Central Administration of Recombinant IGF1 Is Neuroprotective in a Rodent Model of Acute Liver Failure.
Overview
- Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA; (Y.W.); (K.R.); (E.W.); (J.V.); (J.T.); (E.G.); (M.P.); (P.M.)
- Department of Innovation, Education and Technology, Baylor College of Medicine, Temple, TX 76508, USA
- Department of Neurosurgery, Dell Medical School, The University of Texas at Austin, Austin, TX 78712, USA
- Department of Internal Medicine, Dell Medical School, The University of Texas at Austin, Austin, TX 78712, USA
Abstract
Acute liver failure is often accompanied by neurological disturbances collectively referred to as hepatic encephalopathy (HE), characterized by neuroinflammation and subsequent cognitive decline. Insulin-like growth factor 1 (IGF1) is a neuroprotective peptide with anti-inflammatory properties in the brain. The role of IGF1 in cognitive deficits and neuroinflammation during HE remains largely unexplored. In C57Bl/
Reproduced under the paper's license (CC BY), from the paper cited above.
Code
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Data
Datasets cited
- figshare:31892272 — at figshare; found in “Data Availability Statement”
Data Availability Statement
The raw data supporting this study have been deposited in Figshare and are publicly available at https://
Reproduced under the paper's license (CC BY), from the paper cited above.
Versions
The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.
Version 1, 29 September 2026: the first record
Recorded: type, language, journal, volume, issue, pages, dates, 11 authors, 6 keywords, 14 MeSH terms, 1 funder, 50 references.
Cite
This paper
Wang, Y., McMillin, M., Frampton, G., Rhodes, K., Williams, E., Venter, J., Tyson, J., Gupta, E., Patankar, M., Mireles, P., & DeMorrow, S. (2026). Central Administration of Recombinant IGF1 Is Neuroprotective in a Rodent Model of Acute Liver Failure. International journal of molecular sciences, 27(8), 3547. https://
BibTeX
@article{wang2026central
author = {Wang, Yubo and McMillin, Matthew and Frampton, Gabriel and Rhodes, Kathryn and Williams, Elaina and Venter, Juliet and Tyson, Jace and Gupta, Esha and Patankar, Mihika and Mireles, Patrick and DeMorrow, Sharon},
title = {{Central Administration of Recombinant IGF1 Is Neuroprotective in a Rodent Model of Acute Liver Failure}},
journal = {International journal of molecular sciences},
year = {2026},
month = apr,
volume = {27},
number = {8},
pages = {3547},
publisher = {Multidisciplinary Digital Publishing Institute (MDPI)},
issn = {1422-0067},
doi = {10.3390/
url = {https://
pmid = {42074188},
pmcid = {PMC13116921}
}
RIS
TY - JOUR
AU - Wang, Yubo
AU - McMillin, Matthew
AU - Frampton, Gabriel
AU - Rhodes, Kathryn
AU - Williams, Elaina
AU - Venter, Juliet
AU - Tyson, Jace
AU - Gupta, Esha
AU - Patankar, Mihika
AU - Mireles, Patrick
AU - DeMorrow, Sharon
TI - Central Administration of Recombinant IGF1 Is Neuroprotective in a Rodent Model of Acute Liver Failure
T2 - International journal of molecular sciences
J2 - Int J Mol Sci
PY - 2026
DA - 2026/
VL - 27
IS - 8
SP - 3547
SN - 1422-0067
PB - Multidisciplinary Digital Publishing Institute (MDPI)
DO - 10.3390/
UR - https://
LA - en
ER -
CSL-JSON
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"container-title": "International journal of molecular sciences",
"author": [
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"DOI": "10.3390/
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"ISSN": "1422-0067",
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"URL": "https://
"language": "en",
"issued": {
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