Li, R., Chen, J., Zhang, B., Liu, S., Ou, C., Ma, Y., Lai, X., Ren, J., Lu, Z., . . . Xiang, A. P. (2026). Sympathetic nervous system-mediated fibro-adipogenic progenitor mobilization drives stroke-related sarcopenia. Cell discovery, 12(1), 49. https://doi.org/10.1038/s41421-026-00899-0

BibTeX

@article{huang2026sympathetic,
author = {Huang, Yinong and Liu, Yilin and Li, Ruijie and Fan, Mingming and Liu, Yixuan and Wang, Yiling and Sui, Xin and Yuan, Xiaofeng and Lu, Qiying and Qiu, Yuan and Li, Ruijun and Chen, Jierui and Zhang, Bingjun and Liu, Sanxin and Ou, Chuyun and Ma, Yuanchen and Lai, Xiaofan and Ren, Jie and Lu, Zhengqi and Yi, Huimin and Huang, Weijun and Wang, Jiancheng and Li, Yanbing and Xiao, Haipeng and Xiang, Andy Peng},
title = {{Sympathetic nervous system-mediated fibro-adipogenic progenitor mobilization drives stroke-related sarcopenia}},
journal = {Cell discovery},
year = {2026},
month = jul,
volume = {12},
number = {1},
pages = {49},
publisher = {Nature Publishing Group},
issn = {2056-5968},
doi = {10.1038/s41421-026-00899-0},
url = {https://doi.org/10.1038/s41421-026-00899-0},
pmid = {42409779},
pmcid = {PMC13338466}
}

RIS

TY - JOUR
AU - Huang, Yinong
AU - Liu, Yilin
AU - Li, Ruijie
AU - Fan, Mingming
AU - Liu, Yixuan
AU - Wang, Yiling
AU - Sui, Xin
AU - Yuan, Xiaofeng
AU - Lu, Qiying
AU - Qiu, Yuan
AU - Li, Ruijun
AU - Chen, Jierui
AU - Zhang, Bingjun
AU - Liu, Sanxin
AU - Ou, Chuyun
AU - Ma, Yuanchen
AU - Lai, Xiaofan
AU - Ren, Jie
AU - Lu, Zhengqi
AU - Yi, Huimin
AU - Huang, Weijun
AU - Wang, Jiancheng
AU - Li, Yanbing
AU - Xiao, Haipeng
AU - Xiang, Andy Peng
TI - Sympathetic nervous system-mediated fibro-adipogenic progenitor mobilization drives stroke-related sarcopenia
T2 - Cell discovery
J2 - Cell Discov
PY - 2026
DA - 2026/07/07
VL - 12
IS - 1
SP - 49
SN - 2056-5968
PB - Nature Publishing Group
DO - 10.1038/s41421-026-00899-0
UR - https://doi.org/10.1038/s41421-026-00899-0
LA - en
ER -

CSL-JSON

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