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Ventricular enlargement is associated with early Alzheimer's disease pathophysiology.

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  1. Welcome to the TNL's tutorial wiki!
  2. This repository includes tutorials and guides in the "Wiki" tab above.
  4. It also contains dictionary files for the following category of TRIAD data:
  5. 1. Neuropsych measures
  6. 2. Fluid biomarkers
  8. Current Wiki pages:
  10. Using Bash
  11. 1. BASH tutorial (Linux and MacOS command prompt)
  12. 2. MincTools 101
  13. 3. Image visualization and mask creation
  14. 4. ASHS segmentation
  15. 5. Distributing tasks to fully use computing power
  17. Software to work from your own computer
  18. 1. X2Go & MobaXTerm
  19. 2. Installing & setting up a MincTools virtual machine on Windows
  21. Statistics skills
  22. 1. Using GGPLOT (R)
  23. 2. Regressions and mediations (R)
  24. 3. RMINC (R)
  25. 4. VoxelStats (MATLAB)
  27. Other guides
  28. 1. Neuropsych battery description
  29. 2. Writing your (first) paper
  30. 3. PET imaging training video
  31. 4. Image quality control on Qrater

readme at commit 0dda6d6, no license · at the source

Overview

Authors: Seyyed Ali Hosseini1,2,3, Etienne Aumont1,2,3, Nesrine Rahmouni1,2,3, Marcel S Woo1,2,4,5, Arthur C Macedo1,2,3, Brandon Hall1,2,3, Lydia Trudel1,2,3, Tevy Chan1,2,3, Jaime Fernandez Arias1,2,3, Yi-Ting Wang1,2,3, Stijn Servaes1,2,3, Joseph Therriault1,2,3, Yansheng Zheng1,2,3, Kely Quispialaya Socualaya1,2,3, Gleb Bezgin1,2,3, Cécile Tissot6, Delphine Oliva-Lopez1,2,3, Robert Hopewell1,3, Chris Hung-Hsin Hsiao2, Catherine Saleh2
and 22 other authorsJenna Stevenson3, Firoza Lussier7, Liyong Wu1, Min Chu1, Sanjeev Chawla8, Vladimir Fonov2, Gassan Massarweh2, Yasser Iturria-Medina2, Jean-Paul Soucy2, David A Rudko2,9, Serge Gauthier2,3, Thomas Karikari7,10,11, Andréa Lessa Benedet10, Nicholas J Ashton10,12,13,14, Henrik Zetterberg10,15,16,17,18,19, Maxime Montembeault3, Paolo Vitali2, Kaj Blennow10,15,20,21, D Louis Collins2, Jesse Klostranec22, Tharick A Pascoal7, Pedro Rosa-Neto1,2,3,23
ORCID iDs: Marcel S Woo, Lydia Trudel, Jaime Fernandez Arias, Joseph Therriault, Cécile Tissot, Sanjeev Chawla, Vladimir Fonov, David A Rudko, Thomas Karikari, Paolo Vitali, D Louis Collins, Pedro Rosa-Neto
23 affiliations
  1. Translational Neuroimaging Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, Quebec H3A 2B4, Canada
  2. Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec H3A 1A1, Canada
  3. The McGill University Research Center for Studies in Aging, Douglas Mental Health Institute, Montreal, Quebec H4H 1R3, Canada
  4. Translational Neurodegeneration Laboratory, Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany
  5. Institute of Neuroimmunology and Multiple Sclerosis, University Medical Center Hamburg-Eppendorf, Hamburg 20246, Germany
  6. Department of Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
  7. Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
  8. Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA
  9. Department of Biomedical Engineering, McGill University, Montreal, Quebec H3A 2B4, Canada
  10. Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy, University of Gothenburg, Mölndal 413 45, Sweden
  11. Department of Neurology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15213, USA
  12. Wallenberg Centre for Molecular Medicine, University of Gothenburg, Gothenburg 413 45, Sweden
  13. King’s College London, Institute of Psychiatry, Department of Psychology and Neuroscience, Maurice Wohl Institute Clinical Neuroscience Institute, London SE5 9NU, UK
  14. NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation, London, UK
