OSCR

Infiltrating monocyte-derived macrophages does not survive long term in stroke brain despite their dominance in the acute ischemic core and myeloid derived IGF-1 play dichotomous roles in stroke recovery.

Overview

Authors: Hongli Ma1, Nicolas Hugues1, Kirsten Voice1, Joshua Peter1, Aleksandr Taranov1, Christina Thapa2, Krishna Roskin3,4, Yu Luo1,4
ORCID iDs: Hongli Ma, Aleksandr Taranov, Yu Luo
  1. Department of Molecular and Cellular Biosciences, University of Cincinnati,Cincinnati, OH 45229 USA
  2. Center for Psychiatric Genetics, NorthShore University HealthSystem,Evanston, IL 60201 USA
  3. Divisions of Biomedical Informatics, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine,Cincinnati, OH 45229 USA
  4. Division of Immunobiology, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine,Cincinnati, OH 45229 USA
Institutions: University of Cincinnati (United States); Endeavor Health (United States)
Journal: Genome medicine, volume 18, issue 1, article 122
Dates: received 23 January 2026; accepted 2 June 2026; published online 10 June 2026
Type: Research article · Language: English
License: CC BY-NC-ND
Identifiers: DOI 10.1186/s13073-026-01687-x · PMID 42271455 · PMCID PMC13474826 · OpenAlex W7164120728
Open access: gold, a free copy (OpenAlex)
Status: data only
Categories: genetics / omics (modality), mouse (organism), stroke (population), cellular / molecular (subfield)
Methods: Statistics, Smoothing, state filtering, decompositions
Keywords: Microglia, Infiltration of monocytes-derived macrophages (iMM), Ischemic stroke, Igf1, Single-cell RNA sequencing
MeSH: Brain*, Brain Ischemia*, Insulin-Like Growth Factor I*, Macrophages*, Monocytes*, Stroke*, Animals, Disease Models, Animal, Male, Mice, Microglia, Transcriptome (* major topic)
Topic: Neuroinflammation and Neurodegeneration Mechanisms (Neurology, Neuroscience), according to OpenAlex
Funding: NIH grants (R01NS125074)
Citations: cited by 2 papers (Europe PMC); 89 references in the paper

Abstract

The abstract is not reproduced here: the paper's license (CC BY-NC-ND) does not allow it. Read it in the paper, at the publisher or on Europe PMC.

Code

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Data

Datasets cited

Data availability statement

The paper has a data availability statement. Its license (CC BY-NC-ND) does not allow reproducing it here; in short, from what the harvester recognized in it:

Read it in the paper: doi.org/10.1186/s13073-026-01687-x.

Versions

The history of this record: each version stored by the harvester or made by a correction of its authors or of the maintainers of its code, and what changed in its facts. The texts of the paper (its abstract, its availability statements) are not part of it; versions that changed only those are not listed.

Version 1, 27 September 2026: the first record

Recorded: type, language, journal, volume, issue, pages, dates, 8 authors, 5 keywords, 12 MeSH terms, 1 funder, 88 references.

Cite

This paper

Ma, H., Hugues, N., Voice, K., Peter, J., Taranov, A., Thapa, C., Roskin, K., & Luo, Y. (2026). Infiltrating monocyte-derived macrophages does not survive long term in stroke brain despite their dominance in the acute ischemic core and myeloid derived IGF-1 play dichotomous roles in stroke recovery. Genome medicine, 18(1), 122. https://doi.org/10.1186/s13073-026-01687-x

BibTeX

@article{ma2026infiltrating,
author = {Ma, Hongli and Hugues, Nicolas and Voice, Kirsten and Peter, Joshua and Taranov, Aleksandr and Thapa, Christina and Roskin, Krishna and Luo, Yu},
title = {{Infiltrating monocyte-derived macrophages does not survive long term in stroke brain despite their dominance in the acute ischemic core and myeloid derived IGF-1 play dichotomous roles in stroke recovery}},
journal = {Genome medicine},
year = {2026},
month = jun,
volume = {18},
number = {1},
pages = {122},
publisher = {BMC},
issn = {1756-994X},
doi = {10.1186/s13073-026-01687-x},
url = {https://doi.org/10.1186/s13073-026-01687-x},
pmid = {42271455},
pmcid = {PMC13474826}
}

RIS

TY - JOUR
AU - Ma, Hongli
AU - Hugues, Nicolas
AU - Voice, Kirsten
AU - Peter, Joshua
AU - Taranov, Aleksandr
AU - Thapa, Christina
AU - Roskin, Krishna
AU - Luo, Yu
TI - Infiltrating monocyte-derived macrophages does not survive long term in stroke brain despite their dominance in the acute ischemic core and myeloid derived IGF-1 play dichotomous roles in stroke recovery
T2 - Genome medicine
J2 - Genome Med
PY - 2026
DA - 2026/06/10
VL - 18
IS - 1
SP - 122
SN - 1756-994X
PB - BMC
DO - 10.1186/s13073-026-01687-x
UR - https://doi.org/10.1186/s13073-026-01687-x
LA - en
ER -

CSL-JSON

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"container-title": "Genome medicine",
"author": [
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"family": "Ma",
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"ISSN": "1756-994X",
"publisher": "BMC",
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"language": "en",
"issued": {
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}

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