OSCR

Endothelial NOX4‑driven oxidative stress inhibition reverses HtrA1 deficiency‑induced blood‑brain barrier disruption and cognitive impairment.

Overview

Authors: Shi-Na Song1,2, Jun-Ying Wu2, Mao-Mei Song1, Xiao-Feng Li1, Jian-Ming Wang3, Wen-Hui Jia4, Chang-Xin Li1, Sui-Yi Xu1,5
ORCID iDs: Sui-Yi Xu
  1. Department of Neurology, Headache Center, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China
  2. Department of Rehabilitation, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China
  3. Department of Wound Repair, General Hospital of Taiyuan Iron and Steel Group Co., Ltd., Taiyuan, Shanxi 030003, P.R. China
  4. Department of Neurology, Shanxi Provincial People's Hospital, Taiyuan, Shanxi 030012, P.R. China
  5. Department of Neurology, Headache Center, Shenzhen Baoan People's Hospital, The Second Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong 518000, P.R. China
Institutions: Shanxi Medical University (China); First Hospital of Shanxi Medical University (China); Taiyuan Iron and Steel Group (China) (China); Shanxi Provincial People’s Hospital (China)
Journal: International journal of molecular medicine, volume 58, issue 1, article 194
Dates: received 8 December 2025; accepted 26 March 2026; published online 19 May 2026; in print July 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.3892/ijmm.2026.5865 · PMID 42169653 · PMCID PMC13215333 · OpenAlex W7161628005
Open access: hybrid, a free copy (OpenAlex)
Status: data only
Categories: genetics / omics (modality), human (organism), mouse (organism), stroke (population), cellular / molecular (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions, Evoked potentials
Keywords: heterozygous HTRA1 mutation, CSVD, oxidative stress, apoptosis, blood-brain barrier
MeSH: Blood-Brain Barrier*, Cognitive Dysfunction*, Endothelial Cells*, High-Temperature Requirement A Serine Peptidase 1*, NADPH Oxidase 4*, Oxidative Stress*, Adult, Animals, Apoptosis, Female, Humans, Male, Mice, Middle Aged, Mutation (* major topic)
Topic: Cerebrovascular and genetic disorders (Neurology, Medicine), according to OpenAlex
Citations: not cited yet (Europe PMC); 71 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.3892/ijmm.2026.5865.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 28 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 8 authors, 5 keywords, 15 MeSH terms, 71 references.

Cite

This paper

Song, S.-N., Wu, J.-Y., Song, M.-M., Li, X.-F., Wang, J.-M., Jia, W.-H., Li, C.-X., & Xu, S.-Y. (2026). Endothelial NOX4‑driven oxidative stress inhibition reverses HtrA1 deficiency‑induced blood‑brain barrier disruption and cognitive impairment. International journal of molecular medicine, 58(1), 194. https://doi.org/10.3892/ijmm.2026.5865

BibTeX

@article{song2026endothelial,
author = {Song, Shi-Na and Wu, Jun-Ying and Song, Mao-Mei and Li, Xiao-Feng and Wang, Jian-Ming and Jia, Wen-Hui and Li, Chang-Xin and Xu, Sui-Yi},
title = {{Endothelial NOX4‑driven oxidative stress inhibition reverses HtrA1 deficiency‑induced blood‑brain barrier disruption and cognitive impairment}},
journal = {International journal of molecular medicine},
year = {2026},
month = may,
volume = {58},
number = {1},
pages = {194},
publisher = {Spandidos Publications},
issn = {1107-3756},
doi = {10.3892/ijmm.2026.5865},
url = {https://doi.org/10.3892/ijmm.2026.5865},
pmid = {42169653},
pmcid = {PMC13215333}
}

RIS

TY - JOUR
AU - Song, Shi-Na
AU - Wu, Jun-Ying
AU - Song, Mao-Mei
AU - Li, Xiao-Feng
AU - Wang, Jian-Ming
AU - Jia, Wen-Hui
AU - Li, Chang-Xin
AU - Xu, Sui-Yi
TI - Endothelial NOX4‑driven oxidative stress inhibition reverses HtrA1 deficiency‑induced blood‑brain barrier disruption and cognitive impairment
T2 - International journal of molecular medicine
J2 - Int J Mol Med
PY - 2026
DA - 2026/05/22
VL - 58
IS - 1
SP - 194
SN - 1107-3756
PB - Spandidos Publications
DO - 10.3892/ijmm.2026.5865
UR - https://doi.org/10.3892/ijmm.2026.5865
LA - en
ER -

CSL-JSON

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"container-title": "International journal of molecular medicine",
"author": [
{
"family": "Song",
"given": "Shi-Na"
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{
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{
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{
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},
{
"family": "Wang",
"given": "Jian-Ming"
},
{
"family": "Jia",
"given": "Wen-Hui"
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{
"family": "Li",
"given": "Chang-Xin"
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{
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"given": "Sui-Yi"
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],
"container-title-short": "Int J Mol Med",
"volume": "58",
"issue": "1",
"page": "194",
"DOI": "10.3892/ijmm.2026.5865",
"PMID": "42169653",
"PMCID": "PMC13215333",
"ISSN": "1107-3756",
"publisher": "Spandidos Publications",
"URL": "https://doi.org/10.3892/ijmm.2026.5865",
"language": "en",
"issued": {
"date-parts": [
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]
}
}

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