  15. Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal SE-431 80, Sweden
  16. Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK
  17. UK Dementia Research Institute at UCL, London, UK
  18. Hong Kong Center for Neurodegenerative Diseases, Division of Life Science, Hong Kong 999077, China
  19. Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53792, USA
  20. Paris Brain Institute, ICM, Pitié-Salpêtrière Hospital, Sorbonne University, Paris 75013, France
  21. Division of Life Sciences and Medicine, Department of Neurology, Neurodegenerative Disorder Research Center, Institute on Aging and Brain Disorders, University of Science and Technology of China and First Affiliated Hospital of USTC, Hefei 230001, P.R. China
  22. Department of Diagnostic and Interventional Neuroradiology, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec H3A 2B4, Canada
  23. The Peter O’Donnell Jr. Brain Institute (OBI), University of Texas Southwestern Medical Centre (UTSW), Dallas, TX 75390, USA
Institutions: Montreal Neurological Institute and Hospital (Canada); Douglas Mental Health University Institute (Canada); McGill University Research Centre for Studies in Aging (Canada); McGill University (Canada); University Medical Center Hamburg-Eppendorf (Germany); Institute of Neuroimmunology and Multiple Sclerosis (Germany); Lawrence Berkeley National Laboratory (United States); University of Pittsburgh (United States); University of Pennsylvania (United States); University of Gothenburg (Sweden); King's College London (United Kingdom); Wallenberg Centre for Molecular and Translational Medicine (Sweden); University of Wisconsin–Madison (United States); Sahlgrenska University Hospital (Sweden); UK Dementia Research Institute (United Kingdom); UCL Queen Square Institute of Neurology (United Kingdom); University College London (United Kingdom); University of Science and Technology of China (China); Sorbonne Université (France); Institut des Sciences Moléculaires (France); Pitié-Salpêtrière Hospital (France); Institut du Cerveau (France); The University of Texas Southwestern Medical Center (United States)
Journal: Brain communications, volume 8, issue 2, article fcag066
Dates: received 29 August 2025; accepted 6 March 2026; published online 7 March 2026
Type: Research article · Language: English
License: CC BY
Identifiers: DOI 10.1093/braincomms/fcag066 · PMID 41853044 · PMCID PMC12993450 · OpenAlex W7134168166
Open access: gold, a free copy (OpenAlex)
Status: empty repository
Categories: structural MRI / diffusion (modality), PET / SPECT (modality), Alzheimer's / dementia (population), cellular / molecular (subfield)
Methods: Statistics, Preprocessing, Connectivity, fMRI & imaging
Keywords: ventricular enlargement, CSF clearance, choroid plexus, protein aggregation, Alzheimer’s disease
Topic: Cerebrospinal fluid and hydrocephalus (Cellular and Molecular Neuroscience, Neuroscience), according to OpenAlex
Funding: Swedish Alzheimer Foundation (#AF-939721, #ALZ2022-0006, #FO2024-0048-TK-130, #AF-930351, #AF-968270, #ALFGBG-965240, #AF-994551, #ALFGBG-1006418); Canadian Institutes of Health Research (RFN 152985, 33397, 162303, CFI Project 34874, 159815, MOP-11-51-31, NIRG-12-92090, NIRP-12-259245); Swedish Research Council (#2017-00915, #2022-00732); European Union (SG-23-1038904 QC, JPND2019-466-236, ZEN-21-848495); NIA NIH HHS (R01 AG083874); Weston Brain Institute; Corona Foundation; Fonds de Recherche du Québec (2024-VICO-356138, 2020-VICO-279314); Kirsten and Freddy Johansen Foundation (MOP-11-51-31); La Fondation Recherche Alzheimer
Citations: not cited yet (Europe PMC); 67 references in the paper

