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Characterizing the metabolomes of microglia, astrocytes and neurons in ageing and Alzheimer's brains.

A correction to this paper has been published: the notice, 42680904, from Europe PMC.

Overview

Authors: Jie Yu1,2,3, Fengzhi Li2,3,4, Xing-jun Chen2,3, Chenye Mou1,2, Di Yao2,3, Zhanying Bi2,3,5, Xiaoli Chen2,3,6,7,8, Lulu Du2, Ziyan Feng2, Xinshuang Zhang2, Xiaoqian Yu2, Lauren G Zacharias9, Ralph J DeBerardinis9,10,11, Li Zhang2,12, Zhen Li2, Benyan Luo1, Xiao-Ling Hu2,9,13, Woo-ping Ge2,3,8
ORCID iDs: Xing-jun Chen, Ralph J DeBerardinis, Li Zhang, Zhen Li, Benyan Luo, Xiao-Ling Hu, Woo-ping Ge
13 affiliations
  1. Department of Neurology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China
  2. Chinese Institute for Brain Research, Beijing (CIBR), Beijing, China
  3. Beijing Institute for Brain Research, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
  4. State Key Laboratory of Cognitive Neuroscience and Learning, Faculty of Psychology, Beijing Normal University, Beijing, China
  5. College of Life Sciences, Nankai University, Tianjin, China
  6. Institute of Biophysics, Chinese Academy of Sciences, Beijing, China
  7. School of Industry–Education Integration, University of Chinese Academy of Sciences, Beijing, China
  8. Changping Laboratory, Beijing, China
  9. Children’s Research Institute, University of Texas Southwestern Medical Center, Dallas, TX USA
  10. Eugene McDermott Center for Human Growth and Development, University of Texas Southwestern Medical School, Texas, TX USA
  11. Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX USA
  12. Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Chengdu, China
  13. School of Basic Medical Sciences, Capital Medical University, Beijing, China
Institutions: Chinese Academy of Medical Sciences & Peking Union Medical College (China); Chinese Institute for Brain Research (China); First Affiliated Hospital Zhejiang University (China); Zhejiang University (China); Beijing Normal University (China); State Key Laboratory of Cognitive Neuroscience and Learning; Chinese Academy of Sciences (China); Institute of Biophysics (China); University of Chinese Academy of Sciences (China); Changping Laboratory (China); Nankai University (China); The University of Texas Southwestern Medical Center (United States); Howard Hughes Medical Institute (United States); Capital Medical University (China)
Journal: Nature cell biology, volume 28, issue 5, pages 1031-1048
Dates: received 16 December 2024; accepted 10 February 2026; published online 30 April 2026; in print 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1038/s41556-026-01910-2 · PMID 42062482 · PMCID PMC13179133 · OpenAlex W7159586332
Open access: hybrid, a free copy (OpenAlex)
Status: data only
Categories: genetics / omics (modality), human (organism), mouse (organism), Alzheimer's / dementia (population), cellular / molecular (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, Machine learning, fMRI & imaging
Keywords: Metabolomics, Ageing, Mechanisms of disease
MeSH: Aging*, Alzheimer Disease*, Astrocytes*, Brain*, Metabolome*, Microglia*, Neurons*, Amyloid beta-Peptides, Animals, Disease Models, Animal, Glutathione, Humans, Male, Metabolomics, Mice, Mice, Inbred C57BL (* major topic)
Topic: Polyamine Metabolism and Applications (Molecular Biology, Biochemistry, Genetics and Molecular Biology), according to OpenAlex
Funding: National Natural Science Foundation of China (National Science Foundation of China) (82171367, 32170964); China Postdoctoral Science Foundation (2024M752878)
Citations: cited by 3 papers (Europe PMC); 117 references in the paper
Notices: A correction to this paper has been published (42680904, from Europe PMC)

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

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Data availability statement

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Read it in the paper: doi.org/10.1038/s41556-026-01910-2.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 18 authors, 3 keywords, 16 MeSH terms, 2 funders, 115 references, 1 integrity notice.

Cite

This paper

Yu, J., Li, F., Chen, X.-j., Mou, C., Yao, D., Bi, Z., Chen, X., Du, L., Feng, Z., Zhang, X., Yu, X., Zacharias, L. G., DeBerardinis, R. J., Zhang, L., Li, Z., Luo, B., Hu, X.-L., & Ge, W.-p. (2026). Characterizing the metabolomes of microglia, astrocytes and neurons in ageing and Alzheimer's brains. Nature cell biology, 28(5), 1031-1048. https://doi.org/10.1038/s41556-026-01910-2

BibTeX

@article{yu2026characterizing,
author = {Yu, Jie and Li, Fengzhi and Chen, Xing-jun and Mou, Chenye and Yao, Di and Bi, Zhanying and Chen, Xiaoli and Du, Lulu and Feng, Ziyan and Zhang, Xinshuang and Yu, Xiaoqian and Zacharias, Lauren G and DeBerardinis, Ralph J and Zhang, Li and Li, Zhen and Luo, Benyan and Hu, Xiao-Ling and Ge, Woo-ping},
title = {{Characterizing the metabolomes of microglia, astrocytes and neurons in ageing and Alzheimer's brains}},
journal = {Nature cell biology},
year = {2026},
month = apr,
volume = {28},
number = {5},
pages = {1031--1048},
publisher = {Nature Portfolio},
issn = {1465-7392},
doi = {10.1038/s41556-026-01910-2},
url = {https://doi.org/10.1038/s41556-026-01910-2},
pmid = {42062482},
pmcid = {PMC13179133}
}

RIS

TY - JOUR
AU - Yu, Jie
AU - Li, Fengzhi
AU - Chen, Xing-jun
AU - Mou, Chenye
AU - Yao, Di
AU - Bi, Zhanying
AU - Chen, Xiaoli
AU - Du, Lulu
AU - Feng, Ziyan
AU - Zhang, Xinshuang
AU - Yu, Xiaoqian
AU - Zacharias, Lauren G
AU - DeBerardinis, Ralph J
AU - Zhang, Li
AU - Li, Zhen
AU - Luo, Benyan
AU - Hu, Xiao-Ling
AU - Ge, Woo-ping
TI - Characterizing the metabolomes of microglia, astrocytes and neurons in ageing and Alzheimer's brains
T2 - Nature cell biology
J2 - Nat Cell Biol
PY - 2026
DA - 2026/04/30
VL - 28
IS - 5
SP - 1031
EP - 1048
SN - 1465-7392
PB - Nature Portfolio
DO - 10.1038/s41556-026-01910-2
UR - https://doi.org/10.1038/s41556-026-01910-2
LA - en
ER -

CSL-JSON

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