Analysis of Task Demand Effects on Visual and Auditory Mismatch Negativity (MMN) Across Autistic and Schizotypal Traits.

Overview

Authors: Prune Mazer^1,2,3, Rita Pasion^2,4, Zohra Kamran Rao⁵, Celeste Silveira^3,6, Fernando Ferreira‐Santos²

ORCID iDs: Prune Mazer, Rita Pasion, Fernando Ferreira‐Santos

Institutions: Universidade do Porto (Portugal); Polytechnic Institute of Porto (Portugal); Universidade Lusófona do Porto (Portugal); Universidade Lusófona (Portugal); Tbilisi State University (Georgia); Hospital de São João (Portugal)

Journal: The European journal of neuroscience, volume 63, issue 7, article e70490

Dates: received 30 May 2025; accepted 19 March 2026; published online 10 April 2026; in print April 2026

Type: Research article · Language: English

License: CC BY

Identifiers: DOI 10.1111/ejn.70490 · PMID 41960881 · PMCID PMC13067925 · OpenAlex W7152983023

Open access: hybrid, a free copy (OpenAlex)

Status: data only

Categories: EEG (modality), human (organism), autism (population), cognitive (subfield)

Methods: Connectivity, Statistics, Preprocessing, Evoked potentials, fMRI & imaging

Keywords: autistic traits, EEG/ERP, mismatch negativity (MMN), predictive processing, schizotypy

MeSH: Auditory Perception*, Autistic Disorder*, Evoked Potentials*, Evoked Potentials, Auditory*, Schizotypal Personality Disorder*, Visual Perception*, Adolescent, Adult, Electroencephalography, Female, Humans, Male, Young Adult (* major topic)

Journal subjects: Special Issue Article, The Neuronal Basis of Mismatch Negativity (MMN) and Its Clinical Applications

Topic: Neuroscience and Music Perception (Cognitive Neuroscience, Neuroscience), according to OpenAlex

Funding: Fundação para a Ciência e a Tecnologia (10.54499/2021.07199.BD, 10.54499/2023.12283.PEX, 10.54499/UID/05380/2025, 10.54499/UID/PRR/05380/2025, 10.54499/UID/PRR2/05380/2025); COFAC ‐ Cooperativa de Formação e Animação Cultural, C.R.L (FAZER+/ILIND/HEI‐Lab/1/2024)

Citations: not cited yet (Europe PMC); 88 references in the paper

Abstract

Mismatch negativity (MMN) is an event‐related potential component elicited by violations of sensory predictions and is widely interpreted, within the predictive processing framework, as a neural correlate of prediction error. Disruptions in prediction error signalling have been proposed as a potential mechanism underlying the diverse cognitive and perceptual profiles observed in autism and schizophrenia spectrum conditions. In this study, 122 community participants completed auditory and visual oddball tasks with two levels of target detection difficulty while undergoing EEG recording, alongside self‐report measures of autistic and schizotypal traits. We found that increased task difficulty significantly reduced MMN amplitude in both modalities, with large effect sizes for auditory (d = 1.826) and visual (d = 1.005) MMN, indicating a modulation by perceptual load. Although associations between MMN amplitude and trait dimensions were limited, emerging patterns suggest a potential dissociation between social and nonsocial autistic traits. These findings address key gaps in the literature, particularly the underrepresentation of visual MMN, and highlight the importance of multidimensional, cross‐modal approaches to investigate prediction error mechanisms in neurodiverse populations.

Reproduced under the paper's license (CC BY), from the paper cited above.

Code

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Data

Datasets cited

osf:5sz7p — at OSF; found in “Data Availability Statement”
osf:7t2kd — at OSF; found in the text, “Methods”

Data Availability Statement

The data that support the findings of this study and the task paradigms employed are openly available in the Open Science Framework (OSF) at https://osf.io/5sz7p/ (DOI: 10.17605/OSF.IO/5SZ7P).

Reproduced under the paper's license (CC BY), from the paper cited above.

Versions

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Version 2, 28 September 2026

Publisher: — → Wiley

Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 5 authors, 5 keywords, 13 MeSH terms, 2 funders, 82 references.

Cite

This paper

Mazer, P., Pasion, R., Rao, Z. K., Silveira, C., & Ferreira‐Santos, F. (2026). Analysis of Task Demand Effects on Visual and Auditory Mismatch Negativity (MMN) Across Autistic and Schizotypal Traits. The European journal of neuroscience, 63(7), e70490. https://doi.org/10.1111/ejn.70490

BibTeX

@article{mazer2026analysis, author = {Mazer, Prune and Pasion, Rita and Rao, Zohra Kamran and Silveira, Celeste and Ferreira‐Santos, Fernando}, title = {{Analysis of Task Demand Effects on Visual and Auditory Mismatch Negativity (MMN) Across Autistic and Schizotypal Traits}}, journal = {The European journal of neuroscience}, year = {2026}, month = apr, volume = {63}, number = {7}, pages = {e70490}, publisher = {Wiley}, issn = {0953-816X}, doi = {10.1111/ejn.70490}, url = {https://doi.org/10.1111/ejn.70490}, pmid = {41960881}, pmcid = {PMC13067925} }

RIS

TY - JOUR AU - Mazer, Prune AU - Pasion, Rita AU - Rao, Zohra Kamran AU - Silveira, Celeste AU - Ferreira‐Santos, Fernando TI - Analysis of Task Demand Effects on Visual and Auditory Mismatch Negativity (MMN) Across Autistic and Schizotypal Traits T2 - The European journal of neuroscience J2 - Eur J Neurosci PY - 2026 DA - 2026/04/01 VL - 63 IS - 7 SP - e70490 SN - 0953-816X PB - Wiley DO - 10.1111/ejn.70490 UR - https://doi.org/10.1111/ejn.70490 LA - en ER -

CSL-JSON

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