OSCR

Distinct Filament Conformation for Receptor-Bound Amyloid-β from Alzheimer's Disease Brain.

Overview

Authors: Mikhail A Kostylev1, Carmen Butan1, Graham P Roseman1, Yangyi Liu1, Tanina Arab1, Ruibing Wu1, Pallavi Gopal2, Stephen M Strittmatter1,3
ORCID iDs: Ruibing Wu, Pallavi Gopal, Stephen M Strittmatter
  1. Departments of Neuroscience, Yale School of Medicine, New Haven, CT USA
  2. Department of Pathology, Yale School of Medicine, New Haven, CT USA
  3. Department of Neurology, Yale School of Medicine, New Haven, CT USA
Institutions: Yale University (United States)
Journal: Nature communications, volume 17, issue 1, article 8953
Dates: received 21 November 2024; accepted 9 July 2026; published online 22 July 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41467-026-75895-9 · PMID 42637746 · PMCID PMC13503723 · OpenAlex W4415126098
Open access: gold, a free copy (OpenAlex)
Preprint: doi:10.1101/2025.10.10.681740
Status: data only
Categories: histology / microscopy (modality), human (organism), other condition (population), Alzheimer's / dementia (population), cellular / molecular (subfield)
Methods: fMRI & imaging
Keywords: Alzheimer's disease, Cryoelectron microscopy
MeSH: Alzheimer Disease*, Amyloid beta-Peptides*, Brain*, Animals, Cryoelectron Microscopy, Humans, Neurons, Plaque, Amyloid, Prions, Protein Binding, Protein Conformation, Synapses (* major topic)
Topic: Alzheimer's disease research and treatments (Physiology, Medicine), according to OpenAlex
Funding: U.S. Department of Health & Human Services | National Institutes of Health (P30AG066508, T32NS105583, R01AG034924); NIA NIH HHS (R01 AG034924, P30 AG066508); U.S. Department of Health & Human Services | National Institutes of Health (NIH) (T32NS105583, P30AG066508, R01AG034924); NINDS NIH HHS (T32 NS105583)
Citations: not cited yet (Europe PMC); 72 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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The paper's code and data availability statement is in the Data section.

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Data

Datasets cited

Code and data availability statement

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Read it in the paper: doi.org/10.1038/s41467-026-75895-9.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 8 authors, 2 keywords, 12 MeSH terms, 4 funders, 71 references.

Cite

This paper

Kostylev, M. A., Butan, C., Roseman, G. P., Liu, Y., Arab, T., Wu, R., Gopal, P., & Strittmatter, S. M. (2026). Distinct Filament Conformation for Receptor-Bound Amyloid-β from Alzheimer's Disease Brain. Nature communications, 17(1), 8953. https://doi.org/10.1038/s41467-026-75895-9

BibTeX

@article{kostylev2026distinct,
author = {Kostylev, Mikhail A and Butan, Carmen and Roseman, Graham P and Liu, Yangyi and Arab, Tanina and Wu, Ruibing and Gopal, Pallavi and Strittmatter, Stephen M},
title = {{Distinct Filament Conformation for Receptor-Bound Amyloid-β from Alzheimer's Disease Brain}},
journal = {Nature communications},
year = {2026},
month = jul,
volume = {17},
number = {1},
pages = {8953},
publisher = {Nature Publishing Group},
issn = {2041-1723},
doi = {10.1038/s41467-026-75895-9},
url = {https://doi.org/10.1038/s41467-026-75895-9},
pmid = {42637746},
pmcid = {PMC13503723}
}

RIS

TY - JOUR
AU - Kostylev, Mikhail A
AU - Butan, Carmen
AU - Roseman, Graham P
AU - Liu, Yangyi
AU - Arab, Tanina
AU - Wu, Ruibing
AU - Gopal, Pallavi
AU - Strittmatter, Stephen M
TI - Distinct Filament Conformation for Receptor-Bound Amyloid-β from Alzheimer's Disease Brain
T2 - Nature communications
J2 - Nat Commun
PY - 2026
DA - 2026/07/22
VL - 17
IS - 1
SP - 8953
SN - 2041-1723
PB - Nature Publishing Group
DO - 10.1038/s41467-026-75895-9
UR - https://doi.org/10.1038/s41467-026-75895-9
LA - en
ER -

CSL-JSON

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"language": "en",
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