Abstract

Alzheimer’s disease (AD) is characterized by progressive brain changes, including protein aggregation and structural changes. Cerebrospinal fluid (CSF) system abnormalities, such as ventricular dilation, increased choroid plexus volume or positron emission tomography (PET) ligand uptake in the CSF, have also been consistently described. We aimed to examine whether changes in CSF production and clearance might be associated with brain protein aggregation across biological stages of Alzheimer’s disease. We hypothesized an association between brain protein aggregation and changes on the CSF system. We examined 378 individuals from the Translational Biomarkers in Aging and Dementia (TRIAD) cohort with T1-weighted magnetic resonance imaging (MRI), amyloid-PET and tau-PET assessments. We assessed the lateral ventricle and choroid plexus volumes, both corrected for intracranial volume, in the MRI native space. Non-specific ventricular tracer standardized uptake value ratio (SUVR), derived from amyloid- and tau-PET images, was used as an indirect marker of choroid plexus-related clearance activity and served as a metric of CSF dynamics. Linear models tested associations amongst lateral ventricular volume (reflecting CSF space enlargement), choroid plexus volume (reflecting secretory tissue morphology) and ventricular SUVR (reflecting tracer activity within the CSF compartment and serving as an indirect marker of choroid plexus-related clearance function and CSF dynamics) with Aβ and tau aggregations. Analyses were restricted to within-modality associations, relating ventricular radioactivity to cortical pathology for each PET tracer. We found that when considered independently, larger ventricular and choroid plexus volumes were associated with higher neocortical Aβ-PET SUVR, particularly in the precuneus and cingulate cortices. Additionally, lower ventricular radioactivity (derived from amyloid-PET) showed strong negative associations in the dorsal apex of the neocortex. However, when all three ventricular parameters were included in the same model, these effects were mediated by ventricular volume. By contrast, the effect of the ventricular parameters on tau load was mediated by Aβ in the neocortex. Therefore, ventricular enlargement appears to be associated with Aβ load. Distinct from neurodegeneration, changes in ventricular parameters, particularly ventricular volume, are associated with upstream Alzheimer’s disease pathophysiology. While ventricular volume significantly mediated ventricular amyloid clearance, no such effect was observed for tau, suggesting distinct clearance mechanisms for these pathologies in Alzheimer’s disease.

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Commit: 0dda6d6309cbf9980b44aaccb376088c77e8cdca, 18 September 2025
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Software Heritage: not archived
Found in: “Data availability”
Holds: README
Not found: license file, CITATION.cff, environment file, tests, continuous integration, documentation
Availability: 1 check, the latest on 30 September 2026: the link answers
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At the source: github.com/TNL-MCSA/Tutorials/wiki

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Data availability

All requests for raw and analysed data and materials will be promptly reviewed by McGill university to verify if the request is subject to any intellectual property or confidentiality obligations. Anonymized data will be shared upon request to the study’s senior author from a qualified academic investigator for the sole purpose of replicating the procedures and results presented in this article. Any data and materials that can be shared will be released via a material transfer agreement. Data are not publicly available due to information that could compromise the privacy of research participants. Related documents, including study protocol and informed consent forms, can similarly be made available upon request. All scripts used for data preprocessing, statistical analyses and figure generation are openly available in our online code repository: https://github.com/TNL-MCSA/Tutorials/wiki.

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Version 1, 30 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 42 authors, 5 keywords, 10 funders, 65 references.

