Electroacupuncture enhances anti-tumor immunity in TNBC by reducing NE release and blocking α2-AR-mediated NGF/Hippo signaling.
Overview
- Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine,Shanghai, 200437 People’s Republic of China
- Integrated Traditional Chinese and Western Medicine Breast Department, Longhua Hospital Shanghai University of Traditional Chinese Medicine,Shanghai, 200030 People’s Republic of China
- Shanghai Institute of Acupuncture and Meridian Research, Shanghai, 200030 People’s Republic of China
- Institute of Surgery, Longhua Hospital Shanghai University of Traditional Chinese Medicine,Shanghai, 200030 People’s Republic of China
Abstract
Background: Targeting the neuro-immune microenvironment to suppress triple-negative breast cancer (TNBC) represents a critical strategy in tumor immunotherapy.
Methods: A syngeneic 4T1 orthotopic TNBC model in Balb/
Results: ST36 stimulation at 3 mA preferentially suppressed TNBC tumor growth and augmented intratumoral immune infiltration, characterized by elevated CD8+ T cells, NK cells, and M1-polarized macrophages. EA significantly enhanced CD8+ T cell effector capacity, upregulating perforin, granzyme B, CD69, and ZAP70 phosphorylation, and synergized with αPD-L1 in a CD8+ T cell-dependent manner. Mechanistically, EA activated c-Fos+/
Conclusion: EA at ST36 recalibrates neuro-sympathetic tone in TNBC by activating vagal cholinergic outflow, reducing NE-driven α2-AR/
Supplementary Information: The online version contains supplementary material available at 10.1186/
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data
Datasets cited
- figshare:32979993, at figshare; found in DataCite
- figshare:32979996, at figshare; found in DataCite
Data availability
No datasets were generated or analysed during the current study.
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
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Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 9 authors, 5 keywords, 3 funders, 65 references.
Cite
This paper
Li, F.-F., Huang, Y., Gao, C.-F., Wu, C.-Y., Sun, C.-P., Qin, Y.-N., Xie, Y., Liu, S., & Wu, H.-G. (2026). Electroacupuncture enhances anti-tumor immunity in TNBC by reducing NE release and blocking α2-AR-mediated NGF/
BibTeX
@article{li2026electroac
author = {Li, Fei-Fei and Huang, Yan and Gao, Chun-Fang and Wu, Chun-Yu and Sun, Chen-Ping and Qin, Yue-Nong and Xie, Ying and Liu, Sheng and Wu, Huan-Gan},
title = {{Electroacupuncture enhances anti-tumor immunity in TNBC by reducing NE release and blocking α2-AR-mediated NGF/
journal = {Chinese medicine},
year = {2026},
month = jul,
volume = {21},
number = {1},
pages = {186},
publisher = {BMC},
issn = {1749-8546},
doi = {10.1186/
url = {https://
pmid = {42443928},
pmcid = {PMC13361121}
}
RIS
TY - JOUR
AU - Li, Fei-Fei
AU - Huang, Yan
AU - Gao, Chun-Fang
AU - Wu, Chun-Yu
AU - Sun, Chen-Ping
AU - Qin, Yue-Nong
AU - Xie, Ying
AU - Liu, Sheng
AU - Wu, Huan-Gan
TI - Electroacupuncture enhances anti-tumor immunity in TNBC by reducing NE release and blocking α2-AR-mediated NGF/
T2 - Chinese medicine
J2 - Chin Med
PY - 2026
DA - 2026/
VL - 21
IS - 1
SP - 186
SN - 1749-8546
PB - BMC
DO - 10.1186/
UR - https://
LA - en
ER -
CSL-JSON
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