SCD2 Alleviates Diabetes-Associated Cognitive Dysfunction by Improving Microglial Lipid Metabolism.
Overview
- Department of Endocrinology and Metabolism The Affiliated Hospital of Guizhou Medical University Guiyang Guizhou China
- Department of Neurology The Affiliated Hospital of Guizhou Medical University Guiyang Guizhou China
- Department of Endocrinology and Metabolism GuiQian International General Hospital Guiyang Guizhou China
Abstract
The mechanisms underlying diabetes‐associated cognitive dysfunction (DACD) are not fully understood, and microglial metabolic dysfunction is emerging as a key contributor. This study investigates whether stearoyl‐CoA desaturase 2 (SCD2) alleviates cognitive impairment by modulating microglial lipid metabolism and function. Bioinformatics analysis of a single‐cell RNA‐seq dataset (GSE201644) identified SCD2 downregulation in diabetic (db/
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data
Data links
- ncbi.nlm.nih.gov/
geo , NCBI; found in the text, “Bioinformatics Analysis”
Data Availability Statement
The data that support the findings of this study are available from the corresponding author upon reasonable request.
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 1, 30 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 6 authors, 6 keywords, 12 MeSH terms, 6 funders, 39 references.
Cite
This paper
Yang, Y., He, J., Zheng, J., Shao, B., Shi, L., & Zhang, M. (2026). SCD2 Alleviates Diabetes-Associated Cognitive Dysfunction by Improving Microglial Lipid Metabolism. Cell proliferation, 59(9), e70221. https://
BibTeX
@article{yang2026scd2,
author = {Yang, Yang and He, Juan and Zheng, Jing and Shao, Bing and Shi, Lixin and Zhang, Miao},
title = {{SCD2 Alleviates Diabetes-Associated Cognitive Dysfunction by Improving Microglial Lipid Metabolism}},
journal = {Cell proliferation},
year = {2026},
month = apr,
volume = {59},
number = {9},
pages = {e70221},
publisher = {Wiley},
issn = {0960-7722},
doi = {10.1111/
url = {https://
pmid = {42062093},
pmcid = {PMC13325817}
}
RIS
TY - JOUR
AU - Yang, Yang
AU - He, Juan
AU - Zheng, Jing
AU - Shao, Bing
AU - Shi, Lixin
AU - Zhang, Miao
TI - SCD2 Alleviates Diabetes-Associated Cognitive Dysfunction by Improving Microglial Lipid Metabolism
T2 - Cell proliferation
J2 - Cell Prolif
PY - 2026
DA - 2026/
VL - 59
IS - 9
SP - e70221
SN - 0960-7722
PB - Wiley
DO - 10.1111/
UR - https://
LA - en
ER -
CSL-JSON
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