Cite

This paper

Hosseini, S. A., Aumont, E., Rahmouni, N., Woo, M. S., Macedo, A. C., Hall, B., Trudel, L., Chan, T., Fernandez Arias, J., Wang, Y.-T., Servaes, S., Therriault, J., Zheng, Y., Socualaya, K. Q., Bezgin, G., Tissot, C., Oliva-Lopez, D., Hopewell, R., Hsiao, C. H.-H., . . . Rosa-Neto, P. (2026). Ventricular enlargement is associated with early Alzheimer's disease pathophysiology. Brain communications, 8(2), fcag066. https://doi.org/10.1093/braincomms/fcag066

BibTeX

@article{hosseini2026ventricular,
author = {Hosseini, Seyyed Ali and Aumont, Etienne and Rahmouni, Nesrine and Woo, Marcel S and Macedo, Arthur C and Hall, Brandon and Trudel, Lydia and Chan, Tevy and Fernandez Arias, Jaime and Wang, Yi-Ting and Servaes, Stijn and Therriault, Joseph and Zheng, Yansheng and Socualaya, Kely Quispialaya and Bezgin, Gleb and Tissot, Cécile and Oliva-Lopez, Delphine and Hopewell, Robert and Hsiao, Chris Hung-Hsin and Saleh, Catherine and Stevenson, Jenna and Lussier, Firoza and Wu, Liyong and Chu, Min and Chawla, Sanjeev and Fonov, Vladimir and Massarweh, Gassan and Iturria-Medina, Yasser and Soucy, Jean-Paul and Rudko, David A and Gauthier, Serge and Karikari, Thomas and Benedet, Andréa Lessa and Ashton, Nicholas J and Zetterberg, Henrik and Montembeault, Maxime and Vitali, Paolo and Blennow, Kaj and Collins, D Louis and Klostranec, Jesse and Pascoal, Tharick A and Rosa-Neto, Pedro},
title = {{Ventricular enlargement is associated with early Alzheimer's disease pathophysiology}},
journal = {Brain communications},
year = {2026},
month = mar,
volume = {8},
number = {2},
pages = {fcag066},
publisher = {Oxford University Press},
issn = {2632-1297},
doi = {10.1093/braincomms/fcag066},
url = {https://doi.org/10.1093/braincomms/fcag066},
pmid = {41853044},
pmcid = {PMC12993450}
}

RIS

TY - JOUR
AU - Hosseini, Seyyed Ali
AU - Aumont, Etienne
AU - Rahmouni, Nesrine
AU - Woo, Marcel S
AU - Macedo, Arthur C
AU - Hall, Brandon
AU - Trudel, Lydia
AU - Chan, Tevy
AU - Fernandez Arias, Jaime
AU - Wang, Yi-Ting
AU - Servaes, Stijn
AU - Therriault, Joseph
AU - Zheng, Yansheng
AU - Socualaya, Kely Quispialaya
AU - Bezgin, Gleb
AU - Tissot, Cécile
AU - Oliva-Lopez, Delphine
AU - Hopewell, Robert
AU - Hsiao, Chris Hung-Hsin
AU - Saleh, Catherine
AU - Stevenson, Jenna
AU - Lussier, Firoza
AU - Wu, Liyong
AU - Chu, Min
AU - Chawla, Sanjeev
AU - Fonov, Vladimir
AU - Massarweh, Gassan
AU - Iturria-Medina, Yasser
AU - Soucy, Jean-Paul
AU - Rudko, David A
AU - Gauthier, Serge
AU - Karikari, Thomas
AU - Benedet, Andréa Lessa
AU - Ashton, Nicholas J
AU - Zetterberg, Henrik
AU - Montembeault, Maxime
AU - Vitali, Paolo
AU - Blennow, Kaj
AU - Collins, D Louis
AU - Klostranec, Jesse
AU - Pascoal, Tharick A
AU - Rosa-Neto, Pedro
TI - Ventricular enlargement is associated with early Alzheimer's disease pathophysiology
T2 - Brain communications
J2 - Brain Commun
PY - 2026
DA - 2026/03/07
VL - 8
IS - 2
SP - fcag066
SN - 2632-1297
PB - Oxford University Press
DO - 10.1093/braincomms/fcag066
UR - https://doi.org/10.1093/braincomms/fcag066
LA - en
ER -

CSL-JSON

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