The Distinct Electrophysiological Mechanisms in the Cortico-Striatal Circuit of LID Rats.
Overview
- Key Laboratory of Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China; (T.H.); (H.W.); (H.N.); (Y.S.); (F.Z.)
- Zhejiang Key Laboratory of Intelligent Sensing Technology and Advanced Medical Instrument, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China
- Binjiang Institute of Zhejiang University, Hangzhou 311000, China
- Department of Neurosurgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 311100, China
- The State Key Laboratory of Brain-Machine Intelligence, Zhejiang University, Hangzhou 311100, China
Abstract
Levodopa-induced dyskinesia (LID) is a severe motor complication associated with long-term levodopa (L-DOPA) treatment for Parkinson’s disease (PD). Its underlying mechanisms remain unclear, and candidate biomarkers lack consistency. To investigate cortico-striatal network alterations associated with LID, we simultaneously recorded single-neuron spikes and local field potentials (LFPs) from the dorsolateral striatum (DLS) and the primary motor cortex (M1) in LID rats. Our results showed that in the DLS, the LID group had a greater number of putative fast-spiking interneurons (FSIs) with lower firing rates, and fewer putative medium spiny neurons (MSNs) with higher firing rates. In M1, pyramidal neurons were fewer but fired faster, while interneurons were more numerous with no change in firing rate. Although gamma power increased and delta power decreased in both regions in LID rats, delta-gamma phase-amplitude coupling (PAC) was present in the DLS but absent in M1. Furthermore, cross-regional PAC analysis revealed significantly stronger coupling between the low-frequency phase of M1 and the high-frequency amplitude of the DLS than in the opposite direction, indicating an asymmetric pattern of cortico-striatal coupling in LID. These findings demonstrate region-specific alterations in neuronal activity and oscillatory coupling associated with LID and suggest that asymmetric cortico-striatal PAC may serve as a promising electrophysiological marker for characterizing abnormal network dynamics underlying dyskinesia.
Reproduced under the paper's license (CC BY), from the paper cited above.
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Data Availability Statement
The data supporting the findings of this study are available from the corresponding author upon reasonable request, and the source code used for data analysis is also available from the corresponding author upon reasonable request. Access to the data and code may be subject to institutional regulations, ethical approvals, and reasonable restrictions related to ongoing research.
Reproduced under the paper's license (CC BY), from the paper cited above.
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Version 1, 27 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 8 authors, 8 keywords, 3 funders, 51 references.
Cite
This paper
He, T., Wang, H., Ni, H., Sun, Y., Gao, X., Zhou, F., Zhang, J., & Xu, K. (2026). The Distinct Electrophysiological Mechanisms in the Cortico-Striatal Circuit of LID Rats. Biology, 15(13), 1074. https://
BibTeX
@article{he2026distinct,
author = {He, Tingting and Wang, Hongyu and Ni, Haoqi and Sun, Yuting and Gao, Xiang and Zhou, Fan and Zhang, Jianmin and Xu, Kedi},
title = {{The Distinct Electrophysiological Mechanisms in the Cortico-Striatal Circuit of LID Rats}},
journal = {Biology},
year = {2026},
month = jul,
volume = {15},
number = {13},
pages = {1074},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
issn = {2079-7737},
doi = {10.3390/
url = {https://
pmid = {42450621},
pmcid = {PMC13359917}
}
RIS
TY - JOUR
AU - He, Tingting
AU - Wang, Hongyu
AU - Ni, Haoqi
AU - Sun, Yuting
AU - Gao, Xiang
AU - Zhou, Fan
AU - Zhang, Jianmin
AU - Xu, Kedi
TI - The Distinct Electrophysiological Mechanisms in the Cortico-Striatal Circuit of LID Rats
T2 - Biology
J2 - Biology (Basel)
PY - 2026
DA - 2026/
VL - 15
IS - 13
SP - 1074
SN - 2079-7737
PB - Multidisciplinary Digital Publishing Institute (MDPI)
DO - 10.3390/
UR - https://
LA - en
ER -
CSL-JSON
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